CA2965325A1 - Method of treating patients with hepatorenal syndrome type 1 - Google Patents
Method of treating patients with hepatorenal syndrome type 1 Download PDFInfo
- Publication number
- CA2965325A1 CA2965325A1 CA2965325A CA2965325A CA2965325A1 CA 2965325 A1 CA2965325 A1 CA 2965325A1 CA 2965325 A CA2965325 A CA 2965325A CA 2965325 A CA2965325 A CA 2965325A CA 2965325 A1 CA2965325 A1 CA 2965325A1
- Authority
- CA
- Canada
- Prior art keywords
- patient
- terlipressin
- criteria
- treatment
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 82
- 201000011200 hepatorenal syndrome Diseases 0.000 title claims description 72
- 108010010056 Terlipressin Proteins 0.000 claims abstract description 245
- 229960003813 terlipressin Drugs 0.000 claims abstract description 245
- BENFXAYNYRLAIU-QSVFAHTRSA-N terlipressin Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CN)CSSC1 BENFXAYNYRLAIU-QSVFAHTRSA-N 0.000 claims abstract description 245
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims abstract description 136
- 229940109239 creatinine Drugs 0.000 claims abstract description 68
- 210000002966 serum Anatomy 0.000 claims abstract description 63
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims abstract description 61
- 230000009467 reduction Effects 0.000 claims abstract description 20
- 206010062237 Renal impairment Diseases 0.000 claims abstract description 11
- 231100000857 poor renal function Toxicity 0.000 claims abstract description 10
- 208000019423 liver disease Diseases 0.000 claims abstract description 6
- 238000011282 treatment Methods 0.000 claims description 116
- 210000004027 cell Anatomy 0.000 claims description 59
- 210000000265 leukocyte Anatomy 0.000 claims description 48
- 208000015181 infectious disease Diseases 0.000 claims description 37
- 206010040047 Sepsis Diseases 0.000 claims description 26
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 26
- 206010016654 Fibrosis Diseases 0.000 claims description 25
- 230000007882 cirrhosis Effects 0.000 claims description 25
- 230000003907 kidney function Effects 0.000 claims description 24
- 238000004820 blood count Methods 0.000 claims description 22
- 206010040070 Septic Shock Diseases 0.000 claims description 21
- 230000036303 septic shock Effects 0.000 claims description 21
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 20
- 210000004369 blood Anatomy 0.000 claims description 16
- 239000008280 blood Substances 0.000 claims description 16
- 238000012360 testing method Methods 0.000 claims description 16
- 206010057573 Chronic hepatic failure Diseases 0.000 claims description 14
- 208000010334 End Stage Liver Disease Diseases 0.000 claims description 14
- 208000011444 chronic liver failure Diseases 0.000 claims description 14
- 210000004185 liver Anatomy 0.000 claims description 14
- 230000003247 decreasing effect Effects 0.000 claims description 13
- 102000009027 Albumins Human genes 0.000 claims description 12
- 108010088751 Albumins Proteins 0.000 claims description 12
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 10
- 239000001569 carbon dioxide Substances 0.000 claims description 10
- 230000036961 partial effect Effects 0.000 claims description 9
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims description 7
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 claims description 6
- 108010004977 Vasopressins Proteins 0.000 claims description 6
- 102000002852 Vasopressins Human genes 0.000 claims description 6
- 208000008203 tachypnea Diseases 0.000 claims description 6
- 206010043089 tachypnoea Diseases 0.000 claims description 6
- 229960003726 vasopressin Drugs 0.000 claims description 6
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims description 4
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims description 4
