CA2936548C - The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders - Google Patents

The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders Download PDF

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Publication number
CA2936548C
CA2936548C CA2936548A CA2936548A CA2936548C CA 2936548 C CA2936548 C CA 2936548C CA 2936548 A CA2936548 A CA 2936548A CA 2936548 A CA2936548 A CA 2936548A CA 2936548 C CA2936548 C CA 2936548C
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CA
Canada
Prior art keywords
mice
pharmaceutical composition
gtb
glyceryl
eae
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2936548A
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English (en)
French (fr)
Other versions
CA2936548A1 (en
Inventor
Kalipada PAHAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rush University Medical Center
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Rush University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rush University Medical Center filed Critical Rush University Medical Center
Publication of CA2936548A1 publication Critical patent/CA2936548A1/en
Application granted granted Critical
Publication of CA2936548C publication Critical patent/CA2936548C/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA2936548A 2014-01-17 2015-01-16 The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders Active CA2936548C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461928622P 2014-01-17 2014-01-17
US61/928,622 2014-01-17
PCT/US2015/011798 WO2015109215A1 (en) 2014-01-17 2015-01-16 The use of a benzoate containing composition in urea cycle disorders and neurodegenerativre disordrs

Publications (2)

Publication Number Publication Date
CA2936548A1 CA2936548A1 (en) 2015-07-23
CA2936548C true CA2936548C (en) 2022-08-30

Family

ID=53543490

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2936548A Active CA2936548C (en) 2014-01-17 2015-01-16 The use of a benzoate containing composition in urea cycle disorders and neurodegenerative disorders

Country Status (16)

Country Link
US (1) US9968582B2 (enExample)
EP (1) EP3094616B1 (enExample)
JP (2) JP6836905B2 (enExample)
CA (1) CA2936548C (enExample)
CY (1) CY1124115T1 (enExample)
DK (1) DK3094616T3 (enExample)
ES (1) ES2853974T3 (enExample)
HR (1) HRP20210361T1 (enExample)
HU (1) HUE053671T2 (enExample)
LT (1) LT3094616T (enExample)
PL (1) PL3094616T3 (enExample)
PT (1) PT3094616T (enExample)
RS (1) RS61611B1 (enExample)
SI (1) SI3094616T1 (enExample)
SM (1) SMT202100074T1 (enExample)
WO (1) WO2015109215A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020536098A (ja) * 2017-10-06 2020-12-10 ラッシュ・ユニバーシティ・メディカル・センター グリシン脳症を治療するためのベンゾエート含有組成物の使用
EP3713556A4 (en) * 2017-11-22 2021-10-20 Chieh-Hsin Lin BENZOIC ACID OR A SALT AND DERIVATIVE THEREOF FOR USE IN THE PREVENTION OR TREATMENT OF DEPRESSION
EA202192199A1 (ru) 2019-02-25 2021-12-17 Раш Юниверсити Медикал Сентер Композиции, содержащие коричную кислоту, и способы их применения
JP2022541021A (ja) * 2019-07-16 2022-09-21 ラッシュ・ユニバーシティ・メディカル・センター 神経変性障害を治療するためのベンゾエート含有組成物の使用
CN116390761A (zh) 2020-10-28 2023-07-04 拉什大学医学中心 肉桂酸苄酯组合物在治疗甘氨酸脑病和尿素循环障碍中的应用
WO2022132894A1 (en) * 2020-12-16 2022-06-23 Rush University Medical Center Administration of glycerol tribenzoate and glycerol phenylbutyrate for treatment of neurodegenerative and urea cycle disorders
EP4447952A4 (en) * 2021-12-16 2025-11-19 Us Gov Veterans Affairs Benzoic acid salts for the treatment of injuries and disorders of the nervous system

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284647A (en) * 1980-03-31 1981-08-18 The Johns Hopkins University Process for waste nitrogen removal
US20080171792A1 (en) * 2006-12-28 2008-07-17 Jobdevairakkam Christopher New Use of highly concentrated formulations of 4-phenylbutyrate for treatment of certain disorders

Also Published As

Publication number Publication date
RS61611B1 (sr) 2021-04-29
SI3094616T1 (sl) 2021-07-30
HRP20210361T1 (hr) 2021-04-16
LT3094616T (lt) 2021-04-12
SMT202100074T1 (it) 2021-05-07
JP2017505811A (ja) 2017-02-23
DK3094616T3 (da) 2021-02-15
HUE053671T2 (hu) 2021-07-28
PT3094616T (pt) 2021-03-03
ES2853974T3 (es) 2021-09-20
EP3094616A4 (en) 2017-08-23
CA2936548A1 (en) 2015-07-23
WO2015109215A1 (en) 2015-07-23
EP3094616B1 (en) 2020-12-23
CY1124115T1 (el) 2022-05-27
JP2020037558A (ja) 2020-03-12
EP3094616A1 (en) 2016-11-23
JP6836905B2 (ja) 2021-03-03
PL3094616T3 (pl) 2021-05-31
US20160331714A1 (en) 2016-11-17
US9968582B2 (en) 2018-05-15

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