CA2949754A1 - Use of aminoglycoside analogs in the treatment of rett syndrome - Google Patents
Use of aminoglycoside analogs in the treatment of rett syndrome Download PDFInfo
- Publication number
- CA2949754A1 CA2949754A1 CA2949754A CA2949754A CA2949754A1 CA 2949754 A1 CA2949754 A1 CA 2949754A1 CA 2949754 A CA2949754 A CA 2949754A CA 2949754 A CA2949754 A CA 2949754A CA 2949754 A1 CA2949754 A1 CA 2949754A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- alkyl
- mecp2
- rett syndrome
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462008028P | 2014-06-05 | 2014-06-05 | |
| US62/008,028 | 2014-06-05 | ||
| PCT/IL2015/050573 WO2015186134A1 (en) | 2014-06-05 | 2015-06-04 | Use of aminoglycoside analogs in the treatment of rett syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2949754A1 true CA2949754A1 (en) | 2015-12-10 |
Family
ID=53525222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2949754A Abandoned CA2949754A1 (en) | 2014-06-05 | 2015-06-04 | Use of aminoglycoside analogs in the treatment of rett syndrome |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20170360817A1 (OSRAM) |
| EP (1) | EP3151840A1 (OSRAM) |
| JP (1) | JP2017516835A (OSRAM) |
| CA (1) | CA2949754A1 (OSRAM) |
| IL (1) | IL249402A0 (OSRAM) |
| WO (1) | WO2015186134A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS56739B1 (sr) | 2010-11-18 | 2018-03-30 | Technion Res & Dev Foundation | Aminoglikozidi i njihova upotreba u tretiranju genetskih poremećaja |
| EP3151840A1 (en) | 2014-06-05 | 2017-04-12 | Eloxx Pharmaceuticals Ltd. | Use of aminoglycoside analogs in the treatment of rett syndrome |
| WO2017037718A1 (en) | 2015-09-02 | 2017-03-09 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| US10899785B2 (en) * | 2015-09-02 | 2021-01-26 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| WO2017037717A1 (en) | 2015-09-02 | 2017-03-09 | Eloxx Pharmaceuticals Ltd. | Aminoglycoside derivatives and uses thereof in treating genetic disorders |
| US11136345B2 (en) * | 2017-03-15 | 2021-10-05 | Eloxx Pharmaceuticals Ltd. | Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5960712A (ja) | 1982-09-30 | 1984-04-06 | Toshiba Corp | デ−タ判別装置 |
| WO2005078099A1 (en) * | 2004-02-17 | 2005-08-25 | The Hospital For Sick Children | Mecp2e1 gene |
| EP3421481A1 (en) | 2006-04-03 | 2019-01-02 | Technion Research and Development Foundation Ltd. | Novel aminoglycosides and uses thereof in the treatment of genetic disorders |
| RS56739B1 (sr) | 2010-11-18 | 2018-03-30 | Technion Res & Dev Foundation | Aminoglikozidi i njihova upotreba u tretiranju genetskih poremećaja |
| EP3151840A1 (en) | 2014-06-05 | 2017-04-12 | Eloxx Pharmaceuticals Ltd. | Use of aminoglycoside analogs in the treatment of rett syndrome |
-
2015
- 2015-06-04 EP EP15735743.5A patent/EP3151840A1/en not_active Withdrawn
- 2015-06-04 CA CA2949754A patent/CA2949754A1/en not_active Abandoned
- 2015-06-04 JP JP2016571284A patent/JP2017516835A/ja active Pending
- 2015-06-04 US US15/316,209 patent/US20170360817A1/en not_active Abandoned
- 2015-06-04 WO PCT/IL2015/050573 patent/WO2015186134A1/en not_active Ceased
-
2016
- 2016-12-05 IL IL249402A patent/IL249402A0/en unknown
-
2019
- 2019-01-28 US US16/258,735 patent/US10576095B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10576095B2 (en) | 2020-03-03 |
| JP2017516835A (ja) | 2017-06-22 |
| US20190183915A1 (en) | 2019-06-20 |
| US20170360817A1 (en) | 2017-12-21 |
| EP3151840A1 (en) | 2017-04-12 |
| IL249402A0 (en) | 2017-02-28 |
| WO2015186134A1 (en) | 2015-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20211123 |
|
| FZDE | Discontinued |
Effective date: 20211123 |