CA2947029A1 - Separation et analyse d'entites cibles a l'aide de membranes de filtration comprenant un materiau perfore a deux dimensions - Google Patents
Separation et analyse d'entites cibles a l'aide de membranes de filtration comprenant un materiau perfore a deux dimensions Download PDFInfo
- Publication number
- CA2947029A1 CA2947029A1 CA2947029A CA2947029A CA2947029A1 CA 2947029 A1 CA2947029 A1 CA 2947029A1 CA 2947029 A CA2947029 A CA 2947029A CA 2947029 A CA2947029 A CA 2947029A CA 2947029 A1 CA2947029 A1 CA 2947029A1
- Authority
- CA
- Canada
- Prior art keywords
- filter
- fluid
- membranes
- perforated
- membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 190
- 239000000463 material Substances 0.000 title claims abstract description 98
- 238000000926 separation method Methods 0.000 title claims description 44
- 238000003556 assay Methods 0.000 title description 36
- 238000001914 filtration Methods 0.000 title description 25
- 239000012530 fluid Substances 0.000 claims abstract description 121
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 102
- 229910021389 graphene Inorganic materials 0.000 claims abstract description 88
- 239000011148 porous material Substances 0.000 claims abstract description 75
- 238000000034 method Methods 0.000 claims abstract description 51
- 239000000126 substance Substances 0.000 claims abstract description 25
- 230000007423 decrease Effects 0.000 claims abstract description 13
- 238000012986 modification Methods 0.000 claims description 9
- 230000004048 modification Effects 0.000 claims description 9
- 231100000765 toxin Toxicity 0.000 claims description 7
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- 238000004458 analytical method Methods 0.000 description 28
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- 150000007523 nucleic acids Chemical class 0.000 description 8
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- 239000013078 crystal Substances 0.000 description 6
- 238000001514 detection method Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 108700012359 toxins Proteins 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 125000004429 atom Chemical group 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
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- 239000000203 mixture Substances 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 239000013060 biological fluid Substances 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 150000003384 small molecules Chemical class 0.000 description 4
- 230000004913 activation Effects 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000007398 colorimetric assay Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- -1 halide ions Chemical class 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- 150000004770 chalcogenides Chemical class 0.000 description 2
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- 238000010276 construction Methods 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
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- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 238000010339 medical test Methods 0.000 description 2
- CWQXQMHSOZUFJS-UHFFFAOYSA-N molybdenum disulfide Chemical compound S=[Mo]=S CWQXQMHSOZUFJS-UHFFFAOYSA-N 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 238000011045 prefiltration Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000007829 radioisotope assay Methods 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000010189 synthetic method Methods 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 229910052582 BN Inorganic materials 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 238000001327 Förster resonance energy transfer Methods 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003131 biological toxin Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 150000005829 chemical entities Chemical class 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000009295 crossflow filtration Methods 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
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- 238000009472 formulation Methods 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
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- 229910052742 iron Inorganic materials 0.000 description 1
- 238000000670 ligand binding assay Methods 0.000 description 1
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- 238000005259 measurement Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 239000002159 nanocrystal Substances 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 150000001282 organosilanes Chemical class 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
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- 239000010703 silicon Substances 0.000 description 1
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- 125000006850 spacer group Chemical group 0.000 description 1
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- 230000001954 sterilising effect Effects 0.000 description 1
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- 229910052717 sulfur Chemical group 0.000 description 1
