CA2947846C - Replacement heart valves and their methods of use and manufacture - Google Patents
Replacement heart valves and their methods of use and manufacture Download PDFInfo
- Publication number
- CA2947846C CA2947846C CA2947846A CA2947846A CA2947846C CA 2947846 C CA2947846 C CA 2947846C CA 2947846 A CA2947846 A CA 2947846A CA 2947846 A CA2947846 A CA 2947846A CA 2947846 C CA2947846 C CA 2947846C
- Authority
- CA
- Canada
- Prior art keywords
- support structure
- heart valve
- prosthetic heart
- leaflets
- leaflet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000003709 heart valve Anatomy 0.000 title claims description 197
- 238000000034 method Methods 0.000 title description 16
- 238000004519 manufacturing process Methods 0.000 title description 8
- 229920000642 polymer Polymers 0.000 claims abstract description 11
- 239000011248 coating agent Substances 0.000 claims abstract description 8
- 238000000576 coating method Methods 0.000 claims abstract description 8
- 239000008280 blood Substances 0.000 claims description 38
- 210000004369 blood Anatomy 0.000 claims description 38
- 230000017531 blood circulation Effects 0.000 claims description 25
- 239000000463 material Substances 0.000 claims description 25
- 238000005266 casting Methods 0.000 claims description 20
- 238000009958 sewing Methods 0.000 claims description 13
- 238000011144 upstream manufacturing Methods 0.000 claims description 13
- 230000007704 transition Effects 0.000 claims description 6
- 210000001765 aortic valve Anatomy 0.000 claims description 3
- 210000004115 mitral valve Anatomy 0.000 claims description 3
- 238000013459 approach Methods 0.000 description 8
- 230000006870 function Effects 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 6
- 230000033001 locomotion Effects 0.000 description 6
- 239000004696 Poly ether ether ketone Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 238000007598 dipping method Methods 0.000 description 5
- 229920002530 polyetherether ketone Polymers 0.000 description 5
- 229920002635 polyurethane Polymers 0.000 description 5
- 239000004814 polyurethane Substances 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 4
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- 206010067171 Regurgitation Diseases 0.000 description 2
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- 238000002513 implantation Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
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- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
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- 229920001601 polyetherimide Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 210000004763 bicuspid Anatomy 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000003698 laser cutting Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
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- 210000003102 pulmonary valve Anatomy 0.000 description 1
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- 230000002441 reversible effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
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- 210000000591 tricuspid valve Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0069—Three-dimensional shapes cylindrical
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3184797A CA3184797A1 (en) | 2014-05-09 | 2015-01-30 | Replacement heart valves and their methods of use and manufacture |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461991354P | 2014-05-09 | 2014-05-09 | |
| US61/991,354 | 2014-05-09 | ||
| PCT/US2015/013980 WO2015171190A1 (en) | 2014-05-09 | 2015-01-30 | Replacement heart valves and their methods of use and manufacture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3184797A Division CA3184797A1 (en) | 2014-05-09 | 2015-01-30 | Replacement heart valves and their methods of use and manufacture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2947846A1 CA2947846A1 (en) | 2015-11-12 |
