CA2951497C - Imidazopyridazine derivatives as modulators of the gabaa receptor activity - Google Patents

Imidazopyridazine derivatives as modulators of the gabaa receptor activity Download PDF

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Publication number
CA2951497C
CA2951497C CA2951497A CA2951497A CA2951497C CA 2951497 C CA2951497 C CA 2951497C CA 2951497 A CA2951497 A CA 2951497A CA 2951497 A CA2951497 A CA 2951497A CA 2951497 C CA2951497 C CA 2951497C
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CA
Canada
Prior art keywords
compounds
formula
mmol
preparation
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2951497A
Other languages
English (en)
French (fr)
Other versions
CA2951497A1 (en
Inventor
Robert Mckenzie Owen
David Cameron Pryde
Mifune TAKEUCHI
Christine Anne Louise Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of CA2951497A1 publication Critical patent/CA2951497A1/en
Application granted granted Critical
Publication of CA2951497C publication Critical patent/CA2951497C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2951497A 2014-06-12 2015-06-03 Imidazopyridazine derivatives as modulators of the gabaa receptor activity Expired - Fee Related CA2951497C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462011137P 2014-06-12 2014-06-12
US62/011,137 2014-06-12
PCT/IB2015/054200 WO2015189744A1 (en) 2014-06-12 2015-06-03 Imidazopyridazine derivatives as modulators of the gabaa receptor activity.

Publications (2)

Publication Number Publication Date
CA2951497A1 CA2951497A1 (en) 2015-12-17
CA2951497C true CA2951497C (en) 2019-04-09

Family

ID=53434408

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2951497A Expired - Fee Related CA2951497C (en) 2014-06-12 2015-06-03 Imidazopyridazine derivatives as modulators of the gabaa receptor activity

Country Status (6)

Country Link
US (1) US9802945B2 (US07585860-20090908-C00112.png)
EP (1) EP3154979B1 (US07585860-20090908-C00112.png)
JP (1) JP6491679B2 (US07585860-20090908-C00112.png)
CA (1) CA2951497C (US07585860-20090908-C00112.png)
ES (1) ES2664810T3 (US07585860-20090908-C00112.png)
WO (1) WO2015189744A1 (US07585860-20090908-C00112.png)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3324961A4 (en) 2015-07-17 2019-03-13 Ovid Therapeutics, Inc. METHOD FOR TREATING DEVELOPMENT DISORDERS WITH GABOXADOL
EP3386983A1 (en) 2015-12-10 2018-10-17 Pfizer Limited 4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazine derivatives of formula (i) as gaba receptor modulators for use in the treatment of epilepsy and pain
WO2018003691A1 (ja) * 2016-06-28 2018-01-04 東レ株式会社 エポキシ樹脂組成物、プリプレグおよび繊維強化複合材料
EP3481387A4 (en) * 2016-08-11 2020-04-08 Ovid Therapeutics Inc METHOD AND COMPOSITIONS FOR TREATING EPILEPTIC DISEASES
US10071083B2 (en) 2017-02-03 2018-09-11 Ovid Therapeutics Inc Use of gaboxadol in the treatment of tinnitus
JP2020529440A (ja) 2017-08-04 2020-10-08 オービッド・セラピューティクス・インコーポレイテッドＯｖｉｄ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 糖尿病および関連する状態の処置におけるガボキサドールの使用
EP3982937A4 (en) * 2019-07-15 2022-08-10 Ovid Therapeutics Inc. PHARMACEUTICAL FORMULATIONS WITH GABOXADOL FOR THERAPEUTIC TREATMENT
US20220387429A1 (en) * 2019-10-21 2022-12-08 Sk Biopharmaceuticals Co., Ltd. Use of imidazopyrimidine or imidazotriazine compound for prevention, alleviation, or treatment of developmental disability
CN114981266A (zh) * 2019-10-22 2022-08-30 纽罗塞克医疗公司 Gabaa正向变构调节剂化合物、其制备方法和用途
WO2021081357A1 (en) * 2019-10-23 2021-04-29 Neurocycle Therapeutics, Inc. Treatment of epileptic conditions with gabaa receptor modulators
CN116693555A (zh) * 2022-02-25 2023-09-05 上海赛默罗生物科技有限公司 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途
WO2023213198A1 (zh) * 2022-05-04 2023-11-09 华东师范大学 芳香稠环化合物作为trek-1激活剂的用途、包含其的药物组合物、镇痛剂
CN117069725A (zh) * 2022-05-10 2023-11-17 上海赛默罗生物科技有限公司 咪唑并哒嗪取代苯环类衍生物、制备方法、药物组合物及用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
GB9921150D0 (en) * 1999-09-07 1999-11-10 Merck Sharp & Dohme Therapeutic agents
AU1253002A (en) 2000-11-10 2002-05-21 Merck Sharp & Dohme Imidazo-triazine derivatives as ligands for gaba receptors
GB0117277D0 (en) 2001-07-16 2001-09-05 Merck Sharp & Dohme Therapeutic agents
EP1838152A2 (en) * 2005-01-21 2007-10-03 Neurogen Corporation Imidazolylmethyl and pyrazolylmethyl heteroaryl derivatives
EP1995241B1 (en) 2007-03-23 2010-03-17 ICAgen, Inc. Inhibitors of ion channels
RS53941B1 (en) 2009-01-12 2015-08-31 Pfizer Limited SULFONAMID DERIVATIVES
SG175090A1 (en) 2009-05-07 2011-11-28 Astrazeneca Ab Substituted 1-cyanoethylheterocyclylcarboxamide compounds 750
UA112028C2 (uk) * 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора

Also Published As

Publication number Publication date
US9802945B2 (en) 2017-10-31
JP6491679B2 (ja) 2019-03-27
EP3154979A1 (en) 2017-04-19
WO2015189744A1 (en) 2015-12-17
CA2951497A1 (en) 2015-12-17
EP3154979B1 (en) 2018-03-07
JP2017517538A (ja) 2017-06-29
US20170197965A1 (en) 2017-07-13
ES2664810T3 (es) 2018-04-23

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EEER Examination request

Effective date: 20161207

MKLA Lapsed

Effective date: 20210603