- PTKSEFOSCHHMPD-SNVBAGLBSA-N 2-amino-n-[(2s)-2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide Chemical compound COC1=CC=C(OC)C([C@H](O)CNC(=O)CN)=C1 PTKSEFOSCHHMPD-SNVBAGLBSA-N 0.000 claims description 4
- 108010016076 Octreotide Proteins 0.000 claims description 4
- 238000000502 dialysis Methods 0.000 claims description 4
- 230000000977 initiatory effect Effects 0.000 claims description 4
- 229960001094 midodrine Drugs 0.000 claims description 4
- 229960002748 norepinephrine Drugs 0.000 claims description 4
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims description 4
- 229960002700 octreotide Drugs 0.000 claims description 4
- 210000003734 kidney Anatomy 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 229940127557 pharmaceutical product Drugs 0.000 claims description 3
- 101100205030 Caenorhabditis elegans hars-1 gene Proteins 0.000 abstract description 51
- 230000004044 response Effects 0.000 description 63
- 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 description 34
- 238000001990 intravenous administration Methods 0.000 description 14
- 230000006872 improvement Effects 0.000 description 12
- 206010003445 Ascites Diseases 0.000 description 9
- 208000001647 Renal Insufficiency Diseases 0.000 description 9
- 201000006370 kidney failure Diseases 0.000 description 9
- 238000003745 diagnosis Methods 0.000 description 8
- 230000001747 exhibiting effect Effects 0.000 description 8
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 239000000902 placebo Substances 0.000 description 7
- 229940068196 placebo Drugs 0.000 description 7
- 230000029058 respiratory gaseous exchange Effects 0.000 description 7
- 230000001154 acute effect Effects 0.000 description 5
- 229940024606 amino acid Drugs 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000024883 vasodilation Effects 0.000 description 5
- 108010048179 Lypressin Proteins 0.000 description 4
- 206010047139 Vasoconstriction Diseases 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000002440 hepatic effect Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000010837 poor prognosis Methods 0.000 description 4
- 230000008718 systemic inflammatory response Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 230000025033 vasoconstriction Effects 0.000 description 4
- 208000009304 Acute Kidney Injury Diseases 0.000 description 3
- 206010016803 Fluid overload Diseases 0.000 description 3
- 208000033626 Renal failure acute Diseases 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 201000011040 acute kidney failure Diseases 0.000 description 3
- 230000002924 anti-infective effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 230000007717 exclusion Effects 0.000 description 3
- 208000007232 portal hypertension Diseases 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 208000007788 Acute Liver Failure Diseases 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- 208000009079 Bronchial Spasm Diseases 0.000 description 2
- 208000014181 Bronchial disease Diseases 0.000 description 2
- 206010006482 Bronchospasm Diseases 0.000 description 2
- 208000028399 Critical Illness Diseases 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 206010019663 Hepatic failure Diseases 0.000 description 2
- 208000001953 Hypotension Diseases 0.000 description 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 206010037423 Pulmonary oedema Diseases 0.000 description 2
- 229960004308 acetylcysteine Drugs 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000036757 core body temperature Effects 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 230000024924 glomerular filtration Effects 0.000 description 2
- 230000036543 hypotension Effects 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 238000004750 isotope dilution mass spectroscopy Methods 0.000 description 2
- 208000007903 liver failure Diseases 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 description 2
