CA2918925A1 - Indol and indazol derivatives - Google Patents
Indol and indazol derivatives Download PDFInfo
- Publication number
- CA2918925A1 CA2918925A1 CA2918925A CA2918925A CA2918925A1 CA 2918925 A1 CA2918925 A1 CA 2918925A1 CA 2918925 A CA2918925 A CA 2918925A CA 2918925 A CA2918925 A CA 2918925A CA 2918925 A1 CA2918925 A1 CA 2918925A1
- Authority
- CA
- Canada
- Prior art keywords
- fluoro
- indole
- carboxamide
- methyl
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13186458 | 2013-09-27 | ||
EP13186458.9 | 2013-09-27 | ||
PCT/EP2014/070092 WO2015044072A1 (en) | 2013-09-27 | 2014-09-22 | Indol and indazol derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2918925A1 true CA2918925A1 (en) | 2015-04-02 |
Family
ID=49237120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2918925A Abandoned CA2918925A1 (en) | 2013-09-27 | 2014-09-22 | Indol and indazol derivatives |
Country Status (11)
Country | Link |
---|---|
US (1) | US9708259B2 (ja) |
EP (1) | EP3049391B1 (ja) |
JP (1) | JP6185660B2 (ja) |
KR (1) | KR20160044039A (ja) |
CN (1) | CN105593211B (ja) |
BR (1) | BR112016006154A2 (ja) |
CA (1) | CA2918925A1 (ja) |
HK (1) | HK1220199A1 (ja) |
MX (1) | MX2016001942A (ja) |
RU (1) | RU2016112952A (ja) |
WO (1) | WO2015044072A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201317363D0 (en) * | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
LT3134386T (lt) | 2014-04-23 | 2020-08-10 | Takeda Pharmaceutical Company Limited | Izoindolin-1-ono dariniai kaip cholinerginio muskarininio m1 receptoriaus teigiamo aloesterinio moduliatoriaus aktyvumas, skirtas alzheimerio ligos gydymui |
EP3144308B1 (en) | 2014-05-16 | 2020-06-24 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
DK3347349T3 (da) * | 2015-09-10 | 2019-10-28 | Suven Life Sciences Ltd | Fluorindolderivater som muskarin m1-receptor-positive allosteriske modulatorer |
CN106243012A (zh) * | 2016-08-02 | 2016-12-21 | 北方民族大学 | 新型吲哚类衍生物及其制备方法 |
CN111107902A (zh) * | 2017-03-14 | 2020-05-05 | 丹娜法伯癌症研究所 | Bax活化的用于诱导细胞死亡的小分子致敏 |
WO2019000238A1 (en) | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | 5- (PYRIDIN-3-YL) OXAZOLE ALLOSTERIC MODULATORS OF M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
WO2019000237A1 (en) * | 2017-06-27 | 2019-01-03 | Merck Sharp & Dohme Corp. | ALLOSTERIC MODULATORS OF 3- (1H-PYRAZOL-4-YL) PYRIDINE FROM THE M4 ACETYLCHOLINE MUSCARINIC RECEPTOR |
CA3076757C (en) * | 2017-10-18 | 2022-10-11 | Suven Life Sciences Limited | Heteroaryl compounds as muscarinic m1 receptor positive allosteric modulators |
JP2023541944A (ja) * | 2020-09-17 | 2023-10-04 | エサイエント ファーマシューティカルズ,インコーポレイティド | Mas関連gタンパク質受容体x4のモジュレーター、並びに関連製品及び方法 |
JP7082726B1 (ja) | 2020-12-25 | 2022-06-08 | 株式会社テイエルブイ | 弁装置 |
WO2024112831A1 (en) * | 2022-11-22 | 2024-05-30 | Maze Therapeutics, Inc. | Inhibitors of solute carrier family 6a member 19 (slc6a19) and methods of use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2575154T3 (es) * | 2009-12-17 | 2016-06-24 | Merck Sharp & Dohme Corp. | Moduladores alostéricos positivos del receptor M1 de quinolina amida |
