CA2951881C - Treatment of virus-based diseases of the skin - Google Patents
Treatment of virus-based diseases of the skin Download PDFInfo
- Publication number
- CA2951881C CA2951881C CA2951881A CA2951881A CA2951881C CA 2951881 C CA2951881 C CA 2951881C CA 2951881 A CA2951881 A CA 2951881A CA 2951881 A CA2951881 A CA 2951881A CA 2951881 C CA2951881 C CA 2951881C
- Authority
- CA
- Canada
- Prior art keywords
- oil
- extract
- dandelion
- alcohol
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241000700605 Viruses Species 0.000 title abstract description 31
- 201000010099 disease Diseases 0.000 title abstract description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract description 15
- 238000011282 treatment Methods 0.000 title abstract description 14
- 239000000284 extract Substances 0.000 claims abstract description 38
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 32
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 32
- 241000245665 Taraxacum Species 0.000 claims abstract description 31
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims abstract description 19
- 208000007514 Herpes zoster Diseases 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 239000003921 oil Substances 0.000 claims description 8
- 235000019198 oils Nutrition 0.000 claims description 8
- 235000019489 Almond oil Nutrition 0.000 claims description 6
- 235000019501 Lemon oil Nutrition 0.000 claims description 6
- 235000003434 Sesamum indicum Nutrition 0.000 claims description 6
- 244000000231 Sesamum indicum Species 0.000 claims description 6
- 235000019486 Sunflower oil Nutrition 0.000 claims description 6
- 239000008168 almond oil Substances 0.000 claims description 6
- 239000003240 coconut oil Substances 0.000 claims description 6
- 235000019864 coconut oil Nutrition 0.000 claims description 6
- -1 jojoba oil Substances 0.000 claims description 6
- 229940119170 jojoba wax Drugs 0.000 claims description 6
- 239000010501 lemon oil Substances 0.000 claims description 6
- 239000000944 linseed oil Substances 0.000 claims description 6
- 235000021388 linseed oil Nutrition 0.000 claims description 6
- 239000004006 olive oil Substances 0.000 claims description 6
- 235000008390 olive oil Nutrition 0.000 claims description 6
- 239000002600 sunflower oil Substances 0.000 claims description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 15
- 238000000034 method Methods 0.000 abstract description 4
- 239000010773 plant oil Substances 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 12
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 11
- 210000003491 skin Anatomy 0.000 description 11
- 239000002544 virustatic Substances 0.000 description 11
- 230000001790 virustatic effect Effects 0.000 description 11
- 241001529453 unidentified herpesvirus Species 0.000 description 10
- 239000004480 active ingredient Substances 0.000 description 8
- 206010067152 Oral herpes Diseases 0.000 description 7
- 241000701074 Human alphaherpesvirus 2 Species 0.000 description 6
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 210000002569 neuron Anatomy 0.000 description 6
- 239000002777 nucleoside Substances 0.000 description 6
- 230000010076 replication Effects 0.000 description 6
- 230000004913 activation Effects 0.000 description 5
- 230000003612 virological effect Effects 0.000 description 5
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 125000003835 nucleoside group Chemical group 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 108020005202 Viral DNA Proteins 0.000 description 3
- 229960004150 aciclovir Drugs 0.000 description 3
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 3
- 230000000840 anti-viral effect Effects 0.000 description 3
- 230000000120 cytopathologic effect Effects 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000001294 liquid chromatography-tandem mass spectrometry Methods 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 150000003833 nucleoside derivatives Chemical class 0.000 description 3
- 210000004927 skin cell Anatomy 0.000 description 3
- 238000007910 systemic administration Methods 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000283073 Equus caballus Species 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241000282898 Sus scrofa Species 0.000 description 2
- 241000292546 Taraxacum mongolicum Species 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 210000003050 axon Anatomy 0.000 description 2
- 210000003855 cell nucleus Anatomy 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000001320 lysogenic effect Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000011200 topical administration Methods 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 241000680578 Canid alphaherpesvirus 1 Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 201000006082 Chickenpox Diseases 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 208000037952 HSV-1 infection Diseases 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000158526 Nasalis Species 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 240000001949 Taraxacum officinale Species 0.000 description 1