| CA2947846C true CA2947846C (en) | 2023-03-14 |
Family
ID=54366809
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2947846A Active CA2947846C (en) | 2014-05-09 | 2015-01-30 | Replacement heart valves and their methods of use and manufacture |
| CA3184797A Pending CA3184797A1 (en) | 2014-05-09 | 2015-01-30 | Replacement heart valves and their methods of use and manufacture |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3184797A Pending CA3184797A1 (en) | 2014-05-09 | 2015-01-30 | Replacement heart valves and their methods of use and manufacture |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US9539089B2 (enExample) |
| EP (1) | EP3139866A4 (enExample) |
| JP (1) | JP6503454B2 (enExample) |
| CN (2) | CN107072783B (enExample) |
| AU (1) | AU2015256601B2 (enExample) |
| CA (2) | CA2947846C (enExample) |
| EA (1) | EA034896B1 (enExample) |
| WO (1) | WO2015171190A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2654624B1 (en) | 2010-12-23 | 2023-10-04 | Twelve, Inc. | System for mitral valve repair and replacement |
| EP4623867A3 (en) | 2011-06-21 | 2025-11-05 | Twelve, Inc. | Prosthetic heart valve devices |
| US9763780B2 (en) | 2011-10-19 | 2017-09-19 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
| US9039757B2 (en) | 2011-10-19 | 2015-05-26 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
| US9655722B2 (en) | 2011-10-19 | 2017-05-23 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
| US11202704B2 (en) | 2011-10-19 | 2021-12-21 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
| AU2012325809B2 (en) | 2011-10-19 | 2016-01-21 | Twelve, Inc. | Devices, systems and methods for heart valve replacement |
| AU2012325813A1 (en) | 2011-10-19 | 2014-04-03 | Twelve, Inc. | Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods |
| US9579198B2 (en) | 2012-03-01 | 2017-02-28 | Twelve, Inc. | Hydraulic delivery systems for prosthetic heart valve devices and associated methods |
| CN105246431B (zh) | 2013-05-20 | 2018-04-06 | 托尔福公司 | 可植入心脏瓣膜装置、二尖瓣修复装置以及相关系统和方法 |
| US9539089B2 (en) | 2014-05-09 | 2017-01-10 | Foldax, Inc. | Replacement heart valves and their methods of use and manufacture |
| US10507101B2 (en) | 2014-10-13 | 2019-12-17 | W. L. Gore & Associates, Inc. | Valved conduit |
| EP3337428B1 (en) | 2015-08-21 | 2024-09-25 | Twelve Inc. | Mitral valve repair devices |
| US10266657B2 (en) | 2015-10-29 | 2019-04-23 | Commonwealth Scientific And Industrial Research Organisation | Polyurethane/urea compositions |
| EP3448316B1 (en) | 2016-04-29 | 2023-03-29 | Medtronic Vascular Inc. | Prosthetic heart valve devices with tethered anchors |
| US10231833B2 (en) | 2016-10-28 | 2019-03-19 | Foldax, Inc. | Prosthetic heart valves with elastic support structures and related methods |
| US11351058B2 (en) | 2017-03-17 | 2022-06-07 | W. L. Gore & Associates, Inc. | Glaucoma treatment systems and methods |
| US10702378B2 (en) | 2017-04-18 | 2020-07-07 | Twelve, Inc. | Prosthetic heart valve device and associated systems and methods |
| US10575950B2 (en) | 2017-04-18 | 2020-03-03 | Twelve, Inc. | Hydraulic systems for delivering prosthetic heart valve devices and associated methods |
| US10433961B2 (en) | 2017-04-18 | 2019-10-08 | Twelve, Inc. | Delivery systems with tethers for prosthetic heart valve devices and associated methods |
| US10792151B2 (en) | 2017-05-11 | 2020-10-06 | Twelve, Inc. | Delivery systems for delivering prosthetic heart valve devices and associated methods |
| US10646338B2 (en) | 2017-06-02 | 2020-05-12 | Twelve, Inc. | Delivery systems with telescoping capsules for deploying prosthetic heart valve devices and associated methods |
| US10709591B2 (en) | 2017-06-06 | 2020-07-14 | Twelve, Inc. | Crimping device and method for loading stents and prosthetic heart valves |
| US12458491B2 (en) | 2017-06-30 | 2025-11-04 | Ohio State Innovation Foundation | Methods to improve the durability of polymeric heart valves |
| US10729541B2 (en) | 2017-07-06 | 2020-08-04 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
