CA2977423A1 - Genetically modified nk-92 cells and monoclonal antibodies for the treatment of cancer - Google Patents

Genetically modified nk-92 cells and monoclonal antibodies for the treatment of cancer Download PDF

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Publication number
CA2977423A1
CA2977423A1 CA2977423A CA2977423A CA2977423A1 CA 2977423 A1 CA2977423 A1 CA 2977423A1 CA 2977423 A CA2977423 A CA 2977423A CA 2977423 A CA2977423 A CA 2977423A CA 2977423 A1 CA2977423 A1 CA 2977423A1
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Canada
Prior art keywords
cells
leu
fcr
expressing
monoclonal antibody
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Pending
Application number
CA2977423A
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English (en)
French (fr)
Inventor
Tien Lee
Hans G. KLINGEMANN
Barry J. SIMON
Laurent BOISSEL
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Immunitybio Inc
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NantKwest Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57006343&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2977423(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by NantKwest Inc filed Critical NantKwest Inc
Publication of CA2977423A1 publication Critical patent/CA2977423A1/en
Pending legal-status Critical Current

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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CA2977423A 2015-03-27 2016-03-25 Genetically modified nk-92 cells and monoclonal antibodies for the treatment of cancer Pending CA2977423A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562139258P 2015-03-27 2015-03-27
US62/139,258 2015-03-27
PCT/US2016/024318 WO2016160602A2 (en) 2015-03-27 2016-03-25 Genetically modified nk-92 cells and monoclonal antibodies for the treatment of cancer

Publications (1)

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CA2977423A1 true CA2977423A1 (en) 2016-10-06

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ID=57006343

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Application Number Title Priority Date Filing Date
CA2977423A Pending CA2977423A1 (en) 2015-03-27 2016-03-25 Genetically modified nk-92 cells and monoclonal antibodies for the treatment of cancer

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Country Link
US (6) US10456420B2 (enExample)
EP (1) EP3273993A4 (enExample)
JP (5) JP6748105B2 (enExample)
KR (3) KR102460387B1 (enExample)
CN (4) CN114533867A (enExample)
AU (3) AU2016243120B2 (enExample)
CA (1) CA2977423A1 (enExample)
HK (2) HK1247117A1 (enExample)
IL (4) IL294982B2 (enExample)
WO (1) WO2016160602A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3273993A4 (en) 2015-03-27 2018-11-07 Nantkwest, Inc. Genetically modified nk-92 cells and monoclonal antibodies for the treatment of cancer
JP7178906B2 (ja) 2016-05-19 2022-11-28 ザ ジェネラル ホスピタル コーポレイション ナチュラルキラー細胞および制御性Ｔ細胞の活性を強化するためのプラットフォームである、その受容体ＩＬ－２Ｒβに繋ぎ止められたインターロイキン－２
CA3042238C (en) * 2016-10-28 2021-08-10 Nant Holdings Ip, Llc Avatar dendritic cells: the neoantigen natural killer t-cell chemo immuno radiation composition inducing immunogenic cell death
US20180221463A1 (en) * 2017-01-13 2018-08-09 The Chinese University Of Hong Kong Modified NK Cells and Uses Thereof
CN110418839B (zh) * 2017-03-08 2023-06-09 免疫生物公司 用于临床的修饰的NK-92haNK003细胞
CA3128202A1 (en) * 2017-05-11 2018-11-15 Nantkwest, Inc. Anti-egfr/high affinity nk-cells compositions and methods for chordoma treatment
WO2019201629A1 (en) * 2018-04-19 2019-10-24 Onkimmune Limited Nk cells for use with antibodies in cancer therapy
CN108531458A (zh) * 2018-04-27 2018-09-14 赛诺（深圳）生物医药研究有限公司 治疗肿瘤的基因工程自然杀伤细胞产品
WO2020014245A1 (en) 2018-07-10 2020-01-16 Nantkwest, Inc. Cryopreservation
JP7241161B2 (ja) 2018-08-01 2023-03-16 イミュニティーバイオ、インコーポレイテッド 細胞免疫療法の安定した遺伝子改変のための、ホーミング受容体又はサイトカインとキメラ抗原受容体とを含むクアドリシストロニックシステム
CN118976120A (zh) * 2018-09-07 2024-11-19 南特生物公司 刺激hank和nk92mi细胞的靶向il-12治疗和方法
CA3092709A1 (en) 2018-10-31 2020-05-07 Nantkwest, Inc. Elimination of cd19-positive lymphoid malignancies by cd19-car expressing nk cells
KR102533540B1 (ko) * 2018-10-31 2023-05-17 난트퀘스트, 인크. Pd-l1 키메라 항원 수용체-발현 nk 세포에 의한 pd-l1-양성 악성종양의 제거(elimination of pd-l1-positive malignancies by pd-l1 chimeric antigen receptor-expressing nk cells)
CA3117936A1 (en) * 2018-11-26 2020-06-04 Immunitybio, Inc. Il-2 dependent nk-92 cells with stable fc receptor expression
CN119040363A (zh) 2019-03-15 2024-11-29 河谷细胞有限公司 重组erIL-15 NK细胞
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