CA2949405C - Novel specific-binding polypeptides and uses thereof - Google Patents

Novel specific-binding polypeptides and uses thereof Download PDF

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Publication number
CA2949405C
CA2949405C CA2949405A CA2949405A CA2949405C CA 2949405 C CA2949405 C CA 2949405C CA 2949405 A CA2949405 A CA 2949405A CA 2949405 A CA2949405 A CA 2949405A CA 2949405 C CA2949405 C CA 2949405C
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Prior art keywords
mutein
seq
lipocalin
binding
fusion protein
Prior art date
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CA2949405A
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English (en)
French (fr)
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CA2949405A1 (en
Inventor
Marlon HINNER
Alexander WIEDENMANN
Andrea ALLERSDORFER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pieris Pharmaceuticals GmbH
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Pieris Pharmaceuticals GmbH
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Priority to CA3170782A priority Critical patent/CA3170782A1/en
Publication of CA2949405A1 publication Critical patent/CA2949405A1/en
Application granted granted Critical
Publication of CA2949405C publication Critical patent/CA2949405C/en
Active legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/525—Tumor necrosis factor [TNF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • General Engineering & Computer Science (AREA)
CA2949405A 2014-05-22 2015-05-20 Novel specific-binding polypeptides and uses thereof Active CA2949405C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3170782A CA3170782A1 (en) 2014-05-22 2015-05-20 Novel specific-binding polypeptides and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14169488.5 2014-05-22
EP14169488 2014-05-22
PCT/EP2015/061034 WO2015177175A2 (en) 2014-05-22 2015-05-20 Novel specific-binding polypeptides and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3170782A Division CA3170782A1 (en) 2014-05-22 2015-05-20 Novel specific-binding polypeptides and uses thereof

Publications (2)

Publication Number Publication Date
CA2949405A1 CA2949405A1 (en) 2015-11-26
CA2949405C true CA2949405C (en) 2023-08-01

Family

ID=50771150

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2949405A Active CA2949405C (en) 2014-05-22 2015-05-20 Novel specific-binding polypeptides and uses thereof
CA3170782A Pending CA3170782A1 (en) 2014-05-22 2015-05-20 Novel specific-binding polypeptides and uses thereof

Family Applications After (1)

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CA3170782A Pending CA3170782A1 (en) 2014-05-22 2015-05-20 Novel specific-binding polypeptides and uses thereof

Country Status (14)

Country Link
US (2) US10774119B2 (https=)
EP (2) EP3145945B1 (https=)
JP (2) JP6753784B2 (https=)
KR (1) KR20170004011A (https=)
CN (2) CN113621050A (https=)
AU (2) AU2015261968B2 (https=)
BR (1) BR112016027024A2 (https=)
CA (2) CA2949405C (https=)
DK (1) DK3145945T3 (https=)
ES (1) ES2823563T3 (https=)
MX (2) MX384363B (https=)
RU (1) RU2723034C2 (https=)
SG (2) SG11201609274SA (https=)
WO (1) WO2015177175A2 (https=)

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CN109096374B (zh) * 2018-09-27 2022-11-18 深圳乐土沃森精准医疗有限公司 一种抑制肺癌转移的合成寡肽
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EP4146273A4 (en) * 2020-05-05 2024-07-31 Janssen Biotech, Inc. METHODS OF TREATING CROHN'S DISEASE USING A SPECIFIC ANTI-IL23 ANTIBODY
CN114805546B (zh) * 2022-06-08 2024-05-28 宁波市健康口腔医学研究院 一种检测口腔癌的t细胞表位多肽及其应用
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Publication number Publication date
ES2823563T3 (es) 2021-05-07
MX2016015235A (es) 2017-06-29
AU2019201007A1 (en) 2019-03-07
KR20170004011A (ko) 2017-01-10
WO2015177175A3 (en) 2016-02-18
US20170107266A1 (en) 2017-04-20
MX384363B (es) 2025-03-14
CN113621050A (zh) 2021-11-09
RU2016149596A3 (https=) 2019-01-22
DK3145945T3 (da) 2020-09-28
AU2019201007B2 (en) 2020-10-22
CN106573964B (zh) 2021-07-16
MX2021008318A (es) 2021-08-05
EP3789397A1 (en) 2021-03-10
EP3789397B1 (en) 2023-12-06
WO2015177175A2 (en) 2015-11-26
BR112016027024A2 (pt) 2017-10-31
EP3145945B1 (en) 2020-07-15
CN106573964A (zh) 2017-04-19
SG10201912019WA (en) 2020-02-27
CA2949405A1 (en) 2015-11-26
US20200377563A1 (en) 2020-12-03
SG11201609274SA (en) 2016-12-29
JP2017518748A (ja) 2017-07-13
JP2021035358A (ja) 2021-03-04
US10774119B2 (en) 2020-09-15
JP6753784B2 (ja) 2020-09-09
AU2015261968B2 (en) 2018-11-22
RU2016149596A (ru) 2018-06-26
AU2015261968A1 (en) 2016-11-24
RU2723034C2 (ru) 2020-06-08
CA3170782A1 (en) 2015-11-26
JP7084965B2 (ja) 2022-06-15
EP3145945A2 (en) 2017-03-29
US11345728B2 (en) 2022-05-31

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