CA2931005C - Agents ciblant le cartilage et leur utilisation - Google Patents

Agents ciblant le cartilage et leur utilisation

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Publication number
CA2931005C
CA2931005C CA2931005A CA2931005A CA2931005C CA 2931005 C CA2931005 C CA 2931005C CA 2931005 A CA2931005 A CA 2931005A CA 2931005 A CA2931005 A CA 2931005A CA 2931005 C CA2931005 C CA 2931005C
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CA
Canada
Prior art keywords
pro
asn
trh
glp
seq
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CA2931005A
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English (en)
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CA2931005A1 (fr
Inventor
Jeffrey Baron
Crystal Sao Fong Cheung
Julian Chun Kin Lui
Dimiter Dimitrov
Zhongyu Zhu
Original Assignee
US Department of Health and Human Services
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Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Priority claimed from PCT/US2015/011433 external-priority patent/WO2015108998A2/fr
Publication of CA2931005A1 publication Critical patent/CA2931005A1/fr
Application granted granted Critical
Publication of CA2931005C publication Critical patent/CA2931005C/fr
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Abstract

Des anticorps monoclonaux et des fragments d'anticorps qui se lient spécifiquement à la matriline-3, des conjugués comprenant ces molécules, et des molécules d'acide nucléique codant pour les anticorps, des fragments liant l'antigène et des conjugués, sont divulgués. L'invention concerne également des compositions comprenant les anticorps, les fragments liant l'antigène, les conjugués et molécules d'acide nucléique divulgués. Des méthodes de traitement ou d'inhibition d'un trouble du cartilage chez un sujet, ainsi que des méthodes d'augmentation de la chondrogenèse dans le tissu cartilagineux sont en outre prévus. Les méthodes peuvent être utilisées, par exemple, pour traiter ou inhiber un trouble du cartilage de conjugaison chez un sujet, tel qu'une dysplasie squelettique ou la petite taille.
CA2931005A 2014-01-15 2015-01-14 Agents ciblant le cartilage et leur utilisation Active CA2931005C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461927904P 2014-01-15 2014-01-15
US61/927,904 2014-01-15
PCT/US2015/011433 WO2015108998A2 (fr) 2014-01-15 2015-01-14 Agents ciblant le cartilage et leur utilisation

Publications (2)

Publication Number Publication Date
CA2931005A1 CA2931005A1 (fr) 2015-07-23
CA2931005C true CA2931005C (fr) 2025-09-09

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