CA2969551C - Bifunctional do2pa derivatives, chelates with metallic cations and use thereof - Google Patents
Bifunctional do2pa derivatives, chelates with metallic cations and use thereof Download PDFInfo
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- CA2969551C CA2969551C CA2969551A CA2969551A CA2969551C CA 2969551 C CA2969551 C CA 2969551C CA 2969551 A CA2969551 A CA 2969551A CA 2969551 A CA2969551 A CA 2969551A CA 2969551 C CA2969551 C CA 2969551C
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Classifications
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/24—Lead compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
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Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
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- Veterinary Medicine (AREA)
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- Biochemistry (AREA)
- Molecular Biology (AREA)
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- General Chemical & Material Sciences (AREA)
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- Toxicology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14196637.4A EP3029032A1 (de) | 2014-12-05 | 2014-12-05 | Bifunktionelle Do2pa-Derivate, Chelate mit metallischen Kationen und Verwendung davon |
| EP14196637.4 | 2014-12-05 | ||
| PCT/EP2015/078732 WO2016087667A1 (en) | 2014-12-05 | 2015-12-04 | BIFUNCTIONAL do2pa DERIVATIVES, CHELATES WITH METALLIC CATIONS AND USE THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2969551A1 CA2969551A1 (en) | 2016-06-09 |
| CA2969551C true CA2969551C (en) | 2024-02-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2969551A Active CA2969551C (en) | 2014-12-05 | 2015-12-04 | Bifunctional do2pa derivatives, chelates with metallic cations and use thereof |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20170326261A1 (de) |
| EP (3) | EP3029032A1 (de) |
| CA (1) | CA2969551C (de) |
| ES (1) | ES2892955T3 (de) |
| WO (1) | WO2016087667A1 (de) |
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| JP6412918B2 (ja) | 2013-03-15 | 2018-10-24 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | マルチモーダルシリカ系ナノ粒子 |
| CA2985126A1 (en) | 2015-05-29 | 2016-12-08 | Cornell University | Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis |
| JP2020520953A (ja) | 2017-05-25 | 2020-07-16 | メモリアル スローン ケタリング キャンサー センター | ジルコニウム−８９で標識した超小型ナノ粒子およびその方法 |
| WO2019246445A1 (en) * | 2018-06-20 | 2019-12-26 | The Research Foundation For The State University Of New York | Triazamacrocycle-derived chelator compositions for coordination of imaging and therapy metal ions and methods of using same |
| CN113056288A (zh) * | 2018-11-20 | 2021-06-29 | 康奈尔大学 | 放射性核素的大环配合物及其在癌症的放射治疗中的应用 |
| CN114409578B (zh) * | 2022-01-28 | 2022-10-14 | 安源基因科技(上海)有限公司 | 一种多元适体分子的制备方法 |
| CN114441749B (zh) * | 2022-01-28 | 2022-09-30 | 安源基因科技(上海)有限公司 | 一种新型多元适体分子在磁珠免疫化学发光afp中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5006643A (en) * | 1987-06-24 | 1991-04-09 | The Dow Chemical Company | Process for preparing isothiocyanato functionalized metal complexes |
| US4994560A (en) * | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
| US5756065A (en) * | 1988-06-24 | 1998-05-26 | The Dow Chemical Company | Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| FR3006688B1 (fr) * | 2013-06-06 | 2015-08-14 | Centre Nat Rech Scient | Chelates du plomb (ii) et du bismuth (iii) a base de tetraazacycloalcanes trans-di-n-picolinates |
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2014
- 2014-12-05 EP EP14196637.4A patent/EP3029032A1/de not_active Withdrawn
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2015
- 2015-12-04 US US15/533,204 patent/US20170326261A1/en not_active Abandoned
- 2015-12-04 WO PCT/EP2015/078732 patent/WO2016087667A1/en active Application Filing
- 2015-12-04 EP EP21176589.6A patent/EP3909948B1/de active Active
- 2015-12-04 ES ES15807634T patent/ES2892955T3/es active Active
- 2015-12-04 CA CA2969551A patent/CA2969551C/en active Active
- 2015-12-04 EP EP15807634.9A patent/EP3227272B1/de active Active
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2019
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2022
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2969551A1 (en) | 2016-06-09 |
| US20220143230A1 (en) | 2022-05-12 |
| EP3029032A1 (de) | 2016-06-08 |
| EP3227272A1 (de) | 2017-10-11 |
| EP3909948A1 (de) | 2021-11-17 |
| EP3227272B1 (de) | 2021-07-07 |
| US11266754B2 (en) | 2022-03-08 |
| WO2016087667A1 (en) | 2016-06-09 |
| ES2892955T3 (es) | 2022-02-07 |
| EP3909948B1 (de) | 2024-02-28 |
| US20200038527A1 (en) | 2020-02-06 |
| US20170326261A1 (en) | 2017-11-16 |
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