CA2945943C - Topical corticosteroid compositions - Google Patents

Topical corticosteroid compositions Download PDF

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Publication number
CA2945943C
CA2945943C CA2945943A CA2945943A CA2945943C CA 2945943 C CA2945943 C CA 2945943C CA 2945943 A CA2945943 A CA 2945943A CA 2945943 A CA2945943 A CA 2945943A CA 2945943 C CA2945943 C CA 2945943C
Authority
CA
Canada
Prior art keywords
composition
alcohol
skin
betamethasone
spray
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2945943A
Other languages
English (en)
French (fr)
Other versions
CA2945943A1 (en
Inventor
Sateesh Kandavilli
Priyadarshani SAHUKAR
Franklin Okumu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promius Pharma LLC
Original Assignee
Promius Pharma LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promius Pharma LLC filed Critical Promius Pharma LLC
Publication of CA2945943A1 publication Critical patent/CA2945943A1/en
Application granted granted Critical
Publication of CA2945943C publication Critical patent/CA2945943C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2945943A 2014-03-11 2015-03-11 Topical corticosteroid compositions Active CA2945943C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461951165P 2014-03-11 2014-03-11
US61/951,165 2014-03-11
PCT/US2015/020031 WO2015138650A1 (en) 2014-03-11 2015-03-11 Topical corticosteroid compositions

Publications (2)

Publication Number Publication Date
CA2945943A1 CA2945943A1 (en) 2015-09-17
CA2945943C true CA2945943C (en) 2020-10-27

Family

ID=52727460

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2945943A Active CA2945943C (en) 2014-03-11 2015-03-11 Topical corticosteroid compositions
CA2946201A Active CA2946201C (en) 2014-03-11 2015-09-09 Topical corticosteroid compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2946201A Active CA2946201C (en) 2014-03-11 2015-09-09 Topical corticosteroid compositions

Country Status (13)