- 229960005249 misoprostol Drugs 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 239000002831 pharmacologic agent Substances 0.000 description 2
- 238000011422 pharmacological therapy Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 208000005333 pulmonary edema Diseases 0.000 description 2
- 230000008085 renal dysfunction Effects 0.000 description 2
- 230000036387 respiratory rate Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- BJFIDCADFRDPIO-DZCXQCEKSA-N (2S)-N-[(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-13-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloeicos-4-yl]-oxomethyl]-2-pyrrolidinecarboxamide Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](N)CSSC1 BJFIDCADFRDPIO-DZCXQCEKSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- OXDZADMCOWPSOC-UHFFFAOYSA-N Argiprestocin Chemical class N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 OXDZADMCOWPSOC-UHFFFAOYSA-N 0.000 description 1
- 206010072081 Bandaemia Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 108010069514 Cyclic Peptides Proteins 0.000 description 1
- 102000001189 Cyclic Peptides Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000032274 Encephalopathy Diseases 0.000 description 1
- 229940118365 Endothelin receptor antagonist Drugs 0.000 description 1
- 206010020660 Hyperlactacidaemia Diseases 0.000 description 1
- 208000005018 Hyperlactatemia Diseases 0.000 description 1
- 206010021036 Hyponatraemia Diseases 0.000 description 1
- 206010058558 Hypoperfusion Diseases 0.000 description 1
- 206010021137 Hypovolaemia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010022680 Intestinal ischaemia Diseases 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- UXIGWFXRQKWHHA-UHFFFAOYSA-N Iotalamic acid Chemical compound CNC(=O)C1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I UXIGWFXRQKWHHA-UHFFFAOYSA-N 0.000 description 1
- 238000007375 Jaffe assay Methods 0.000 description 1
- 239000004395 L-leucine Substances 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010047141 Vasodilatation Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000012998 acute renal failure Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 229940050528 albumin Drugs 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000002517 constrictor effect Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 125000004122 cyclic group Chemical class 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 230000008339 endometrial blood flow Effects 0.000 description 1
- 239000002308 endothelin receptor antagonist Substances 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000002637 fluid replacement therapy Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- -1 glycyl-amino Chemical class 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 description 1
- 229960001025 iohexol Drugs 0.000 description 1
- 229940029378 iothalamate Drugs 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 229960003837 lypressin Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229940075930 picrate Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000007430 reference method Methods 0.000 description 1
- 238000012959 renal replacement therapy Methods 0.000 description 1
- 229940124550 renal vasodilator Drugs 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 206010041232 sneezing Diseases 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000002550 vasoactive agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/024—Measuring pulse rate or heart rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
- A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4925—Blood measuring blood gas content, e.g. O2, CO2, HCO3
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/016—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1024—Counting particles by non-optical means
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Surgery (AREA)
- Physiology (AREA)
- Medical Informatics (AREA)
