CA2975877A1 - Procede de synthese pour la preparation de 5-tetradecyloxy)furan-2-carboxylate de 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyle - Google Patents

Procede de synthese pour la preparation de 5-tetradecyloxy)furan-2-carboxylate de 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyle Download PDF

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Publication number
CA2975877A1
CA2975877A1 CA2975877A CA2975877A CA2975877A1 CA 2975877 A1 CA2975877 A1 CA 2975877A1 CA 2975877 A CA2975877 A CA 2975877A CA 2975877 A CA2975877 A CA 2975877A CA 2975877 A1 CA2975877 A1 CA 2975877A1
Authority
CA
Canada
Prior art keywords
solvent
formula
compound
oxoethyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2975877A
Other languages
English (en)
Inventor
Anthony Adrian Shaw
Kanjai Khumtaveeporn
Pavel Krasik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dermira Inc
Original Assignee
Dermira Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dermira Inc filed Critical Dermira Inc
Publication of CA2975877A1 publication Critical patent/CA2975877A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne des procédés de formation de 5-tétradécyloxy)furan-2-carboxylate de 2-((2-éthoxy-2-oxoéthyl)(méthyl)amino)-2-oxoéthyle: Formule (I).
CA2975877A 2015-02-05 2016-02-04 Procede de synthese pour la preparation de 5-tetradecyloxy)furan-2-carboxylate de 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyle Abandoned CA2975877A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562112569P 2015-02-05 2015-02-05
US62/112,569 2015-02-05
PCT/US2016/016616 WO2016126973A1 (fr) 2015-02-05 2016-02-04 Procédé de synthèse pour la préparation de 5-tétradécyloxy)furan-2-carboxylate de 2-((2-éthoxy-2-oxoéthyl)(méthyl)amino)-2-oxoéthyle

Publications (1)

Publication Number Publication Date
CA2975877A1 true CA2975877A1 (fr) 2016-08-11

Family

ID=55404838

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2975877A Abandoned CA2975877A1 (fr) 2015-02-05 2016-02-04 Procede de synthese pour la preparation de 5-tetradecyloxy)furan-2-carboxylate de 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyle

Country Status (10)

Country Link
US (2) US9487497B2 (fr)
EP (1) EP3253742B1 (fr)
JP (1) JP6626113B2 (fr)
KR (1) KR20170113590A (fr)
CN (1) CN107406400B (fr)
AU (1) AU2016215228A1 (fr)
CA (1) CA2975877A1 (fr)
ES (1) ES2802465T3 (fr)
HK (1) HK1243706A1 (fr)
WO (1) WO2016126973A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9487497B2 (en) * 2015-02-05 2016-11-08 Dermira Inc. Synthetic process for preparing 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-tetradecyloxy)furan-2-carboxylate
TW201811307A (zh) * 2016-07-26 2018-04-01 美商德米拉股份有限公司 2-(2-乙氧基-2-氧代乙基)(甲基)胺基-2-氧代乙基5-(十四烷氧基)呋喃-2-羧酸酯之皮膚調配物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4033563A1 (de) 1990-10-22 1992-04-23 Henkel Kgaa Antiseborrhoische zubereitungen
US20060241177A1 (en) * 2002-07-01 2006-10-26 Kuhadja Francis P Novel compounds, pharmaceutical compositions containing same, and methods of use for same
US20100204317A1 (en) 2006-11-03 2010-08-12 Qlt Inc. Methods of treating dermatological disorders or conditions
DK2451796T3 (da) 2009-07-08 2013-07-29 Dermira Canada Inc Tofaanaloger til behandling af dermatologiske lidelser eller tilstande
US8697739B2 (en) * 2010-07-29 2014-04-15 Novartis Ag Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof
US9487497B2 (en) * 2015-02-05 2016-11-08 Dermira Inc. Synthetic process for preparing 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-tetradecyloxy)furan-2-carboxylate

Also Published As

Publication number Publication date
JP2018504442A (ja) 2018-02-15
CN107406400B (zh) 2020-08-04
US20160229826A1 (en) 2016-08-11
US9487497B2 (en) 2016-11-08
CN107406400A (zh) 2017-11-28
EP3253742A1 (fr) 2017-12-13
KR20170113590A (ko) 2017-10-12
JP6626113B2 (ja) 2019-12-25
WO2016126973A1 (fr) 2016-08-11
US9745277B2 (en) 2017-08-29
EP3253742B1 (fr) 2020-04-08
AU2016215228A1 (en) 2017-08-10
ES2802465T3 (es) 2021-01-19
US20170022176A1 (en) 2017-01-26
HK1243706A1 (zh) 2018-07-20

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20220426

FZDE Discontinued

Effective date: 20220426