CA2949213C - Low-power miniature led-based uv absorption detector with low detection limits for capillary liquid chromatography - Google Patents
Low-power miniature led-based uv absorption detector with low detection limits for capillary liquid chromatography Download PDFInfo
- Publication number
- CA2949213C CA2949213C CA2949213A CA2949213A CA2949213C CA 2949213 C CA2949213 C CA 2949213C CA 2949213 A CA2949213 A CA 2949213A CA 2949213 A CA2949213 A CA 2949213A CA 2949213 C CA2949213 C CA 2949213C
- Authority
- CA
- Canada
- Prior art keywords
- light
- capillary column
- detector
- led
- lens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000001514 detection method Methods 0.000 title claims abstract description 90
- 238000010521 absorption reaction Methods 0.000 title claims abstract description 29
- 238000003981 capillary liquid chromatography Methods 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 46
- 150000001875 compounds Chemical class 0.000 claims abstract description 21
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 238000009499 grossing Methods 0.000 claims description 38
- 238000001914 filtration Methods 0.000 claims description 11
- 230000035945 sensitivity Effects 0.000 claims description 9
- 238000012935 Averaging Methods 0.000 claims description 4
- 230000001364 causal effect Effects 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- 230000002829 reductive effect Effects 0.000 abstract description 17
- 238000004811 liquid chromatography Methods 0.000 description 23
- QIVBCDIJIAJPQS-UHFFFAOYSA-N tryptophan Chemical compound C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 12
- 238000010586 diagram Methods 0.000 description 11
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 8
- 238000002835 absorbance Methods 0.000 description 7
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 6
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 6
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 6
- 238000013461 design Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 6
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 6
- GGCZERPQGJTIQP-UHFFFAOYSA-M sodium 2-anthraquinonesulfonate Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)[O-])=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-M 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 230000001010 compromised effect Effects 0.000 description 5
- 239000005350 fused silica glass Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- 230000008030 elimination Effects 0.000 description 4
- 238000003379 elimination reaction Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 229910052710 silicon Inorganic materials 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 150000002989 phenols Chemical class 0.000 description 3
- 229940079877 pyrogallol Drugs 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229940035893 uracil Drugs 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 244000181917 Rubus leucodermis Species 0.000 description 2
- 235000011036 Rubus leucodermis Nutrition 0.000 description 2
- 235000003942 Rubus occidentalis Nutrition 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000000581 reactive spray deposition Methods 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/02—Mechanical
- G01N2201/022—Casings
- G01N2201/0221—Portable; cableless; compact; hand-held
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/062—LED's
- G01N2201/0621—Supply
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/069—Supply of sources
- G01N2201/0693—Battery powered circuitry
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461996803P | 2014-05-15 | 2014-05-15 | |
| US61/996,803 | 2014-05-15 | ||
| PCT/US2015/031023 WO2015175906A1 (en) | 2014-05-15 | 2015-05-15 | Low-power miniature led-based uv absorption detector with low detection limits for capillary liquid chromatography |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2949213A1 CA2949213A1 (en) | 2015-11-19 |
| CA2949213C true CA2949213C (en) | 2022-07-12 |
Family
ID=54480760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2949213A Active CA2949213C (en) | 2014-05-15 | 2015-05-15 | Low-power miniature led-based uv absorption detector with low detection limits for capillary liquid chromatography |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10060889B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3142765B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6804436B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106536011B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015259004B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2949213C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015175906A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2539504B (en) * | 2015-06-19 | 2019-04-17 | Aqua21 Ltd | Absorption Sensor for Measuring Substance Concentration |
| WO2017029712A1 (ja) * | 2015-08-18 | 2017-02-23 | 株式会社島津製作所 | 液体クロマトグラフ用検出器 |
| AT518576B1 (de) * | 2016-04-18 | 2018-07-15 | Scan Messtechnik Gmbh | Spektrometer |
| NL2019122A (en) | 2016-06-30 | 2018-01-09 | Asml Holding Nv | Adaptive filter for in-line correction |
| EP3589944A4 (en) * | 2017-03-03 | 2020-12-30 | Brigham Young University | MULTI-DETECTOR LIQUID CHROMATOGRAPHIC SYSTEM MULTIMODAL |
| EP3625545A1 (en) * | 2017-05-18 | 2020-03-25 | Brigham Young University | Combined fluorescence and absorption detector for on-column detection after capillary separation techniques |
