CA2986687A1 - Manufacturing multi-dose injection ready dendritic cell vaccines - Google Patents
Manufacturing multi-dose injection ready dendritic cell vaccinesInfo
- Publication number
- CA2986687A1 CA2986687A1 CA2986687A CA2986687A CA2986687A1 CA 2986687 A1 CA2986687 A1 CA 2986687A1 CA 2986687 A CA2986687 A CA 2986687A CA 2986687 A CA2986687 A CA 2986687A CA 2986687 A1 CA2986687 A1 CA 2986687A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- cancer
- antigen
- dendritic cell
- vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- A61K39/4615—Dendritic cells
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464403—Receptors for growth factors
- A61K39/464406—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- A—HUMAN NECESSITIES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- Chemical Kinetics & Catalysis (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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US201562165445P | 2015-05-22 | 2015-05-22 | |
US62/165,445 | 2015-05-22 | ||
PCT/US2015/041022 WO2016011422A2 (en) | 2014-07-17 | 2015-07-17 | Manufacturing of multi-dose injection ready dendritic cell vaccines and combination therapy for blocking her2 and her3 |
WOPCT/US2015/041022 | 2015-07-17 | ||
PCT/US2016/021090 WO2016190940A1 (en) | 2015-05-22 | 2016-03-05 | Manufacturing multi-dose injection ready dendritic cell vaccines |
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CA2986687A1 true CA2986687A1 (en) | 2016-12-01 |
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CA2986687A Abandoned CA2986687A1 (en) | 2015-05-22 | 2016-03-05 | Manufacturing multi-dose injection ready dendritic cell vaccines |
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EP (1) | EP3302539A4 (zh) |
JP (2) | JP2018515421A (zh) |
CN (1) | CN107206061A (zh) |
CA (1) | CA2986687A1 (zh) |
WO (1) | WO2016190940A1 (zh) |
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WO2016011347A1 (en) * | 2014-07-17 | 2016-01-21 | The Trustees Of The University Of Pennsylvania | Multi-dose injection ready dendritic cell vaccines and combination therapy for cancer |
JPWO2019103151A1 (ja) * | 2017-11-27 | 2021-01-21 | 国立大学法人千葉大学 | 核酸を細胞内に送達するための脂質膜構造体 |
CA3142777A1 (en) * | 2019-06-21 | 2020-12-24 | Vaccinex, Inc. | Combination therapy with semaphorin-4d blockade (sema4d) and dc1 therapy |
CN118141747B (zh) * | 2024-03-07 | 2024-09-27 | 广东医科大学 | 一种治疗黑色素瘤的凝胶型微针贴片 |
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US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
US5801005A (en) * | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
DE10041515A1 (de) * | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
WO2003012085A1 (en) * | 2001-07-30 | 2003-02-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Antigen presenting cells, method for their preparation and their use for cancer vaccines |
CA2504451A1 (en) * | 2004-08-10 | 2006-02-10 | Geron Corporation | Dendritic cell vaccines for treating cancer made from embryonic stem cells |
US8247227B2 (en) * | 2006-08-28 | 2012-08-21 | The Cleveland Clinic Foundation | Dendritic cell precursors |
CN102933228A (zh) * | 2010-03-15 | 2013-02-13 | 宾夕法尼亚大学董事会 | 制备和储存活化的、成熟树突细胞的体系和方法 |
KR20220038548A (ko) * | 2010-12-30 | 2022-03-28 | 셀룰래리티 인코포레이티드 | 세포의 동결보존 및 캡슐화 방법 |
EP2548571A1 (en) * | 2011-07-22 | 2013-01-23 | Institut Curie | Compositions having means for targeting at least one antigen to dendritic cells |
CN107073038A (zh) * | 2014-03-14 | 2017-08-18 | 宾夕法尼亚大学理事会 | 在癌症和免疫恢复中监测cd4+1型t辅助细胞应答的方法 |
WO2016011347A1 (en) * | 2014-07-17 | 2016-01-21 | The Trustees Of The University Of Pennsylvania | Multi-dose injection ready dendritic cell vaccines and combination therapy for cancer |
CA2979676A1 (en) * | 2015-03-13 | 2016-09-29 | Brian J. Czerniecki | Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration |
US20180171294A1 (en) * | 2015-03-26 | 2018-06-21 | The Trustees Of The University Of Pennsylvania | In vitro artificial lymph node method for sensitization and expansion of t cells for therapy and epitope mapping |
EP3273975A4 (en) * | 2015-03-26 | 2018-10-17 | The Trustees Of The University Of Pennsylvania | In vitro artificial lymph node for sensitization and expansion of t cells for therapy and epitope mapping |
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EP3302539A4 (en) | 2018-12-19 |
WO2016190940A1 (en) | 2016-12-01 |
EP3302539A1 (en) | 2018-04-11 |
JP2020180139A (ja) | 2020-11-05 |
CN107206061A (zh) | 2017-09-26 |
JP2018515421A (ja) | 2018-06-14 |
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