- Ecology (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462068357P | 2014-10-24 | 2014-10-24 | |
| US62/068,357 | 2014-10-24 | ||
| US201562151384P | 2015-04-22 | 2015-04-22 | |
| US62/151,384 | 2015-04-22 | ||
| PCT/US2015/056861 WO2016065117A1 (en) | 2014-10-24 | 2015-10-22 | Method of treating patients with hepatorenal syndrome type 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2965325A1 true CA2965325A1 (en) | 2016-04-28 |
Family
ID=54478246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2965325A Abandoned CA2965325A1 (en) | 2014-10-24 | 2015-10-22 | Method of treating patients with hepatorenal syndrome type 1 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10335452B2 (enExample) |
| EP (3) | EP3981420A1 (enExample) |
| JP (4) | JP6673915B2 (enExample) |
| CN (2) | CN107206049B (enExample) |
| AU (1) | AU2015335855A1 (enExample) |
| CA (1) | CA2965325A1 (enExample) |
| DK (2) | DK3209317T3 (enExample) |
| ES (2) | ES2904492T3 (enExample) |
| FI (1) | FI3978074T3 (enExample) |
| HR (1) | HRP20220225T1 (enExample) |
| HU (1) | HUE058066T2 (enExample) |
| PL (2) | PL3209317T3 (enExample) |
| PT (2) | PT3978074T (enExample) |
| SI (1) | SI3209317T1 (enExample) |
| WO (1) | WO2016065117A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20170929T1 (hr) | 2008-09-17 | 2017-09-22 | Chiasma Inc. | Farmaceutski pripravci i odgovarajući postupci za isporuku |
| US20200046798A1 (en) * | 2014-10-24 | 2020-02-13 | Mallinckrodt Hospital Products IP Limited | Method of treating patients with hepatorenal syndrome type 1 |
| US20210290725A1 (en) * | 2014-10-24 | 2021-09-23 | Mallinckrodt Pharmaceuticals Ireland Limited | Method of treating patients with hepatorenal syndrome type 1 |
| JP6673915B2 (ja) * | 2014-10-24 | 2020-03-25 | マリンクロット ホスピタル プロダクツ アイピー リミテッド | １型肝腎症候群患者の治療方法 |
| EP3528828B1 (en) * | 2016-10-21 | 2025-01-29 | Amryt Endo, Inc. | Terlipressin composition for use in treating ascites |
| KR20220011697A (ko) | 2019-05-22 | 2022-01-28 | 바이오비에 아이앤씨. | 테를리프레신 제형 |
| CN110251469B (zh) * | 2019-07-31 | 2021-11-09 | 南京康舟医药科技有限公司 | 一种醋酸特利加压素制剂及其制备方法 |
| WO2021084483A1 (en) * | 2019-10-30 | 2021-05-06 | Mallinckrodt Hospital Products IP Unlimited Company | Method of treating patients with hepatorenal syndrome type 1 and low mean arterial pressure |
| WO2023183339A1 (en) * | 2022-03-22 | 2023-09-28 | Ocelot Bio, Inc. | Selective vasopressin receptor agonist for end-stage liver disease |
| US20240156895A1 (en) * | 2022-10-28 | 2024-05-16 | Mallinckrodt Pharmaceuticals Ireland Limited | Compositions for improving kidney function in patients with hepatorenal syndrome |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1188443A1 (en) | 2000-09-15 | 2002-03-20 | Ferring BV | Improved protocol for paracentesis |
| US7785857B2 (en) * | 2006-08-31 | 2010-08-31 | Saint Louis University | Protein C variant |
| GB0617581D0 (en) * | 2006-09-07 | 2006-10-18 | Ucl Business Plc | Biomarkers for assessing liver function |
| US20080221551A1 (en) * | 2007-03-09 | 2008-09-11 | Flowmedica, Inc. | Acute kidney injury treatment systems and methods |
| US9050286B2 (en) | 2007-08-14 | 2015-06-09 | Ferring B.V. | Use of peptidic vasopression receptor agonists |
| EP2913676A1 (en) * | 2008-11-10 | 2015-09-02 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| ES2661310T3 (es) | 2009-03-09 | 2018-03-28 | Bioatla, Llc | Proteínas mirac |
| AU2010258888B2 (en) | 2009-06-08 | 2014-08-07 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| AU2011279144A1 (en) * | 2010-07-14 | 2013-01-24 | Cumberland Emerging Technologies, Inc | Methods of treating hepatorenal syndrome and hepatic encephalopathy with thromboxane-A2 receptor antagonists |
| JP2012159356A (ja) * | 2011-01-31 | 2012-08-23 | Mochida Pharmaceut Co Ltd | 敗血症診断用組合せマーカー |
| CN103254295A (zh) * | 2013-05-31 | 2013-08-21 | 青岛国大生物制药股份有限公司 | 特利加压素的制备方法 |
| JP6673915B2 (ja) * | 2014-10-24 | 2020-03-25 | マリンクロット ホスピタル プロダクツ アイピー リミテッド | １型肝腎症候群患者の治療方法 |