| CN108562540A (zh) * | 2017-12-29 | 2018-09-21 | 深圳市华星光电技术有限公司 | 光学测试装置 |
| CN112219106B (zh) * | 2018-06-01 | 2024-04-09 | 水质监测有限公司 | 包括发射235nm光的UV-LED的便携式流动池检测器 |
| WO2020190969A1 (en) * | 2019-03-18 | 2020-09-24 | Life Technologies Corporation | Multi-capillary optical detection system |
| JP7235298B2 (ja) * | 2019-03-20 | 2023-03-08 | 株式会社日立ハイテクサイエンス | クロマトグラフのデータ処理装置、データ処理方法、およびクロマトグラフ |
| CN110047519B (zh) * | 2019-04-16 | 2021-08-24 | 广州大学 | 一种语音端点检测方法、装置及设备 |
| US12235201B2 (en) * | 2020-09-22 | 2025-02-25 | Becton, Dickinson And Company | Methods for continuous measurement of baseline noise in a flow cytometer and systems for same |
| CN115684446A (zh) * | 2022-09-28 | 2023-02-03 | 上海交通大学 | 等电聚焦毛细管结构、毛细管盒、全柱成像装置 |
| US20250321209A1 (en) * | 2024-04-16 | 2025-10-16 | Vuv Analytics, Inc. | Spectroscopy Systems, Flow Cells And Methods For Analyzing Liquids At Vacuum Ultraviolet (VUV) Wavelengths |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4927265A (en) * | 1988-04-29 | 1990-05-22 | 501 Microphoretic Systems, Inc. | Detector for fluorescence and absorption spectroscopy |
| US5124020A (en) * | 1989-09-26 | 1992-06-23 | Rutgers, The State University | Adjustable height and width aperture for capillary photodetector cell |
| JPH04115084U (ja) * | 1991-03-26 | 1992-10-12 | 九州電機製造株式会社 | 電気自動車用電池残存容量計 |
| US5235409A (en) * | 1991-08-13 | 1993-08-10 | Varian Associates, Inc. | Optical detection system for capillary separation columns |
| WO1993011422A1 (en) * | 1991-12-03 | 1993-06-10 | Applied Biosystems, Inc. | Capillary flowcell for multiple wavelength detection |
| DE69323060T2 (de) * | 1993-03-18 | 1999-06-10 | Novartis Ag, Basel | Optische Detektorvorrichtung für die chemische Analyse von kleinen fluiden Probenvolumina |
| US5533063A (en) * | 1994-01-31 | 1996-07-02 | The Regents Of The University Of California | Method and apparatus for multipath channel shaping |
| WO1997030347A1 (en) * | 1996-02-20 | 1997-08-21 | Waters Investments Limited | Capillary chromatography detector apparatus |
| US6788414B1 (en) | 1999-09-09 | 2004-09-07 | Iowa State University Research Foundation, Inc. | Method of analyzing multiple sample simultaneously by detecting absorption and systems for use in such a method |
| ATE522802T1 (de) * | 2001-01-26 | 2011-09-15 | Qiagen Sciences Llc | Mehrkanalkassette für biotrennung |
| US20030110840A1 (en) * | 2001-07-24 | 2003-06-19 | Arriaga Edgar A. | Systems and methods for detecting a particle |
| US7122799B2 (en) * | 2003-12-18 | 2006-10-17 | Palo Alto Research Center Incorporated | LED or laser enabled real-time PCR system and spectrophotometer |
| US20060019265A1 (en) * | 2004-04-30 | 2006-01-26 | Kimberly-Clark Worldwide, Inc. | Transmission-based luminescent detection systems |
| US7497937B2 (en) * | 2004-09-03 | 2009-03-03 | Combisep, Inc. | Microfabricated chip and method of use |
| CN1755351A (zh) * | 2004-09-30 | 2006-04-05 | 中国科学院大连化学物理研究所 | 发光二极管诱导荧光微型检测器 |
| GB0524225D0 (en) * | 2005-11-29 | 2006-01-04 | Amersham Biosciences Ab | Methods and apparatus for detecting and measuring the concentration of a substance in a solution |
| US8137626B2 (en) * | 2006-05-19 | 2012-03-20 | California Institute Of Technology | Fluorescence detector, filter device and related methods |
| US7846391B2 (en) | 2006-05-22 | 2010-12-07 | Lumencor, Inc. | Bioanalytical instrumentation using a light source subsystem |
| US8467059B2 (en) | 2006-10-27 | 2013-06-18 | University Of South Florida | Deep-UV LED and laser induced fluorescence detection and monitoring of trace organics in potable liquids |
| US7835000B2 (en) * | 2006-11-03 | 2010-11-16 | Los Alamos National Security, Llc | System and method for measuring particles in a sample stream of a flow cytometer or the like |
| US8098375B2 (en) | 2007-08-06 | 2012-01-17 | Lumencor, Inc. | Light emitting diode illumination system |
| JP2009080001A (ja) * | 2007-09-26 | 2009-04-16 | Fujitaro Imasaka | ガスクロマトグラフ質量分析法におけるデータ処理方法 |
| US20100324830A1 (en) | 2009-06-22 | 2010-12-23 | Solie John B | Handheld optical sensor for measuring the normalized difference vegetative index in plants |
| WO2013181362A1 (en) * | 2012-06-01 | 2013-12-05 | Advanced Analytical Technologies, Inc. | Multi-color detection system for multiplexed capillary electrophoresis |
| CN103529006B (zh) * | 2013-10-18 | 2016-08-17 | 大连海事大学 | 一种基于微流控芯片的便携式荧光检测装置 |
-
2015
- 2015-05-15 AU AU2015259004A patent/AU2015259004B2/en active Active
- 2015-05-15 CA CA2949213A patent/CA2949213C/en active Active
- 2015-05-15 CN CN201580038216.XA patent/CN106536011B/zh active Active
- 2015-05-15 US US14/713,328 patent/US10060889B2/en active Active
- 2015-05-15 JP JP2017512869A patent/JP6804436B2/ja active Active
- 2015-05-15 WO PCT/US2015/031023 patent/WO2015175906A1/en not_active Ceased
- 2015-05-15 EP EP15793306.0A patent/EP3142765B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3142765A1 (en) | 2017-03-22 |
| AU2015259004B2 (en) | 2018-11-08 |
| CN106536011A (zh) | 2017-03-22 |
| WO2015175906A1 (en) | 2015-11-19 |
| EP3142765B1 (en) | 2019-08-14 |
| JP6804436B2 (ja) | 2020-12-23 |
| CN106536011B (zh) | 2019-08-20 |
| US20150330955A1 (en) | 2015-11-19 |
| US10060889B2 (en) | 2018-08-28 |
| JP2017516120A (ja) | 2017-06-15 |
| AU2015259004A1 (en) | 2016-12-01 |
| CA2949213A1 (en) | 2015-11-19 |
| EP3142765A4 (en) | 2018-01-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20200513 |
|
| EEER | Examination request |
Effective date: 20200513 |