CA2981614C - A composition comprising a photosensitive compound in a polymeric nanoparticle, and a method of using the composition - Google Patents

A composition comprising a photosensitive compound in a polymeric nanoparticle, and a method of using the composition Download PDF

Info

Publication number
CA2981614C
CA2981614C CA2981614A CA2981614A CA2981614C CA 2981614 C CA2981614 C CA 2981614C CA 2981614 A CA2981614 A CA 2981614A CA 2981614 A CA2981614 A CA 2981614A CA 2981614 C CA2981614 C CA 2981614C
Authority
CA
Canada
Prior art keywords
composition
polymer
sinc
photosensitive compound
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2981614A
Other languages
English (en)
French (fr)
Other versions
CA2981614A1 (en
Inventor
Olena TARATULA
Oleh Taratula
Adam ALANI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon State University
Original Assignee
Oregon State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon State University filed Critical Oregon State University
Publication of CA2981614A1 publication Critical patent/CA2981614A1/en
Application granted granted Critical
Publication of CA2981614C publication Critical patent/CA2981614C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nanotechnology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2981614A 2015-04-20 2016-04-18 A composition comprising a photosensitive compound in a polymeric nanoparticle, and a method of using the composition Active CA2981614C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562150125P 2015-04-20 2015-04-20
US62/150,125 2015-04-20
PCT/US2016/028113 WO2016172046A1 (en) 2015-04-20 2016-04-18 A composition comprising a photosensitive compound in a polymeric nanoparticle, and a method of using the composition

Publications (2)

Publication Number Publication Date
CA2981614A1 CA2981614A1 (en) 2016-10-27
CA2981614C true CA2981614C (en) 2023-09-05

Family

ID=57144184

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2981614A Active CA2981614C (en) 2015-04-20 2016-04-18 A composition comprising a photosensitive compound in a polymeric nanoparticle, and a method of using the composition

Country Status (6)

Country Link
US (1) US10646472B2 (enExample)
EP (1) EP3285765B1 (enExample)
JP (1) JP6769992B2 (enExample)
CN (1) CN107613975B (enExample)
CA (1) CA2981614C (enExample)
WO (2) WO2016172046A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3285765B1 (en) * 2015-04-20 2020-04-08 Oregon State University A composition comprising a photosensitive compound in a polymeric nanoparticle, and a method of using the composition
CN107789623B (zh) * 2017-11-09 2020-12-15 福州大学 哌嗪取代硅酞菁及其在光热治疗中的应用
RU2020132481A (ru) * 2018-03-30 2022-05-04 Торэй Индастриз, Инк. Биоразлагаемый блок-сополимер
US20210268129A1 (en) * 2018-06-22 2021-09-02 The Governers Of The University Of Alberta Theranostic Radiophotodynamic Therapy Nanoparticles
JP7371476B2 (ja) * 2018-12-13 2023-10-31 東洋インキＳｃホールディングス株式会社 近赤外蛍光組成物および近赤外蛍光標識剤
WO2020132980A1 (zh) * 2018-12-26 2020-07-02 深圳先进技术研究院 细菌-光热纳米颗粒复合物及制备方法和应用
US20220211860A1 (en) * 2019-05-02 2022-07-07 The University Of Sydney Peptide derivatives and conjugates thereof for treating cancer
AU2021299343A1 (en) * 2020-06-30 2023-03-02 Kenvue Brands Llc Device and method for controlling treatment for a skin condition using a tracer
KR20230047155A (ko) 2020-08-03 2023-04-06 존슨 앤드 존슨 컨수머 인코포레이티드 눈밑 브라이트닝을 부여하기 위한 화장 조성물의 선택적 도포용 시스템 및 방법
CN112972690B (zh) * 2021-02-22 2022-12-23 上海交通大学医学院附属第九人民医院 一种基于三角纳米金载体、制备方法及用途
EP4066818B1 (en) * 2021-04-01 2023-11-29 Agfa-Gevaert Nv Near infrared absorbing composite resin particles
CN113368235B (zh) * 2021-05-11 2022-11-15 上海师范大学 一种Gd-NGQDs/BTS@PLGA-PEG纳米材料及其制备方法和应用
US20240424147A1 (en) * 2021-10-05 2024-12-26 The Trustees Of The University Of Pennsylvania Phthalocyanine-loaded micelles for the direct visualization of tumors
CN116637209B (zh) * 2023-05-18 2024-06-07 南京溯远基因科技有限公司 一种荧光染料复合物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635740B1 (en) 1997-03-27 2003-10-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Ligand/lytic peptide compositions and methods of use
JP2010083860A (ja) * 2008-02-29 2010-04-15 Kyoto Univ ポリマーナノ微粒子及び光分子イメージング用造影剤
IT1391530B1 (it) * 2008-07-31 2012-01-11 Cyanagen S R L Particelle attive per applicazioni bio-analitiche e metodi per la loro preparazione
US9517277B2 (en) 2011-07-15 2016-12-13 University Of Georgia Research Foundation, Inc. Immune-stimulating photoactive hybrid nanoparticles
US8974830B2 (en) * 2012-02-23 2015-03-10 Canon Kabushiki Kaisha Particles and contrast agent including the same for optical imaging
US20130336889A1 (en) * 2012-06-14 2013-12-19 National Taiwan University Nanoparticle and method for detecting or treating a tumor using the same
WO2015026963A2 (en) * 2013-08-21 2015-02-26 Oregon State University Phthalocy anine-dendrimer compositions and a method of using
EP3285765B1 (en) * 2015-04-20 2020-04-08 Oregon State University A composition comprising a photosensitive compound in a polymeric nanoparticle, and a method of using the composition
ES2992591T3 (en) 2015-08-18 2024-12-16 Rakuten Medical Inc Compositions, combinations and related methods for photoimmunotherapy