Country Link
US (4) US20150258119A1 (OSRAM)
EP (2) EP3116473B1 (OSRAM)
JP (2) JP6487949B2 (OSRAM)
KR (2) KR101930244B1 (OSRAM)
CN (1) CN106659682B (OSRAM)
AU (2) AU2015229403B2 (OSRAM)
BR (1) BR112016021023A2 (OSRAM)
CA (2) CA2945943C (OSRAM)
EA (2) EA201691808A8 (OSRAM)
ES (1) ES2857602T3 (OSRAM)
MX (2) MX381164B (OSRAM)
WO (2) WO2015138650A1 (OSRAM)
ZA (1) ZA201606704B (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5833007B2 (ja) 2009-08-31 2015-12-16 ドクター・レディーズ・ラボラトリーズ・リミテッド ステロイドを含む局所製剤
US20160184431A1 (en) 2014-03-11 2016-06-30 Promius Pharma Llc Topical compositions comprising a corticosteroid
WO2017091168A1 (en) * 2015-11-28 2017-06-01 Pharmacti̇ve İlaç San. Ve Ti̇c. A.Ş. A topical spray comprising isoconazole nitrate and difluocortolone valerate
US11291672B2 (en) 2016-01-12 2022-04-05 Grace Therapeutics Inc. Betamethasone oral spray formulation and method of use to treat ataxia
GB201604316D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy
US20180028766A1 (en) * 2016-07-27 2018-02-01 Sun Pharmaceutical Industries Limited Touch-free topical spray of halobetasol
CN109789111B (zh) 2016-09-21 2021-11-16 埃维克辛公司 药物组合物
US10543177B2 (en) 2017-04-11 2020-01-28 Kevin Mrohs Composition and method for treating skin conditions
WO2019161178A1 (en) 2018-02-19 2019-08-22 Invue Security Products Inc. Merchandise security system with inductive charging
EP3856155A4 (en) * 2018-09-28 2022-10-05 Joel Studin DELIVERY OF STEROIDS AND LARGE MOLECULES THROUGH THE PORE
JP7412292B2 (ja) * 2019-07-10 2024-01-12 積水化学工業株式会社 製剤
WO2021080527A1 (en) * 2019-10-24 2021-04-29 Pharmacti̇ve İlaç Sanayi̇ Ve Ti̇caret A.Ş. Topical pharmaceutical compositions containing difluocortolone and isoconazole
EP4103151A1 (en) * 2020-02-11 2022-12-21 Taro Pharmaceutical Industries Ltd. Compositions comprising desoximetasone and tazarotene
US11382863B2 (en) * 2020-03-04 2022-07-12 Somerset Therapeutics Llc Injectable suspension comprising an insoluble corticosteroid and a soluble corticosteroid
CN113092601B (zh) * 2021-03-02 2022-12-20 苏州市药品检验检测研究中心 一种化妆品中倍他米松17-丙酸酯及倍他米松21-丙酸酯的检测方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892856A (en) 1974-04-10 1975-07-01 Squibb & Sons Inc Topical steroid formulation
US3934013A (en) 1975-02-21 1976-01-20 Syntex (U.S.A.) Inc. Pharmaceutical composition
US4343798A (en) 1981-06-23 1982-08-10 The Procter & Gamble Company Topical antimicrobial anti-inflammatory compositions
US4552872A (en) * 1983-06-21 1985-11-12 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing corticosteroids
WO1991008733A1 (en) * 1989-12-20 1991-06-27 Schering Corporation Stable cream and lotion bases for lipophilic drug compositions
IT1247529B (it) 1991-04-24 1994-12-17 Poli Ind Chimica Spa Composizioni farmaceutiche in forma di schiuma per somministrazione intravaginale, cutanea e orale
DE19536244A1 (de) 1994-09-30 1996-04-04 Juergen Dr Regenold Pharmazeutische Zusammensetzung zur lokalen Applikation
GB9504265D0 (en) 1995-03-03 1995-04-19 Medeva Plc Corticosteroid-containing pharmaceutical composition
IL152486A0 (en) * 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US20080206161A1 (en) * 2002-10-25 2008-08-28 Dov Tamarkin Quiescent foamable compositions, steroids, kits and uses thereof
US7820145B2 (en) * 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
CL2004001884A1 (es) * 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
ZA200507018B (en) * 2003-12-16 2008-02-27 Foamix Ltd Oleaginous pharmaceutical and cosmetic foam
CA2756674C (en) * 2004-08-31 2012-04-03 Stiefel Research Australia Pty Ltd Microemulsion & sub-micron emulsion process & compositions
EP2438910A1 (en) * 2004-08-31 2012-04-11 Stiefel Research Australia Pty Ltd Microemulsion & sub-micron emulsion process & compositions
US20060246098A1 (en) * 2005-03-16 2006-11-02 Srinivasa Rao Stable aqueous-based emulsion formulation comprising urea and salicylic acid and method of using same
AU2006241285B2 (en) 2005-04-25 2011-04-14 Dermalogix Partners, Inc. Use of a clobetasol spray formulation to treat psoriasis
GB2443162B (en) 2006-10-28 2011-02-09 Nupharm Lab Ltd Betamethasone spray
JP5833007B2 (ja) * 2009-08-31 2015-12-16 ドクター・レディーズ・ラボラトリーズ・リミテッド ステロイドを含む局所製剤
EP2482788B1 (en) * 2009-10-02 2022-12-14 Journey Medical Corporation Topical tetracycline compositions
NL2004437C2 (en) * 2010-03-19 2011-09-20 Forte Iq B V Spray-pumpable comprising composition suitable for topical skin application.
CA2802041A1 (en) * 2010-06-11 2011-12-15 Precision Dermatology, Inc. High oil-content emollient aerosol foam compositions
BR112015002784A2 (pt) * 2012-08-10 2017-07-04 Asahi Glass Co Ltd processo para a produção de um composto carbonato e processo para a produção de policarbonato aromático
CN105188758A (zh) * 2013-03-15 2015-12-23 梅迪奇斯医药公司 氟尼缩松的局部组合物及治疗方法
US10111956B2 (en) * 2013-06-03 2018-10-30 Tolmar, Inc. Corticosteroid compositions

Also Published As

Publication number Publication date
EA201691808A8 (ru) 2017-04-28
AU2015385750A1 (en) 2016-10-27
MX2016011842A (es) 2017-02-02
CA2945943A1 (en) 2015-09-17
US20180250312A1 (en) 2018-09-06
ES2857602T3 (es) 2021-09-29
MX381164B (es) 2025-03-12
KR101930246B1 (ko) 2018-12-18
AU2015385750B2 (en) 2019-01-31
US20160030450A1 (en) 2016-02-04
EP3197432A1 (en) 2017-08-02
CA2946201C (en) 2020-10-27
BR112016021023A8 (pt) 2018-01-30
KR20160144377A (ko) 2016-12-16
WO2016144381A1 (en) 2016-09-15
JP2017530974A (ja) 2017-10-19
ZA201606704B (en) 2019-07-31
US20150258119A1 (en) 2015-09-17
WO2015138650A1 (en) 2015-09-17
EA201691808A1 (ru) 2017-02-28
AU2015229403B2 (en) 2019-05-02
JP6487949B2 (ja) 2019-03-20
BR112016021023A2 (pt) 2021-09-14
CN106659682A (zh) 2017-05-10
KR101930244B1 (ko) 2018-12-18
CN106659682B (zh) 2020-12-29
EP3116473A1 (en) 2017-01-18
KR20170023791A (ko) 2017-03-06
EP3197432A4 (en) 2018-10-10
US20200230155A1 (en) 2020-07-23
EP3116473B1 (en) 2020-12-30
EA201692334A1 (ru) 2018-02-28
JP6535735B2 (ja) 2019-06-26
AU2015229403A1 (en) 2016-10-27
CA2946201A1 (en) 2016-09-15
MX2016011841A (es) 2017-02-02
JP2017508802A (ja) 2017-03-30

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Effective date: 20170223

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Effective date: 20240913