CA2950088A1 - Heterobifunctional compounds having a triazole linker and e and/or p selectin binding affinity - Google Patents
Heterobifunctional compounds having a triazole linker and e and/or p selectin binding affinity Download PDFInfo
- Publication number
- CA2950088A1 CA2950088A1 CA2950088A CA2950088A CA2950088A1 CA 2950088 A1 CA2950088 A1 CA 2950088A1 CA 2950088 A CA2950088 A CA 2950088A CA 2950088 A CA2950088 A CA 2950088A CA 2950088 A1 CA2950088 A1 CA 2950088A1
- Authority
- CA
- Canada
- Prior art keywords
- chosen
- groups
- compound
- alkyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562262155P | 2015-12-02 | 2015-12-02 | |
| US62/262,155 | 2015-12-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2950088A1 true CA2950088A1 (en) | 2017-06-02 |
Family
ID=57681725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2950088A Abandoned CA2950088A1 (en) | 2015-12-02 | 2016-11-30 | Heterobifunctional compounds having a triazole linker and e and/or p selectin binding affinity |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20200171005A9 (enExample) |
| EP (1) | EP3383882A1 (enExample) |
| JP (1) | JP2019501130A (enExample) |
| CA (1) | CA2950088A1 (enExample) |
| WO (1) | WO2017095904A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10519181B2 (en) | 2014-12-03 | 2019-12-31 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| JP2019524791A (ja) | 2016-08-08 | 2019-09-05 | グリコミメティクス， インコーポレイテッド | Ｅ−セレクチンの阻害剤もしくはｃｘｃｒ４の阻害剤との、またはｅ−セレクチンおよびｃｘｃｒ４両方のヘテロ二機能性阻害剤とのｔ細胞チェックポイント阻害剤の組み合わせ |
| CN117298287A (zh) | 2016-10-07 | 2023-12-29 | 糖模拟物有限公司 | 高效的多聚体e-选择蛋白拮抗剂 |
| WO2018169853A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| JP7275131B2 (ja) | 2017-11-30 | 2023-05-17 | グリコミメティクス， インコーポレイテッド | 骨髄浸潤リンパ球を動員する方法、およびその使用 |
| WO2019133878A1 (en) * | 2017-12-29 | 2019-07-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
| WO2019173229A1 (en) | 2018-03-05 | 2019-09-12 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| US20220220144A1 (en) * | 2019-04-24 | 2022-07-14 | Glycomimetics, Inc. | Multimeric pan-selectin antagonists |
| AU2020334987A1 (en) * | 2019-08-20 | 2022-03-31 | Glycomimetics, Inc. | Process for preparing an E-selectin inhibitor intermediate |
| WO2021195465A1 (en) | 2020-03-27 | 2021-09-30 | Magnani John L | Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin |
| JP2023527411A (ja) | 2020-05-31 | 2023-06-28 | グリコミメティクス， インコーポレイテッド | がん細胞の負荷を減少させ、正常な造血を保護するための化合物および方法 |
| AU2021292458A1 (en) | 2020-06-14 | 2023-01-19 | GlycoMimetics | Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting |
| US20240269157A1 (en) | 2021-08-03 | 2024-08-15 | Glycomimetics, Inc. | Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006515306A (ja) * | 2002-12-20 | 2006-05-25 | グリコミメティクス， インコーポレイテッド | Ｐｓｅｕｄｏｍｏｎａｓ細菌感染の処置のためのオリゴ糖およびその結合体 |
| US7728117B2 (en) * | 2005-09-02 | 2010-06-01 | Glycomimetics, Inc. | Heterobifunctional pan-selectin inhibitors |
| WO2009126556A1 (en) * | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| US8921328B2 (en) * | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
-
2016
- 2016-11-30 JP JP2018526565A patent/JP2019501130A/ja active Pending
- 2016-11-30 US US15/781,072 patent/US20200171005A9/en not_active Abandoned
- 2016-11-30 WO PCT/US2016/064189 patent/WO2017095904A1/en not_active Ceased
- 2016-11-30 EP EP16820045.9A patent/EP3383882A1/en not_active Withdrawn
- 2016-11-30 CA CA2950088A patent/CA2950088A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20180369205A1 (en) | 2018-12-27 |
| EP3383882A1 (en) | 2018-10-10 |
| US20200171005A9 (en) | 2020-06-04 |
| WO2017095904A1 (en) | 2017-06-08 |
| JP2019501130A (ja) | 2019-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20230221 |
|
| FZDE | Discontinued |
Effective date: 20230221 |