| US10786352B2 (en) | 2017-07-06 | 2020-09-29 | Twelve, Inc. | Prosthetic heart valve devices and associated systems and methods |
| CA3071667A1 (en) | 2017-08-04 | 2019-02-07 | Foldax, Inc. | Systems, devices, and methods relating to the manufacture of prosthetic valves |
| AU2018362080B2 (en) | 2017-10-31 | 2021-09-30 | Edwards Lifesciences Corporation | Valved conduit |
| JP7480944B2 (ja) * | 2017-12-11 | 2024-05-10 | カリフォルニア インスティテュート オブ テクノロジー | 血管内埋込可能補綴弁の製造に関するシステム、デバイス、および方法 |
| US11844914B2 (en) * | 2018-06-05 | 2023-12-19 | Edwards Lifesciences Corporation | Removable volume indicator for syringe |
| AU2019333136B2 (en) | 2018-08-29 | 2022-11-17 | W. L. Gore & Associates, Inc. | Drug therapy delivery systems and methods |
| USD977642S1 (en) | 2018-10-29 | 2023-02-07 | W. L. Gore & Associates, Inc. | Pulmonary valve conduit |
| US11678983B2 (en) | 2018-12-12 | 2023-06-20 | W. L. Gore & Associates, Inc. | Implantable component with socket |
| US12285331B2 (en) | 2019-03-18 | 2025-04-29 | Foldax, Inc. | Systems, devices, and methods relating to the manufacture of implantable prosthetic valves |
| WO2020233775A1 (en) | 2019-05-17 | 2020-11-26 | T-Heart SAS | Stent device for a prosthetic heart valve |
| US20220211904A1 (en) | 2021-01-06 | 2022-07-07 | The Secant Group, Llc | Poly(glycerol sebacate) urethane elastomeric leaflet for heart valve replacement |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4291420A (en) | 1973-11-09 | 1981-09-29 | Medac Gesellschaft Fur Klinische Spezialpraparate Mbh | Artificial heart valve |
| US3983581A (en) | 1975-01-20 | 1976-10-05 | William W. Angell | Heart valve stent |
| US4222126A (en) | 1978-12-14 | 1980-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare | Unitized three leaflet heart valve |
| US4265694A (en) | 1978-12-14 | 1981-05-05 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Method of making unitized three leaflet heart valve |
| US4364127A (en) | 1981-10-02 | 1982-12-21 | Research Corporation | Trileaflet type prosthetic heart valve |
| ATE21330T1 (de) | 1982-01-20 | 1986-08-15 | Martin Morris Black | Kuenstliche herzklappen. |
| US4473423A (en) | 1982-05-03 | 1984-09-25 | University Of Utah | Artificial heart valve made by vacuum forming technique |
| US4506394A (en) | 1983-01-13 | 1985-03-26 | Molrose Management, Ltd. | Cardiac valve prosthesis holder |
| CA1232407A (en) | 1983-06-23 | 1988-02-09 | David K. Walker | Bubble heart valve |
| US4556996A (en) | 1983-08-04 | 1985-12-10 | Robert S. Wallace | Heart valve |
| US4626255A (en) | 1983-09-23 | 1986-12-02 | Christian Weinhold | Heart valve bioprothesis |
| US4888009A (en) | 1985-04-05 | 1989-12-19 | Abiomed, Inc. | Prosthetic heart valve |
| DE3541478A1 (de) | 1985-11-23 | 1987-05-27 | Beiersdorf Ag | Herzklappenprothese und verfahren zu deren herstellung |
| DE3834545A1 (de) | 1988-10-11 | 1990-04-12 | Rau Guenter | Flexibles schliessorgan, insbesondere herzklappe, und verfahren zur herstellung desselben |
| US5037434A (en) * | 1990-04-11 | 1991-08-06 | Carbomedics, Inc. | Bioprosthetic heart valve with elastic commissures |
| US5147391A (en) | 1990-04-11 | 1992-09-15 | Carbomedics, Inc. | Bioprosthetic heart valve with semi-permeable commissure posts and deformable leaflets |
| US5163955A (en) * | 1991-01-24 | 1992-11-17 | Autogenics | Rapid assembly, concentric mating stent, tissue heart valve with enhanced clamping and tissue alignment |
| US5489298A (en) | 1991-01-24 | 1996-02-06 | Autogenics | Rapid assembly concentric mating stent, tissue heart valve with enhanced clamping and tissue exposure |
| SK279539B6 (sk) | 1991-05-08 | 1998-12-02 | Nika Health Products Limited | Rdcovej chlopne |
| IT1245750B (it) | 1991-05-24 | 1994-10-14 | Sorin Biomedica Emodialisi S R | Protesi valvolare cardiaca, particolarmente per sostituzione della valvola aortica |
| US5489297A (en) | 1992-01-27 | 1996-02-06 | Duran; Carlos M. G. | Bioprosthetic heart valve with absorbable stent |