Also Published As

Publication number Publication date
EP3285765A4 (en) 2018-12-05
WO2016172046A1 (en) 2016-10-27
WO2019079201A2 (en) 2019-04-25
WO2019079201A3 (en) 2019-05-31
EP3285765A1 (en) 2018-02-28
EP3285765B1 (en) 2020-04-08
US10646472B2 (en) 2020-05-12
CA2981614A1 (en) 2016-10-27
CN107613975A (zh) 2018-01-19
JP2018513875A (ja) 2018-05-31
US20180028496A1 (en) 2018-02-01
CN107613975B (zh) 2021-08-03
JP6769992B2 (ja) 2020-10-14

Similar Documents

Publication Publication Date Title
EP3285765B1 (en) A composition comprising a photosensitive compound in a polymeric nanoparticle, and a method of using the composition
US20220347314A1 (en) Microbubble-chemotherapeutic agent complex for sonodynamic therapy
Xue et al. Porphyrin-based nanomedicines for cancer treatment
Rahman et al. Photodynamic therapy for bladder cancers, a focused review
Li et al. Combination of active targeting, enzyme-triggered release and fluorescent dye into gold nanoclusters for endomicroscopy-guided photothermal/photodynamic therapy to pancreatic ductal adenocarcinoma
JP5979385B2 (ja) リポソーム複合体
Hu et al. Post-synthesis strategy to integrate porphyrinic metal–organic frameworks with CuS NPs for synergistic enhanced photo-therapy
WO2015026963A2 (en) Phthalocy anine-dendrimer compositions and a method of using
EP3508221A1 (en) Tumor-targeting photosensitizer-drug conjugate, method for preparing same and pharmaceutical composition for preventing or treating tumor containing same
Yang et al. A Nd3+ sensitized upconversion nanosystem with dual photosensitizers for improving photodynamic therapy efficacy
Wu et al. Pea protein/gold nanocluster/indocyanine green ternary hybrid for near-infrared fluorescence/computed tomography dual-modal imaging and synergistic photodynamic/photothermal therapy
Sun et al. Highly efficient water-soluble photosensitizer based on chlorin: synthesis, characterization, and evaluation for photodynamic therapy
Wang et al. Dual-mode imaging guided multifunctional theranosomes with mitochondria targeting for photothermally controlled and enhanced photodynamic therapy in vitro and in vivo
AU2009347929A1 (en) Targeted nano-photomedicines for photodynamic therapy of cancer
Bao et al. Design and construction of IR780-and EGCG-based and mitochondrial targeting nanoparticles and their application in tumor chemo-phototherapy
Guo et al. Self-assembled Camptothecin derivatives–Curcuminoids conjugate for combinatorial chemo-photodynamic therapy to enhance anti-tumor efficacy
Vincy et al. Optical characteristics of indocyanine green J-aggregates induced by cisplatin for phototheranostic applications
Korneev et al. Nanoparticles-based photosensitizers with effect of aggregation-induced emission
Luo et al. Translational albumin nanocarrier caging photosensitizer for efficient cancer photodynamic therapy
Wang et al. Dual pH-responsive polypeptide nanoprobes for lysosomes enhanced bioimaging and tumor photothermal therapy under 1064 nm irradiation
Istomin et al. Uptake and phototoxicity of tricarbocyanine indolenine dye covalently bound with glucose (TICS). under acidification of tumor cells environment
KR102822996B1 (ko) 디셀레나이드 함유 탄화수소를 포함하고 미토콘드리아 표적형 초음파감작제가 탑재된 ros/gsh 이중 감응성 세포 외 소포체 및 이를 이용한 초음파역학 치료제
Xin Molecular fluorescent and chemiluminescent probes for cancer diagnosis and therapy
CA3006018C (en) Microbubble-chemotherapeutic agent complex for sonodynamic therapy
Короткова et al. Nanoparticles-based photosensitizers with effect of aggregation-induced emission

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210408

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 9TH ANNIV.) - STANDARD

Year of fee payment: 9

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250318

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20250318

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250318

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 10TH ANNIV.) - STANDARD

Year of fee payment: 10

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20260303

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20260303