CA2910322A1 - Novel vaccines against apicomplexan pathogens - Google Patents

Novel vaccines against apicomplexan pathogens Download PDF

Info

Publication number
CA2910322A1
CA2910322A1 CA2910322A CA2910322A CA2910322A1 CA 2910322 A1 CA2910322 A1 CA 2910322A1 CA 2910322 A CA2910322 A CA 2910322A CA 2910322 A CA2910322 A CA 2910322A CA 2910322 A1 CA2910322 A1 CA 2910322A1
Authority
CA
Canada
Prior art keywords
fusion protein
recombinant fusion
seq
recombinant
parasite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2910322A
Other languages
English (en)
French (fr)
Inventor
Alexander Boes
Holger Spiegel
Edgu Guven
Veronique Beiss
Markus Sack
Andreas Reimann
Rainer Fischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Publication of CA2910322A1 publication Critical patent/CA2910322A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2910322A 2013-04-24 2014-04-24 Novel vaccines against apicomplexan pathogens Abandoned CA2910322A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361815486P 2013-04-24 2013-04-24
US61/815,486 2013-04-24
EP13165161.4 2013-04-24
EP20130165161 EP2796147A1 (en) 2013-04-24 2013-04-24 Novel vaccines against apicomplexan pathoges
PCT/EP2014/058409 WO2014174054A1 (en) 2013-04-24 2014-04-24 Novel vaccines against apicomplexan pathogens

Publications (1)

Publication Number Publication Date
CA2910322A1 true CA2910322A1 (en) 2014-10-30

Family

ID=48143209

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2910322A Abandoned CA2910322A1 (en) 2013-04-24 2014-04-24 Novel vaccines against apicomplexan pathogens

Country Status (5)

Country Link
US (1) US10131697B2 (https=)
EP (2) EP2796147A1 (https=)
JP (1) JP6461100B2 (https=)
CA (1) CA2910322A1 (https=)
WO (1) WO2014174054A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3081575A1 (en) 2015-04-12 2016-10-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Anti-plasmodium parasite antibodies
US20180311326A1 (en) * 2015-11-10 2018-11-01 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Immunoassemblin (ia) protein complexes
US20180372742A1 (en) * 2015-12-10 2018-12-27 Immport Therapeutics, Inc. Babesia Biomarkers for Diagnostic and Screening In Vitro Diagnostic Test
US12544441B2 (en) 2016-11-01 2026-02-10 Washington University Compositions comprising CelTOS immunogens and antibodies and method of use thereof
US12398184B2 (en) 2016-11-01 2025-08-26 Washington University Compositions comprising CelTOS immunogens and antibodies and method of use thereof
US11273212B2 (en) 2016-11-11 2022-03-15 Sumitomo Dainippon Pharma Co., Ltd. Malaria vaccine
US20180348218A1 (en) * 2017-06-05 2018-12-06 Tokitae Llc Serology assay for recent malaria infection
EP3946441A1 (en) 2019-04-04 2022-02-09 Statens Serum Institut Multivalent malaria transmission-blocking vaccines
EP4206225A4 (en) 2020-08-26 2024-10-02 National University Corporation Ehime University ANTI-MALARIA PARASITE ANTIBODIES
WO2024092112A2 (en) * 2022-10-27 2024-05-02 University Of Maryland, Baltimore Method for identifying antigenic epitopes in plasmodium falciparum and uses thereof
GB202301244D0 (en) * 2023-01-27 2023-03-15 Univ Oxford Innovation Ltd Vaccine
WO2025100417A1 (ja) * 2023-11-06 2025-05-15 株式会社ダイセル Ａａｖのフルカプシドに対するアフィニティポリペプチド
CN120550099A (zh) * 2025-06-12 2025-08-29 宁夏农林科学院畜牧兽医研究所(有限公司) 一种牛焦虫疫苗制造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2322552C2 (de) 1972-11-06 1986-08-28 Pharmacia AB, Uppsala Verfahren zum Abtrennen von Protein A aus Staphylococcus aureus aus einer Flüssigkeit
US4599231A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4599230A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4608251A (en) 1984-11-09 1986-08-26 Pitman-Moore, Inc. LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
US4601903A (en) 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
BRPI0615400A2 (pt) * 2005-08-31 2011-05-17 Genvec Inc vacinas para malária baseadas em vetor adenoviral
US7931908B2 (en) * 2007-02-23 2011-04-26 Philadelphia Health Education Corporation Chimeric MSP-based malaria vaccine
EP2352751A2 (en) 2008-09-28 2011-08-10 Fraunhofer USA, Inc. Plasmodium vaccines, antigens, compositions and methods
MX355501B (es) * 2010-09-27 2018-04-20 Inovio Pharmaceuticals Inc Star Estructuras de consenso de antigenos y vacunas elaboradas a partir de estas y metodos para utilizarlas en el tratamiento de la malaria.

