CA2908240A1 - Blocking of cue-induced drug reinstatement - Google Patents
Blocking of cue-induced drug reinstatement Download PDFInfo
- Publication number
- CA2908240A1 CA2908240A1 CA2908240A CA2908240A CA2908240A1 CA 2908240 A1 CA2908240 A1 CA 2908240A1 CA 2908240 A CA2908240 A CA 2908240A CA 2908240 A CA2908240 A CA 2908240A CA 2908240 A1 CA2908240 A1 CA 2908240A1
- Authority
- CA
- Canada
- Prior art keywords
- ethoxycarbonyl
- drug
- laurate
- acetate
- hydroxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims abstract description 37
- 230000037361 pathway Effects 0.000 claims abstract description 35
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/US2013/033703 WO2013148572A1 (en) | 2012-03-27 | 2013-03-25 | Blocking of cue-induced drug reinstatement |
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| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| CA2806232A1 (en) | 2010-07-23 | 2012-01-26 | Demerx, Inc. | Noribogaine compositions |
| EP2481740B1 (en) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| CA2858820C (en) | 2012-01-25 | 2021-08-17 | Demerx, Inc. | Synthetic voacangine |
| JP2016508979A (ja) * | 2012-12-20 | 2016-03-24 | デメレックス， インコーポレイテッド | 置換ノルイボガイン |
| US20150258110A1 (en) * | 2014-03-13 | 2015-09-17 | Demerx, Inc. | Methods for acute and long-term treatment of alcohol dependence using ibogaine |
| WO2015163844A1 (en) * | 2014-04-21 | 2015-10-29 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| AU2020357951B2 (en) * | 2019-10-01 | 2024-01-11 | Mind Medicine, Inc. | 18-MC for treatment of substance use disorders |
| WO2023278108A1 (en) * | 2021-06-29 | 2023-01-05 | Mind Medicine, Inc. | 18-mc for treating obesity |
| WO2025117491A1 (en) * | 2023-12-01 | 2025-06-05 | Kuleon Llc | Azepino analogs and methods of making and using the same |
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| IL123220A0 (en) * | 1995-08-08 | 1998-09-24 | Albany Medical College | Ibogamine congeners |
| US6780871B2 (en) * | 2001-01-29 | 2004-08-24 | Albany Medical College | Methods and compositions for treating addiction disorders |
| US20030199439A1 (en) * | 2002-04-22 | 2003-10-23 | Simon David Lew | Compositions of alpha3beta4 receptor antagonists and opioid agonist analgesics |
| CA2575995A1 (en) * | 2004-08-13 | 2006-02-16 | Omeros Corporation | Treatment for methamphetamine addiction and reduction of methamphetamine use using serotonin antagonists |
| EA200970369A1 (ru) * | 2006-10-09 | 2009-08-28 | Смитклайн Бичам Корпорейшн | Композиции для снижения симптомов никотиновой абстиненции и/или отказа от употребления табака |
| WO2008087123A2 (en) * | 2007-01-16 | 2008-07-24 | Solvay Pharmaceuticals B.V. | Use of 5-ht6 antagonists to prevent relapse into addiction |
| CA2754901A1 (en) * | 2009-03-11 | 2010-09-16 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US8785472B2 (en) * | 2010-05-11 | 2014-07-22 | National Cheng Kung University | Use of dextromethorphan in treating addictive behavior or bipolar disorder |
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| WO2013148572A1 (en) | 2013-10-03 |
| EP2830601A1 (en) | 2015-02-04 |
| US20150051192A1 (en) | 2015-02-19 |
| JP2015522522A (ja) | 2015-08-06 |
| EP2830601A4 (en) | 2015-09-23 |
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