CA2914536A1 - Compositions and methods for modulating foxp3 expression - Google Patents
Compositions and methods for modulating foxp3 expression Download PDFInfo
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- CA2914536A1 CA2914536A1 CA2914536A CA2914536A CA2914536A1 CA 2914536 A1 CA2914536 A1 CA 2914536A1 CA 2914536 A CA2914536 A CA 2914536A CA 2914536 A CA2914536 A CA 2914536A CA 2914536 A1 CA2914536 A1 CA 2914536A1
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- foxp3
- single stranded
- oligonucleotide
- stranded oligonucleotide
- nucleotides
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| AU2013262699A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating ATP2A2 expression |
| BR112014028631A2 (pt) | 2012-05-16 | 2017-10-17 | Rana Therapeutics Inc | composições e métodos para modulação da expressão da família de genes da hemoglobina |
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| SG11201607339VA (en) * | 2014-03-13 | 2016-10-28 | Hoffmann La Roche | Methods and compositions for modulating estrogen receptor mutants |
| WO2017181026A1 (en) * | 2016-04-15 | 2017-10-19 | Translate Bio Ma, Inc. | Selective modulation of foxp3 expression |
| WO2017184082A1 (en) * | 2016-04-22 | 2017-10-26 | Nanyang Technological University | A lymphocyte permeating chimeric oligonucleotide, methods and uses thereof |
| WO2018031871A1 (en) * | 2016-08-12 | 2018-02-15 | Translate Bio Ma, Inc. | Ex vivo modulation of foxp3 expression |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| CA3043768A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| US12024715B2 (en) * | 2017-11-07 | 2024-07-02 | Temple University-Of The Commonwealth System Of Higher Education | Compositions and methods for improved T cells |
| US20210340536A1 (en) * | 2018-09-26 | 2021-11-04 | AUM LifeTech, Inc. | 2' fana modified foxp3 antisense oligonucleotides and methods of use thereof |
| TW202028222A (zh) | 2018-11-14 | 2020-08-01 | 美商Ionis製藥公司 | Foxp3表現之調節劑 |
| CN111378622B (zh) * | 2018-12-29 | 2022-12-02 | 华东师范大学 | 核酸编码的car-t细胞及其制备方法和应用 |
| WO2020160163A1 (en) * | 2019-01-29 | 2020-08-06 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing app expression |
| CA3136172A1 (en) * | 2019-04-18 | 2020-10-22 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of usher syndrome |
| US11866708B2 (en) * | 2019-10-22 | 2024-01-09 | Board Of Regents, The University Of Texas System | Tailored modulation of gene regulation programs via functional enhancer RNA |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| CA3189922A1 (en) | 2020-07-28 | 2022-02-03 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing app expression |
| WO2022088342A1 (zh) * | 2020-10-28 | 2022-05-05 | 苏州吉玛基因股份有限公司 | 一种靶向FOXP3基因的siRNA及其修饰方法 |
| US20250188476A1 (en) * | 2021-06-18 | 2025-06-12 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing ifnar1 expression |
| WO2023235838A2 (en) * | 2022-06-02 | 2023-12-07 | Skyhawk Therapeutics, Inc. | Rna-targeting splicing modifiers for treatment of foxp3-associated conditions and diseases |
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| EP1967525B1 (en) * | 2001-05-08 | 2012-11-14 | Darwin Molecular Corporation | A method for regulating immune function in primates using the foxp3 protein |
| US8029985B2 (en) * | 2004-09-01 | 2011-10-04 | Vybion, Inc. | Amplified bioassay |
| US8629108B2 (en) * | 2006-06-27 | 2014-01-14 | Opexa Therapeutics, Inc. | Rheumatoid arthritis T cell vaccine |
| EP2064350B1 (en) * | 2006-11-27 | 2013-01-02 | Ludwig Institute for Cancer Research Ltd. | Expression of foxp3 by cancer cells |
| WO2008103761A2 (en) * | 2007-02-20 | 2008-08-28 | Sequenom, Inc. | Methods and compositions for cancer diagnosis and treatment based on nucleic acid methylation |
| US8158596B2 (en) * | 2007-05-11 | 2012-04-17 | The Regents Of The University Of Michigan | Materials and methods for FOXP3 tumor suppression |
| US20120004278A1 (en) * | 2010-06-18 | 2012-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Linc rnas in cancer diagnosis and treatment |
| EP2591797A4 (en) * | 2010-07-09 | 2014-01-15 | Inst Pasteur Of Shanghai Cas | REGULATORY FACTOR OF FOXP3 AND REGULATORY T CELLS AND USE THEREOF |
| WO2012020839A1 (ja) * | 2010-08-12 | 2012-02-16 | 塩野義製薬株式会社 | 癌治療用医薬組成物 |
| BR112013005806B1 (pt) * | 2010-09-10 | 2022-05-10 | Epizyme, Inc | Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2 |
| US9920317B2 (en) * | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| WO2012075114A2 (en) * | 2010-12-01 | 2012-06-07 | Ablitech, Inc. | Nucleic acid-polymer conjugates and uses thereof |
| EP2850183A4 (en) * | 2012-05-16 | 2016-02-10 | Rana Therapeutics Inc | COMPOSITIONS AND METHOD FOR MODULATING GENE EXPRESSION |
| WO2013173652A1 (en) * | 2012-05-16 | 2013-11-21 | Rana Therapeutics, Inc. | Compositions and methods for modulating gene expression |
| EA201492117A1 (ru) * | 2012-05-16 | 2015-04-30 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии bdnf |
| US9567581B2 (en) * | 2012-08-07 | 2017-02-14 | The General Hospital Corporation | Selective reactivation of genes on the inactive X chromosome |
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| EP3004354A4 (en) | 2017-01-11 |
| KR20160027968A (ko) | 2016-03-10 |
| US20160122760A1 (en) | 2016-05-05 |
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| AU2014274730A1 (en) | 2016-01-21 |
| JP2016521556A (ja) | 2016-07-25 |
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