CA2943328C - Methode de preparation d'immunoglobulines - Google Patents

Methode de preparation d'immunoglobulines Download PDF

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Publication number
CA2943328C
CA2943328C CA2943328A CA2943328A CA2943328C CA 2943328 C CA2943328 C CA 2943328C CA 2943328 A CA2943328 A CA 2943328A CA 2943328 A CA2943328 A CA 2943328A CA 2943328 C CA2943328 C CA 2943328C
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Canada
Prior art keywords
solution
immunoglobulins
concentration
caprylate
peg
Prior art date
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Application number
CA2943328A
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English (en)
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CA2943328A1 (fr
Inventor
Pere Ristol Debart
Salvador Grancha Gamon
Juan Ignacio Jorquera Nieto
Maria Mercedes Faro Tomas
Nuria Jorba Grifols
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Instituto Grifols SA
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Instituto Grifols SA
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Publication date
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Priority to CA2943328A priority Critical patent/CA2943328C/fr
Publication of CA2943328A1 publication Critical patent/CA2943328A1/fr
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Publication of CA2943328C publication Critical patent/CA2943328C/fr
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Abstract

La présente invention concerne une méthode de préparation dune solution dimmunoglobulines fondée sur une solution initiale dimmunoglobulines dont la pureté est plus grande ou égale à 96 % en présence dun polyéther ou dun polymère de glycol. Elle comprend les étapes suivantes : a) ajouter de lacide caprylique ou des sels connexes à la solution initiale; b) ajuster le pH de la solution obtenue en a); c) incuber la solution obtenue en b) selon une durée et une température nécessaires pour inactiver les virus enveloppés; d) réaliser une étape dultrafiltration/de diafiltration sur la solution obtenue en c).
CA2943328A 2016-09-26 2016-09-26 Methode de preparation d'immunoglobulines Active CA2943328C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2943328A CA2943328C (fr) 2016-09-26 2016-09-26 Methode de preparation d'immunoglobulines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2943328A CA2943328C (fr) 2016-09-26 2016-09-26 Methode de preparation d'immunoglobulines

Publications (2)

Publication Number Publication Date
CA2943328A1 CA2943328A1 (fr) 2018-03-26
CA2943328C true CA2943328C (fr) 2021-08-03

Family

ID=61759260

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2943328A Active CA2943328C (fr) 2016-09-26 2016-09-26 Methode de preparation d'immunoglobulines

Country Status (1)

Country Link
CA (1) CA2943328C (fr)

Also Published As

Publication number Publication date
CA2943328A1 (fr) 2018-03-26

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Effective date: 20190606