US9012445B2 (en) * | 2012-01-12 | 2015-04-21 | Vanderbilt University | Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors |
US9403802B2 (en) | 2012-03-02 | 2016-08-02 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use therefor |
-
2014
- 2014-09-22 KR KR1020167007926A patent/KR20160044039A/ko not_active Application Discontinuation
- 2014-09-22 RU RU2016112952A patent/RU2016112952A/ru unknown
- 2014-09-22 EP EP14772317.5A patent/EP3049391B1/en not_active Not-in-force
- 2014-09-22 CN CN201480052952.6A patent/CN105593211B/zh not_active Expired - Fee Related
- 2014-09-22 CA CA2918925A patent/CA2918925A1/en not_active Abandoned
- 2014-09-22 JP JP2016517558A patent/JP6185660B2/ja not_active Expired - Fee Related
- 2014-09-22 BR BR112016006154A patent/BR112016006154A2/pt not_active Application Discontinuation
- 2014-09-22 WO PCT/EP2014/070092 patent/WO2015044072A1/en active Application Filing
- 2014-09-22 MX MX2016001942A patent/MX2016001942A/es unknown
-
2016
- 2016-03-28 US US15/082,754 patent/US9708259B2/en active Active
- 2016-07-15 HK HK16108344.8A patent/HK1220199A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP3049391A1 (en) | 2016-08-03 |
MX2016001942A (es) | 2016-06-02 |
US9708259B2 (en) | 2017-07-18 |
RU2016112952A (ru) | 2017-10-30 |
WO2015044072A1 (en) | 2015-04-02 |
JP2016534026A (ja) | 2016-11-04 |
JP6185660B2 (ja) | 2017-08-23 |
US20160207885A1 (en) | 2016-07-21 |
CN105593211A (zh) | 2016-05-18 |
CN105593211B (zh) | 2021-07-27 |
EP3049391B1 (en) | 2018-12-26 |
HK1220199A1 (zh) | 2017-04-28 |
KR20160044039A (ko) | 2016-04-22 |
BR112016006154A2 (pt) | 2017-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2918925A1 (en) | Indol and indazol derivatives | |
CN111601799B (zh) | 作为Il-17调节剂的稠合咪唑衍生物 | |
CA2747784C (en) | Imidazole compounds for use as enzyme inhibitors | |
JP2023087046A (ja) | ムスカリンm1受容体アゴニストとしての二環式アザ化合物 | |
CA2822166C (en) | Indazolyl triazole derivatives as irak inhibitors | |
TWI344961B (en) | Novel indazole derivative | |
CA2849336A1 (en) | Cyanomethylpyrazole carboxamides as janus kinase inhibitors | |
JP2007514690A (ja) | ヒスタミンh3アンタゴニストとしてのベンズアゼピン誘導体 | |
EA016888B1 (ru) | Производные бензимидазола | |
TW201125864A (en) | Novel compounds as casein kinase inhibitors | |
CA2915952A1 (en) | Pyrrolopyridine or pyrazolopyridine derivatives | |
JP6271758B2 (ja) | フルオロ−ナフチル誘導体 | |
AU2013275209A1 (en) | Branched chain alkyl heteroaromatic ring derivative | |
KR101842382B1 (ko) | 모폴린-피리딘 유도체 | |
AU2008256803A1 (en) | Azacyclylbenzamide derivatives as histamine-3 antagonists | |
JP2013503126A (ja) | Nk3受容体アンタゴニストとしてのピロリジン誘導体 | |
JP6762300B2 (ja) | アミノピラゾール誘導体 | |
JP5452622B2 (ja) | Nk3受容体アンタゴニストとしてのピロリジン誘導体 | |
TW201718542A (zh) | 化合物或其可藥用鹽、藥物組合物及其用途 | |
WO2021099527A1 (en) | Pyrrolidine derivatives | |
WO2015173393A1 (en) | Oxindole compounds carrying a nitrogen-bound spiro substituent and use thereof for treating vasopressin-related diseases |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |
Effective date: 20180924 |