CA2943681A1 - Humanized anti-tf-antigen antibodies - Google Patents
Humanized anti-tf-antigen antibodies Download PDFInfo
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- CA2943681A1 CA2943681A1 CA2943681A CA2943681A CA2943681A1 CA 2943681 A1 CA2943681 A1 CA 2943681A1 CA 2943681 A CA2943681 A CA 2943681A CA 2943681 A CA2943681 A CA 2943681A CA 2943681 A1 CA2943681 A1 CA 2943681A1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461981240P | 2014-04-18 | 2014-04-18 | |
| US61/981,240 | 2014-04-18 | ||
| PCT/US2015/026595 WO2015161311A2 (en) | 2014-04-18 | 2015-04-20 | Humanized anti-tf-antigen antibodies |
Publications (1)
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| CA2943681A1 true CA2943681A1 (en) | 2015-10-22 |
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| CA2943681A Pending CA2943681A1 (en) | 2014-04-18 | 2015-04-20 | Humanized anti-tf-antigen antibodies |
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| Country | Link |
|---|---|
| US (1) | US11130821B2 (enExample) |
| EP (2) | EP3131581B1 (enExample) |
| JP (1) | JP6740135B2 (enExample) |
| KR (1) | KR102413809B1 (enExample) |
| CN (1) | CN106488774B (enExample) |
| AU (1) | AU2015247358B2 (enExample) |
| BR (1) | BR112016024214B8 (enExample) |
| CA (1) | CA2943681A1 (enExample) |
| ES (1) | ES2843546T3 (enExample) |
| MX (2) | MX378944B (enExample) |
| RU (1) | RU2699717C2 (enExample) |
| WO (1) | WO2015161311A2 (enExample) |
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| EP3609922A2 (en) * | 2017-04-13 | 2020-02-19 | Aduro Biotech Holdings, Europe B.V. | Anti-sirp alpha antibodies |
| MA50195A (fr) * | 2017-09-22 | 2020-07-29 | Immunogen Inc | Séparation d'anticorps à chaîne triple légère à l'aide d'une chromatographie à échange de cations |
| CN120586086A (zh) * | 2018-03-28 | 2025-09-05 | 田边三菱制药株式会社 | cMET单克隆结合剂的药物缀合物及其用途 |
| CA3100896C (en) * | 2018-05-30 | 2023-08-29 | National Health Research Institutes | Anti-abeta antibodies and uses thereof |
| KR20220032646A (ko) | 2018-12-21 | 2022-03-15 | 오제 이뮈노테라프틱스 | 인간화된 항-인간-pd-1 항체 |
| WO2020127369A1 (en) | 2018-12-21 | 2020-06-25 | Ose Immunotherapeutics | Bifunctional molecule directed against human pd-1 |
| EP3898676A1 (en) | 2018-12-21 | 2021-10-27 | OSE Immunotherapeutics | Bifunctional anti-pd-1/sirpa molecule |
| CA3123338A1 (en) | 2018-12-21 | 2020-06-25 | Ose Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
| WO2020165374A1 (en) | 2019-02-14 | 2020-08-20 | Ose Immunotherapeutics | Bifunctional molecule comprising il-15ra |
| KR20220157446A (ko) * | 2020-03-23 | 2022-11-29 | 브리스톨-마이어스 스큅 컴퍼니 | 암을 치료하기 위한 항-ccr8 항체 |
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| WO2006012616A2 (en) | 2004-07-26 | 2006-02-02 | The Research Foundation Of State University Of New York At Buffalo Stor Intellectual Property Division | Therapeutic use of anti-tf-antigen antibody |
| GB0510790D0 (en) * | 2005-05-26 | 2005-06-29 | Syngenta Crop Protection Ag | Anti-CD16 binding molecules |
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| WO2011045080A2 (en) * | 2009-10-16 | 2011-04-21 | Biorealites S.A.S. | Monoclonal antibodies to progastrin and their uses |
| EP2347769A1 (en) * | 2010-01-20 | 2011-07-27 | Glycotope GmbH | Cancer stem cell markers and uses thereof |
| EP2407487A1 (en) * | 2010-07-14 | 2012-01-18 | F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. | Multispecific modular antibody |
| CA2832389A1 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
| EP2787081A4 (en) * | 2011-11-30 | 2015-10-07 | Chugai Pharmaceutical Co Ltd | PHARMACEUTICAL CARRIER IN CELLS FOR THE FORMATION OF AN IMMUNOMOPLEX |
| CN102796144A (zh) * | 2012-08-22 | 2012-11-28 | 山东大学 | Tf抗原及其类似物、和其化学酶法合成方法及其应用 |
| US10023651B2 (en) * | 2014-04-18 | 2018-07-17 | The Research Foundation For The State University Of New York | Humanized anti-TF-antigen antibodies |
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2015
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- 2015-04-20 ES ES15780559T patent/ES2843546T3/es active Active
- 2015-04-20 WO PCT/US2015/026595 patent/WO2015161311A2/en not_active Ceased
- 2015-04-20 AU AU2015247358A patent/AU2015247358B2/en active Active
- 2015-04-20 CN CN201580027114.8A patent/CN106488774B/zh active Active
- 2015-04-20 EP EP15780559.9A patent/EP3131581B1/en active Active
- 2015-04-20 RU RU2016143552A patent/RU2699717C2/ru active
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- 2015-04-20 EP EP20197413.6A patent/EP3797793A1/en active Pending
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| EP3797793A1 (en) | 2021-03-31 |
| ES2843546T3 (es) | 2021-07-19 |
| CN106488774B (zh) | 2019-11-01 |
| WO2015161311A2 (en) | 2015-10-22 |
| CN106488774A (zh) | 2017-03-08 |
| BR112016024214A2 (pt) | 2018-01-23 |
| AU2015247358B2 (en) | 2020-02-27 |
| BR112016024214B8 (pt) | 2023-12-26 |
| RU2699717C2 (ru) | 2019-09-09 |
| RU2016143552A3 (enExample) | 2018-11-14 |
| JP6740135B2 (ja) | 2020-08-12 |
| US11130821B2 (en) | 2021-09-28 |
| KR20170010356A (ko) | 2017-01-31 |
| EP3131581A2 (en) | 2017-02-22 |
| AU2015247358A1 (en) | 2016-11-10 |
| US20180258182A1 (en) | 2018-09-13 |
| MX2016013686A (es) | 2017-03-31 |
| EP3131581B1 (en) | 2020-09-23 |
| WO2015161311A3 (en) | 2015-12-10 |
| BR112016024214B1 (pt) | 2023-11-14 |
| KR102413809B1 (ko) | 2022-06-28 |
| MX378944B (es) | 2025-03-10 |
| MX2021000439A (es) | 2021-03-25 |
| RU2016143552A (ru) | 2018-05-21 |
| JP2017518260A (ja) | 2017-07-06 |
| EP3131581A4 (en) | 2018-02-21 |
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