CA2966642C - Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma - Google Patents
Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma Download PDFInfo
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- CA2966642C CA2966642C CA2966642A CA2966642A CA2966642C CA 2966642 C CA2966642 C CA 2966642C CA 2966642 A CA2966642 A CA 2966642A CA 2966642 A CA2966642 A CA 2966642A CA 2966642 C CA2966642 C CA 2966642C
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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| US201462076980P | 2014-11-07 | 2014-11-07 | |
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| PCT/US2015/059738 WO2016073983A2 (en) | 2014-11-07 | 2015-11-09 | Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma |
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| US10822301B2 (en) | 2018-04-12 | 2020-11-03 | Northwestern University | 3-carbon substituted 4-aminocyclopent-1-ene-1-carboxylic acid compounds as inhibitors of gamma-aminobutyric acid (GABA) aminotransferase |
| FI3784649T3 (fi) * | 2018-05-25 | 2024-08-22 | Univ Northwestern | Prosessi (S)-3-amino-4-(difluorimetylenyyli)syklopent-1-eeni-1-karboksyylihapon synteesiä varten |
| AU2019280980B2 (en) | 2018-06-07 | 2025-02-27 | Ovid Therapeutics Inc. | Use of (S)-3-amino-4-(difluoromethylenyl) cyclopent-1-ene-1-carboxylic acid and related compounds, (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid and vigabatrin in the treatment of developmental disorders |
| US11203596B2 (en) | 2019-02-25 | 2021-12-21 | Northwestern University | Analogs of 3-amino-4-(propan-2-ylidene)cyclopentane-1-carboxylic acid and uses thereof for treating diseases and disorders associated with ornithine aminotransferase activity |
| US11078153B2 (en) * | 2019-04-03 | 2021-08-03 | Northwestern University | 2-difluoro substituted 4-aminocyclopentanecarboxylic acids as inhibitors of gamma-aminobutyric acid aminotransferase and human ornithine aminotransferase |
| US11993569B2 (en) | 2020-01-23 | 2024-05-28 | Northwestern University | 3-amino-4-halocyclopentene carboxylic acids as inactivators of aminotransferases |
| US20240174596A1 (en) * | 2021-03-03 | 2024-05-30 | Northwestern University | (s)-3-amino-4,4-dihalocyclopent-1-enecarboxylic acid as selective inactivators of human ornithine aminotransferase |
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| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| IL177609A (en) | 2006-08-21 | 2015-11-30 | Yaron Ilan | Use of gobacoline or its analogue to produce a drug to treat liver carcinoma |
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| JP2017533964A (ja) | 2017-11-16 |
| CA2966642A1 (en) | 2016-05-12 |
| AU2015342801A1 (en) | 2017-05-18 |
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| US20160128958A1 (en) | 2016-05-12 |
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| WO2016073983A3 (en) | 2016-08-11 |
| IL252042B (en) | 2020-05-31 |
| WO2016073983A2 (en) | 2016-05-12 |
| JP6867949B2 (ja) | 2021-05-12 |
| EP3215144A4 (en) | 2018-06-20 |
| ES2882126T3 (es) | 2021-12-01 |
| EP3215144A2 (en) | 2017-09-13 |
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