| JP2017014206A (ja) | 2015-06-30 | 2017-01-19 | ナノアンティバイオティクス，インコーポレイテッド | 腹水の治療 |
-
2015
- 2015-10-22 JP JP2017521988A patent/JP6673915B2/ja active Active
- 2015-10-22 US US14/920,392 patent/US10335452B2/en active Active
- 2015-10-22 ES ES15791430T patent/ES2904492T3/es active Active
- 2015-10-22 SI SI201531790T patent/SI3209317T1/sl unknown
- 2015-10-22 ES ES21205752T patent/ES2987577T3/es active Active
- 2015-10-22 PT PT212057525T patent/PT3978074T/pt unknown
- 2015-10-22 DK DK15791430.0T patent/DK3209317T3/da active
- 2015-10-22 HR HRP20220225TT patent/HRP20220225T1/hr unknown
- 2015-10-22 DK DK21205752.5T patent/DK3978074T3/da active
- 2015-10-22 PT PT157914300T patent/PT3209317T/pt unknown
- 2015-10-22 CN CN201580062745.3A patent/CN107206049B/zh active Active
- 2015-10-22 CN CN202111342532.XA patent/CN114028536B/zh active Active
- 2015-10-22 EP EP21208813.2A patent/EP3981420A1/en active Pending
- 2015-10-22 CA CA2965325A patent/CA2965325A1/en not_active Abandoned
- 2015-10-22 PL PL15791430T patent/PL3209317T3/pl unknown
- 2015-10-22 EP EP21205752.5A patent/EP3978074B1/en active Active
- 2015-10-22 WO PCT/US2015/056861 patent/WO2016065117A1/en not_active Ceased
- 2015-10-22 EP EP15791430.0A patent/EP3209317B1/en active Active
- 2015-10-22 HU HUE15791430A patent/HUE058066T2/hu unknown
- 2015-10-22 FI FIEP21205752.5T patent/FI3978074T3/fi active
- 2015-10-22 AU AU2015335855A patent/AU2015335855A1/en not_active Abandoned
- 2015-10-22 PL PL21205752.5T patent/PL3978074T3/pl unknown
-
2019
- 2019-05-14 US US16/411,944 patent/US20190328831A1/en not_active Abandoned
- 2019-08-28 JP JP2019155678A patent/JP6989571B2/ja active Active
-
2021
- 2021-06-21 JP JP2021102221A patent/JP7346494B2/ja active Active
-
2022
- 2022-09-14 JP JP2022146052A patent/JP2022171795A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP6989571B2 (ja) | 2022-01-05 |
| JP2021155433A (ja) | 2021-10-07 |
| DK3209317T3 (da) | 2022-02-07 |
| US20190328831A1 (en) | 2019-10-31 |
| EP3209317B1 (en) | 2021-12-08 |
| US20160113994A1 (en) | 2016-04-28 |
| CN114028536B (zh) | 2024-07-09 |
| SI3209317T1 (sl) | 2022-05-31 |
| US10335452B2 (en) | 2019-07-02 |
| ES2904492T3 (es) | 2022-04-05 |
| JP2017534618A (ja) | 2017-11-24 |
| JP2022171795A (ja) | 2022-11-11 |
| CN107206049A (zh) | 2017-09-26 |
| JP7346494B2 (ja) | 2023-09-19 |
| AU2015335855A1 (en) | 2017-05-18 |
| FI3978074T3 (fi) | 2024-05-20 |
| CN114028536A (zh) | 2022-02-11 |
| CN107206049B (zh) | 2021-12-07 |
| JP2019199485A (ja) | 2019-11-21 |
| WO2016065117A1 (en) | 2016-04-28 |
| EP3209317A1 (en) | 2017-08-30 |
| DK3978074T3 (da) | 2024-05-13 |
| EP3981420A1 (en) | 2022-04-13 |
| EP3978074B1 (en) | 2024-03-06 |
| HUE058066T2 (hu) | 2022-06-28 |
| HRP20220225T1 (hr) | 2022-04-29 |
| JP6673915B2 (ja) | 2020-03-25 |
| EP3978074A1 (en) | 2022-04-06 |
| PL3209317T3 (pl) | 2022-05-23 |
| ES2987577T3 (es) | 2024-11-15 |
| PT3209317T (pt) | 2022-01-19 |
| PL3978074T3 (pl) | 2024-08-12 |
| PT3978074T (pt) | 2024-05-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10335452B2 (en) | Method of treating patients with hepatorenal syndrome type 1 | |
| US20240374675A1 (en) | Method of treating patients with hepatorenal syndrome type 1 | |
| US20220143132A1 (en) | Method of treating patients with hepatorenal syndrome type 1 | |
| US20250276033A1 (en) | Compositions for improving kidney function in patients with hepatorenal syndrome | |
| US20200237856A1 (en) | Method of treating patients with hepatorenal syndrome type 1 | |
| US20210128676A1 (en) | Method of treating patients with hepatorenal syndrome type 1 and low mean arterial pressure | |
| AU2022288996A9 (en) | Method of treating patients with hepatorenal syndrome type 1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20220112 |
|
| FZDE | Discontinued |
Effective date: 20220112 |
|
| FZDE | Discontinued |
Effective date: 20220112 |