| US5258023A (en) * | 1992-02-12 | 1993-11-02 | Reger Medical Development, Inc. | Prosthetic heart valve |
| GB9206449D0 (en) | 1992-03-25 | 1992-05-06 | Univ Leeds | Artificial heart valve |
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| US5861028A (en) | 1996-09-09 | 1999-01-19 | Shelhigh Inc | Natural tissue heart valve and stent prosthesis and method for making the same |
| NL1004827C2 (nl) | 1996-12-18 | 1998-06-19 | Surgical Innovations Vof | Inrichting voor het reguleren van de bloedsomloop. |
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| JP2002518131A (ja) | 1998-06-24 | 2002-06-25 | サルザー カーボメディクス インコーポレイテッド | 変化してリーフレット上の最大負荷圧力の位置および大きさに影響を及ぼす心臓弁リーフレット連結構造 |
| US6117169A (en) | 1998-06-24 | 2000-09-12 | Sulzer Carbomedics Inc. | Living hinge attachment of leaflet to a valve body |
| US6334873B1 (en) | 1998-09-28 | 2002-01-01 | Autogenics | Heart valve having tissue retention with anchors and an outer sheath |
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| US6283995B1 (en) | 1999-04-15 | 2001-09-04 | Sulzer Carbomedics Inc. | Heart valve leaflet with scalloped free margin |
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| US6478819B2 (en) | 1999-05-27 | 2002-11-12 | Sulzer Carbomedics Inc. | Prosthetic heart valves with flexible post geometry |
| US6174331B1 (en) | 1999-07-19 | 2001-01-16 | Sulzer Carbomedics Inc. | Heart valve leaflet with reinforced free margin |
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| US20030097175A1 (en) | 1999-12-08 | 2003-05-22 | O'connor Bernard | Heart valve prosthesis and method of manufacture |
| EP2329796B1 (en) | 2000-01-31 | 2021-09-01 | Cook Biotech Incorporated | Stent valve |
| US6454799B1 (en) | 2000-04-06 | 2002-09-24 | Edwards Lifesciences Corporation | Minimally-invasive heart valves and methods of use |
| DE10046550A1 (de) | 2000-09-19 | 2002-03-28 | Adiam Life Science Ag | Prothetische Mitral-Herzklappe |
| US6461382B1 (en) | 2000-09-22 | 2002-10-08 | Edwards Lifesciences Corporation | Flexible heart valve having moveable commissures |
| US6953332B1 (en) * | 2000-11-28 | 2005-10-11 | St. Jude Medical, Inc. | Mandrel for use in forming valved prostheses having polymer leaflets by dip coating |
| US6716244B2 (en) | 2000-12-20 | 2004-04-06 | Carbomedics, Inc. | Sewing cuff assembly for heart valves |
| US6596024B2 (en) | 2000-12-21 | 2003-07-22 | Carbomedics Inc. | Polymeric heart valve fabricated from polyurethane/polysiliconeurethane blends |
| US6454798B1 (en) | 2000-12-21 | 2002-09-24 | Sulzer Carbomedics Inc. | Polymer heart valve with helical coaption surface |
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-
2015
- 2015-01-30 US US14/611,071 patent/US9539089B2/en active Active
- 2015-01-30 CN CN201580037307.1A patent/CN107072783B/zh active Active
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- 2015-01-30 CA CA2947846A patent/CA2947846C/en active Active
- 2015-01-30 JP JP2017511144A patent/JP6503454B2/ja active Active
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| EP3139866A1 (en) | 2017-03-15 |
| EA201692273A1 (ru) | 2017-05-31 |
| CA3184797A1 (en) | 2015-11-12 |
| US20150320555A1 (en) | 2015-11-12 |
| CN107072783A (zh) | 2017-08-18 |
| AU2015256601B2 (en) | 2020-01-23 |
| CN112891028B (zh) | 2024-09-17 |
| CN112891028A (zh) | 2021-06-04 |
| CA2947846A1 (en) | 2015-11-12 |
| JP2017514664A (ja) | 2017-06-08 |
| US9301837B2 (en) | 2016-04-05 |
| US20210236275A1 (en) | 2021-08-05 |
| US20150320554A1 (en) | 2015-11-12 |
| US9539089B2 (en) | 2017-01-10 |
| JP6503454B2 (ja) | 2019-04-17 |
| WO2015171190A1 (en) | 2015-11-12 |
| US20240074850A1 (en) | 2024-03-07 |
| EP3139866A4 (en) | 2017-12-13 |
| EA034896B1 (ru) | 2020-04-03 |
| US11654019B2 (en) | 2023-05-23 |
| US10918477B2 (en) | 2021-02-16 |
| AU2015256601A1 (en) | 2016-11-17 |
| US20170079782A1 (en) | 2017-03-23 |
| CN107072783B (zh) | 2021-03-19 |
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