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 description 1
- 206010046980 Varicella Diseases 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 108700005077 Viral Genes Proteins 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000006472 autoimmune response Effects 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 235000020691 dandelion extract Nutrition 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 210000000256 facial nerve Anatomy 0.000 description 1
- 229960005102 foscarnet Drugs 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 201000004946 genital herpes Diseases 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 235000021384 green leafy vegetables Nutrition 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000015788 innate immune response Effects 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 201000010666 keratoconjunctivitis Diseases 0.000 description 1
- 208000037954 latent HSV-1 infection Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003550 mucous cell Anatomy 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 238000004885 tandem mass spectrometry Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229940093257 valacyclovir Drugs 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 230000005727 virus proliferation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462010860P | 2014-06-11 | 2014-06-11 | |
| US62/010,860 | 2014-06-11 | ||
| PCT/US2015/035384 WO2015191891A1 (en) | 2014-06-11 | 2015-06-11 | Treatment of virus-based diseases of the skin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2951881A1 CA2951881A1 (en) | 2015-12-17 |
| CA2951881C true CA2951881C (en) | 2020-12-29 |
Family
ID=54834337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2951881A Active CA2951881C (en) | 2014-06-11 | 2015-06-11 | Treatment of virus-based diseases of the skin |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10034908B2 (enExample) |
| EP (1) | EP3154637A4 (enExample) |
| JP (1) | JP2017517543A (enExample) |
| CN (1) | CN106457000A (enExample) |
| CA (1) | CA2951881C (enExample) |
| WO (1) | WO2015191891A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3018294A1 (en) * | 2016-06-01 | 2017-12-07 | Excision Biotherapeutics, Inc. | Compositions and methods of treatment for lytic and lysogenic viruses |
| CN107184886B (zh) | 2017-05-16 | 2018-06-19 | 贾洪章 | 抗病毒中药组合物及其制备方法和用途 |
| US11065289B1 (en) | 2020-12-21 | 2021-07-20 | Elena Sanchez Alonso | Substance and method for the treatment of poxvirus |
| US12485153B1 (en) | 2021-06-16 | 2025-12-02 | Elena Sanchez Alonso | Substance for the treatment of poxvirus |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11103832A (ja) * | 1997-09-25 | 1999-04-20 | Sho Ki | タンポポ茶葉の製造方法、タンポポ茶葉、抗ウイルス剤 |
| CN1246029C (zh) | 2002-05-28 | 2006-03-22 | 杨毓龙 | 治疗带状疱疹的药物 |
| CN100998657A (zh) * | 2006-12-28 | 2007-07-18 | 江蕾 | 一种治疗带状疱疹的内服中药 |
| CN101023972A (zh) | 2007-03-26 | 2007-08-29 | 赵昱 | 蒲公英中酚酸类有效部位治疗口腔溃疡的用途 |
| CN101181366B (zh) * | 2007-11-26 | 2010-06-16 | 仲海崑 | 一种内服加外用治疗带状疱疹的中药组合物 |
| CN101391044A (zh) * | 2008-11-13 | 2009-03-25 | 牛德兴 | 一种治疗带状疱疹、单纯疱疹等病毒性疾病的外用中药及其制备方法 |
| US8609156B2 (en) * | 2009-10-05 | 2013-12-17 | Protanza Corporation | Compositions and methods of treatment that include plant extracts |
| CN102068611B (zh) * | 2009-11-19 | 2012-06-06 | 谢菊荣 | 一种治疗缠腰蛇的外用膏 |
| CN102961521B (zh) * | 2012-12-11 | 2014-06-11 | 王正艳 | 一种治疗单纯疱疹病毒性角膜炎的药物 |
| CN103800485B (zh) | 2014-03-12 | 2015-12-30 | 周比冠 | 一种治疗单纯疱疹病毒性角膜炎的中药制剂 |
-
2015
- 2015-06-11 CN CN201580029943.XA patent/CN106457000A/zh active Pending
- 2015-06-11 EP EP15807542.4A patent/EP3154637A4/en not_active Withdrawn
- 2015-06-11 CA CA2951881A patent/CA2951881C/en active Active
- 2015-06-11 JP JP2016572431A patent/JP2017517543A/ja active Pending
- 2015-06-11 WO PCT/US2015/035384 patent/WO2015191891A1/en not_active Ceased
- 2015-06-11 US US14/737,164 patent/US10034908B2/en active Active
-
2018
- 2018-06-22 US US16/015,701 patent/US10213468B2/en active Active
- 2018-06-22 US US16/015,711 patent/US10220066B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2951881A1 (en) | 2015-12-17 |
| EP3154637A1 (en) | 2017-04-19 |
| US20150359833A1 (en) | 2015-12-17 |
| CN106457000A (zh) | 2017-02-22 |
| JP2017517543A (ja) | 2017-06-29 |
| US10213468B2 (en) | 2019-02-26 |
| US10034908B2 (en) | 2018-07-31 |
| US10220066B2 (en) | 2019-03-05 |
| WO2015191891A1 (en) | 2015-12-17 |
| EP3154637A4 (en) | 2018-02-07 |
| US20180296619A1 (en) | 2018-10-18 |
| US20180296620A1 (en) | 2018-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20200610 |