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- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0272—Investigating particle size or size distribution with screening; with classification by filtering
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4088—Concentrating samples by other techniques involving separation of suspended solids filtration
Landscapes
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Selon l'invention, du graphène perforé et d'autres matériaux à deux dimensions perforés peuvent être utilisés pour isoler des entités cibles ayant une plage particulière de tailles ou de caractéristiques chimiques. Les entités cibles isolées sur celui-ci peuvent en outre être analysées à des fins de quantification/qualification. L'utilisation de plusieurs membranes de filtre peut permettre à des plages de tailles particulières ou des caractéristiques chimiques particulières d'entités cibles d'être isolées et en outre analysées. Des procédés d'analyse d'une entité cible, en particulier une entité cible biologique, peuvent comprendre la fourniture d'une ou plusieurs membranes de filtre disposés en série entre elles, les membranes de filtre contenant un matériau perforé à deux dimensions, et les membranes de filtre ayant une taille de pores effective qui diminue dans une direction d'écoulement de fluide prévue ; et le passage d'un fluide à travers les membranes de filtre. Les procédés peuvent également comprendre l'analyse d'au moins une entité cible sur les membranes de filtre.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461987410P | 2014-05-01 | 2014-05-01 | |
| US61/987,410 | 2014-05-01 | ||
| PCT/US2015/018114 WO2015131109A1 (fr) | 2014-02-28 | 2015-02-27 | Seringue pour obtenir des matières de taille submicronique pour des dosages sélectifs et procédés d'utilisation associés |
| USPCT/US2015/018114 | 2015-02-27 | ||
| PCT/US2015/028948 WO2015168653A1 (fr) | 2014-05-01 | 2015-05-01 | Séparation et analyse d'entités cibles à l'aide de membranes de filtration comprenant un matériau perforé à deux dimensions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2947029A1 true CA2947029A1 (fr) | 2015-11-05 |
Family
ID=54359410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2947029A Abandoned CA2947029A1 (fr) | 2014-05-01 | 2015-05-01 | Separation et analyse d'entites cibles a l'aide de membranes de filtration comprenant un materiau perfore a deux dimensions |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP3137188A4 (fr) |
| JP (1) | JP2017519974A (fr) |
| CN (1) | CN106457078A (fr) |
| AU (1) | AU2015252784A1 (fr) |
| CA (1) | CA2947029A1 (fr) |
| WO (1) | WO2015168653A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201701654UA (en) | 2014-09-02 | 2017-04-27 | Lockheed Corp | Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6699684B2 (en) * | 2002-07-23 | 2004-03-02 | Nalco Company | Method of monitoring biofouling in membrane separation systems |
| DE20302819U1 (de) * | 2003-02-21 | 2003-05-08 | Filtertek Sa | Filter für medizinische und Laborzwecke, insbesondere für Blutanalysen u.dgl. |
| JP2006262891A (ja) * | 2004-11-30 | 2006-10-05 | D M L:Kk | 液体試料中の微生物の測定キット及び測定方法及び測定装置 |
| US20060166347A1 (en) * | 2005-01-27 | 2006-07-27 | Applera Corporation | Sample preparation devices and methods |
| US20080045877A1 (en) * | 2006-08-15 | 2008-02-21 | G&L Consulting, Llc | Blood exchange dialysis method and apparatus |
| DE102008024106A1 (de) * | 2008-05-17 | 2009-11-19 | Heinrich, Hans-Werner, Prof. Dr. | Vorrichtung zum Abscheiden von Partikeln in und aus Flüssigkeiten und deren Anwendung in Biotechnologie, biologische Forschung, Diagnostik und Krankheitsbehandlung |
| FI122495B (fi) * | 2009-05-22 | 2012-02-29 | Teknologian Tutkimuskeskus Vtt | Näyteportti, monikerrossuodatin, näytteenottomenetelmä ja näyteportin käyttö näytteenotossa |
| IN2014DN08466A (fr) | 2012-03-15 | 2015-05-08 | Massachusetts Inst Technology | |
| US20130240355A1 (en) * | 2012-03-16 | 2013-09-19 | Lockheed Martin Corporation | Functionalization of graphene holes for deionization |
| US9095823B2 (en) * | 2012-03-29 | 2015-08-04 | Lockheed Martin Corporation | Tunable layered membrane configuration for filtration and selective isolation and recovery devices |
-
2015
- 2015-05-01 CN CN201580021974.0A patent/CN106457078A/zh active Pending
- 2015-05-01 EP EP15786691.4A patent/EP3137188A4/fr not_active Withdrawn
- 2015-05-01 CA CA2947029A patent/CA2947029A1/fr not_active Abandoned
- 2015-05-01 AU AU2015252784A patent/AU2015252784A1/en not_active Abandoned
- 2015-05-01 WO PCT/US2015/028948 patent/WO2015168653A1/fr active Application Filing
- 2015-05-01 JP JP2016565216A patent/JP2017519974A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017519974A (ja) | 2017-07-20 |
| AU2015252784A1 (en) | 2016-11-17 |
| WO2015168653A1 (fr) | 2015-11-05 |
| CN106457078A (zh) | 2017-02-22 |
| EP3137188A1 (fr) | 2017-03-08 |
| EP3137188A4 (fr) | 2018-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20211123 |
|
| FZDE | Discontinued |
Effective date: 20211123 |