CA2979309A1 - Glutamate oxaloacetate transaminase 1 (got1), preparations and methods of generating same and uses thereof - Google Patents
Glutamate oxaloacetate transaminase 1 (got1), preparations and methods of generating same and uses thereof Download PDFInfo
- Publication number
- CA2979309A1 CA2979309A1 CA2979309A CA2979309A CA2979309A1 CA 2979309 A1 CA2979309 A1 CA 2979309A1 CA 2979309 A CA2979309 A CA 2979309A CA 2979309 A CA2979309 A CA 2979309A CA 2979309 A1 CA2979309 A1 CA 2979309A1
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- Prior art keywords
- got1
- sumo
- fusion protein
- polypeptide
- protein
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Classifications
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/303—Extraction; Separation; Purification by precipitation by salting out
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01001—Aspartate transaminase (2.6.1.1), i.e. aspartate-aminotransferase
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
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| US201562140492P | 2015-03-31 | 2015-03-31 | |
| US62/140,492 | 2015-03-31 | ||
| PCT/IL2016/050346 WO2016157190A1 (en) | 2015-03-31 | 2016-03-31 | Glutamate oxaloacetate transaminase 1 (got1), preparations and methods of generating same and uses thereof |
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| CA2979309A1 true CA2979309A1 (en) | 2016-10-06 |
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| RU2712193C1 (ru) * | 2018-07-27 | 2020-01-24 | Общество с ограниченной ответственностью научно-технический центр "БиоКлиникум" (ООО НТЦ "БиоКлиникум") | Способ лечения поражения нервной системы с помощью рекомбинантной глутаматоксалоацетаттрансаминазы |
| US11740211B2 (en) * | 2020-01-31 | 2023-08-29 | Waters Technologies Corporation | LC/MS adduct mitigation by vapor deposition coated surfaces |
| CN116143898B (zh) * | 2023-01-30 | 2026-03-24 | 翌圣生物科技(上海)股份有限公司 | 骨形态发生蛋白bmp-2重组蛋白、编码基因及其原核表达方法 |
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| WO2026139625A1 (en) | 2024-12-26 | 2026-07-02 | Alternative Gene Expression S.L. | Glutamate-oxaloacetate transaminase (got1) – fc (fragment crystallizable) fusion proteins |
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| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
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| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| DE60318014T2 (de) * | 2002-01-07 | 2008-11-27 | Lifesensors, Inc. | Verfahren und zusammensetzungen für die proteinexpression und reinigung |
| CA2494348C (en) * | 2002-08-01 | 2014-04-08 | Yeda Research And Development Co. Ltd. | Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels |
| GB0315248D0 (en) * | 2003-06-30 | 2003-08-06 | Hoffmann La Roche | HCV regulated protein expression |
| WO2006069610A2 (en) * | 2004-07-02 | 2006-07-06 | Metanomics Gmbh | Process for the production of fine chemicals |
| EP2096177A3 (en) * | 2004-12-17 | 2010-01-13 | Metanomics GmbH | Process for the production of lutein |
| EP1836214A4 (en) | 2004-12-30 | 2009-01-21 | Lifesensors Inc | COMPOSITIONS, METHODS, AND KITS FOR IMPROVING PROTEIN EXPRESSION, SOLUBILITY, AND ISOLATION |
| CA2670014A1 (en) * | 2006-11-22 | 2008-11-20 | Emory University | Production of anti-microbial peptides |
| CA2674304C (en) * | 2006-12-29 | 2016-02-23 | Lifesensors, Inc. | Methods and compositions for enhanced protein expression and purification |
| ES2534936T3 (es) * | 2010-08-02 | 2015-04-30 | Ratiopharm Gmbh | Método para producir y purificar una sialiltransferasa soluble activa |
| WO2012159782A1 (en) * | 2011-05-24 | 2012-11-29 | Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune | High affinity sumo traps |
-
2016
- 2016-03-31 KR KR1020177031382A patent/KR20170132293A/ko not_active Withdrawn
- 2016-03-31 BR BR112017021016-9A patent/BR112017021016A2/pt not_active Application Discontinuation
- 2016-03-31 RU RU2017135552A patent/RU2017135552A/ru not_active Application Discontinuation
- 2016-03-31 JP JP2017550936A patent/JP2018511325A/ja active Pending
- 2016-03-31 CA CA2979309A patent/CA2979309A1/en not_active Abandoned
- 2016-03-31 WO PCT/IL2016/050346 patent/WO2016157190A1/en not_active Ceased
- 2016-03-31 HK HK18102801.5A patent/HK1243329A1/zh unknown
- 2016-03-31 CN CN201680031560.0A patent/CN107771217A/zh active Pending
- 2016-03-31 EP EP16717478.8A patent/EP3277308A1/en not_active Withdrawn
- 2016-03-31 AU AU2016242298A patent/AU2016242298A1/en not_active Abandoned
- 2016-03-31 US US15/561,053 patent/US20180071369A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017135552A3 (cg-RX-API-DMAC10.html) | 2019-07-24 |
| HK1243329A1 (zh) | 2018-07-13 |
| JP2018511325A (ja) | 2018-04-26 |
| US20180071369A1 (en) | 2018-03-15 |
| RU2017135552A (ru) | 2019-04-30 |
| CN107771217A (zh) | 2018-03-06 |
| WO2016157190A1 (en) | 2016-10-06 |
| KR20170132293A (ko) | 2017-12-01 |
| BR112017021016A2 (pt) | 2018-07-03 |
| AU2016242298A1 (en) | 2017-10-19 |
| EP3277308A1 (en) | 2018-02-07 |
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