CA2914500C - A quinoline inhibitor of the macrophage stimulating 1 receptor mst1 r - Google Patents
A quinoline inhibitor of the macrophage stimulating 1 receptor mst1 r Download PDFInfo
- Publication number
- CA2914500C CA2914500C CA2914500A CA2914500A CA2914500C CA 2914500 C CA2914500 C CA 2914500C CA 2914500 A CA2914500 A CA 2914500A CA 2914500 A CA2914500 A CA 2914500A CA 2914500 C CA2914500 C CA 2914500C
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- Prior art keywords
- pyrazole
- ethyl
- dimethoxyquinolin
- oxy
- cancer
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Classifications
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
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- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13002926.7 | 2013-06-06 | ||
| EP13002926 | 2013-06-06 | ||
| PCT/EP2014/001231 WO2014194975A1 (en) | 2013-06-06 | 2014-05-07 | A quinoline inhibitor of the macrophage stimulating 1 receptor mst1 r |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2914500A1 CA2914500A1 (en) | 2014-12-11 |
| CA2914500C true CA2914500C (en) | 2021-04-20 |
Family
ID=48576706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2914500A Active CA2914500C (en) | 2013-06-06 | 2014-05-07 | A quinoline inhibitor of the macrophage stimulating 1 receptor mst1 r |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9481668B2 (enExample) |
| EP (1) | EP3003315B1 (enExample) |
| JP (1) | JP6464395B2 (enExample) |
| CN (1) | CN105307656B (enExample) |
| AU (1) | AU2014277262B2 (enExample) |
| CA (1) | CA2914500C (enExample) |
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| WO2021030358A1 (en) | 2019-08-12 | 2021-02-18 | Regeneron Pharmaceuticals, Inc. | Macrophage stimulating 1 receptor (mst1r) variants and uses thereof |
| TWI812301B (zh) * | 2021-06-24 | 2023-08-11 | 南韓商Ｌｇ化學股份有限公司 | 作為ｒｏｎ抑制劑之新穎尿素衍生物化合物 |
| TW202315628A (zh) * | 2021-06-24 | 2023-04-16 | 南韓商Ｌｇ化學股份有限公司 | 作為ｒｏｎ抑制劑之新穎吡啶衍生物化合物 |
| JP2025500917A (ja) | 2021-12-16 | 2025-01-15 | キネート バイオファーマ インク． | Ｍｅｔキナーゼの阻害剤 |
| WO2025101652A1 (en) * | 2023-11-07 | 2025-05-15 | The Scripps Research Institute | Selective mammalian sterile 20-like kinase 1 (mst1) modulator compounds as therapeutics for diabetes and liver regeneration |
| KR102921178B1 (ko) * | 2023-11-16 | 2026-02-02 | (주)신테카바이오 | 헤테로아릴 유도체 화합물 및 이의 용도 |
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| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| GB9904387D0 (en) | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| US20110053931A1 (en) | 2006-06-08 | 2011-03-03 | John Gaudino | Quinoline compounds and methods of use |
| EP2423208A1 (en) * | 2010-08-28 | 2012-02-29 | Lead Discovery Center GmbH | Pharmaceutically active compounds as Axl inhibitors |
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|---|---|
| AU2014277262A1 (en) | 2016-01-21 |
| CN105307656B (zh) | 2019-02-19 |
| CA2914500A1 (en) | 2014-12-11 |
| AU2014277262B2 (en) | 2019-10-03 |
| NO3003315T3 (enExample) | 2018-06-16 |
| JP2016520627A (ja) | 2016-07-14 |
| WO2014194975A1 (en) | 2014-12-11 |
| ES2663393T3 (es) | 2018-04-12 |
| EP3003315B1 (en) | 2018-01-17 |
| EP3003315A1 (en) | 2016-04-13 |
| US20160115154A1 (en) | 2016-04-28 |
| US9481668B2 (en) | 2016-11-01 |
| IL242915B (en) | 2020-04-30 |
| JP6464395B2 (ja) | 2019-02-06 |
| DK3003315T3 (en) | 2018-04-16 |
| CN105307656A (zh) | 2016-02-03 |
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