Also Published As

Publication number Publication date
US10131697B2 (en) 2018-11-20
WO2014174054A1 (en) 2014-10-30
EP2796147A1 (en) 2014-10-29
JP2016523821A (ja) 2016-08-12
EP2988776B1 (en) 2018-12-26
US20160083439A1 (en) 2016-03-24
JP6461100B2 (ja) 2019-01-30
EP2988776A1 (en) 2016-03-02

Similar Documents

Publication Publication Date Title
EP2988776B1 (en) Novel vaccines against apicomplexan pathogens
US10183066B2 (en) Multi-component-multistage malaria vaccines
López et al. What is known about the immune response induced by Plasmodium vivax malaria vaccine candidates?
Arévalo-Herrera et al. Current status of Plasmodium vivax vaccine
JP2017512498A5 (https=)
Sala et al. The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarial transmission blocking immunity both in vivo and in vitro
US20070003562A1 (en) GLURP-MSP3 fusion protein, immunogenic compositions and malarial vaccines containing it
AU2011326338A1 (en) Treatment and prevention of malaria
US9919040B2 (en) Soluble recombinant plasmodium falciparum circumsporozoite protein, use in vaccines, methods of making and uses thereof
US10213501B2 (en) Three-component-multistage malaria vaccine
Hadj-Kaddour et al. Recombinant protein Bd37 protected gerbils against heterologous challenges with isolates of Babesia divergens polymorphic for the bd37 gene
US20180311326A1 (en) Immunoassemblin (ia) protein complexes
Valencia et al. Platform for Plasmodium vivax vaccine discovery and development
Zhang et al. Construction and evaluation of a multistage combination vaccine against malaria
CA2542924A1 (en) Msp-3-like family of genes
Boes et al. LLLLGGG GGGGGGG GGG LLL GGGGGG
EP2501717B1 (en) Enhanced malaria msp-1 subunit vaccine
EP2223937A1 (en) Polypeptides for the prevention or treatment of malaria
EP1808443A1 (en) Purified polypeptide comprising or consisting of a C-terminus MSP1 antigen from Plasmodium falciparum carrying a Glycosyl-phosphatidyl-inositol group (GPI)
Wu et al. Malaria Vaccine Development
Kei Expression of a Hexa-histidine TaggedPlasmodium falciparum Merozoite Surface Protein-1 C-terminal Processing Fragment (C-HisPfMSP-l42) in Silkworm Larvae usingBombyx mori Nuclear Polyhedrosis Virus
Fei Purification and Characterization of A Malaria Vaccine Candidate: Plasmodium falciparum Merozoite Surface Protein-1 C-terminal Processing Fragment (MSP-I42) Expressed by Baculovirus in Silkworm Larvae
Alkahtani Recombinant Expression and Immuno-screening for Vaccine Candidates in Plasmodium falciparum Saad M. Alkahtani Thesis submitted for the degree of Doctor of Philosophy University of Edinburgh
Alaro Development of a novel chimeric blood-stage malaria vaccine
HK1111701A (en) Purified polypeptide comprising or consisting of a c-terminus msp1 antigen from plasmodium falciparum carrying a glycosyl-phosphatidyl-inositol group (gpi)

Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20200831