CA2905004C - Systems and methods for administering spinal cord stimulation based on temporal patterns of electrical stimulation - Google Patents
Systems and methods for administering spinal cord stimulation based on temporal patterns of electrical stimulation Download PDFInfo
- Publication number
- CA2905004C CA2905004C CA2905004A CA2905004A CA2905004C CA 2905004 C CA2905004 C CA 2905004C CA 2905004 A CA2905004 A CA 2905004A CA 2905004 A CA2905004 A CA 2905004A CA 2905004 C CA2905004 C CA 2905004C
- Authority
- CA
- Canada
- Prior art keywords
- scs
- stimulation
- pattern
- patterns
- optimization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000638 stimulation Effects 0.000 title claims abstract description 116
- 230000002123 temporal effect Effects 0.000 title claims abstract description 66
- 238000000034 method Methods 0.000 title claims abstract description 37
- 210000000278 spinal cord Anatomy 0.000 title claims abstract description 17
- 230000000694 effects Effects 0.000 claims abstract description 31
- 238000005457 optimization Methods 0.000 claims abstract description 28
- 210000002569 neuron Anatomy 0.000 claims abstract description 27
- 238000005094 computer simulation Methods 0.000 claims abstract description 13
- 230000006870 function Effects 0.000 claims description 27
- 238000004422 calculation algorithm Methods 0.000 claims description 24
- 238000010304 firing Methods 0.000 claims description 19
- 230000002068 genetic effect Effects 0.000 claims description 14
- 230000000926 neurological effect Effects 0.000 claims description 13
- 210000004126 nerve fiber Anatomy 0.000 claims description 11
- 210000000578 peripheral nerve Anatomy 0.000 claims description 2
- 238000002922 simulated annealing Methods 0.000 claims description 2
- 210000003594 spinal ganglia Anatomy 0.000 claims description 2
- 210000000273 spinal nerve root Anatomy 0.000 claims description 2
- 210000005250 spinal neuron Anatomy 0.000 claims 2
- 230000001537 neural effect Effects 0.000 abstract description 16
- 230000002093 peripheral effect Effects 0.000 description 31
- 238000003860 storage Methods 0.000 description 16
- 208000002193 Pain Diseases 0.000 description 14
- 238000010586 diagram Methods 0.000 description 10
- 239000000835 fiber Substances 0.000 description 9
- 238000012545 processing Methods 0.000 description 9
- 238000004891 communication Methods 0.000 description 7
- 230000005540 biological transmission Effects 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 208000005890 Neuroma Diseases 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 238000013461 design Methods 0.000 description 5
- 208000004296 neuralgia Diseases 0.000 description 5
- 208000021722 neuropathic pain Diseases 0.000 description 5
- 238000004088 simulation Methods 0.000 description 5
- 208000000094 Chronic Pain Diseases 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 238000004590 computer program Methods 0.000 description 4
- 210000005036 nerve Anatomy 0.000 description 4
- 230000006399 behavior Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000002964 excitative effect Effects 0.000 description 3
- 230000003040 nociceptive effect Effects 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 210000001170 unmyelinated nerve fiber Anatomy 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 2
- 208000012902 Nervous system disease Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000001153 interneuron Anatomy 0.000 description 2
- 210000002414 leg Anatomy 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 238000000059 patterning Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 210000001176 projection neuron Anatomy 0.000 description 2
- 230000001902 propagating effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 210000000225 synapse Anatomy 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000938605 Crocodylia Species 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 208000004983 Phantom Limb Diseases 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000000256 facial nerve Anatomy 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000001926 inhibitory interneuron Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000008906 neuronal response Effects 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36071—Pain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36171—Frequency
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
- A61N1/36167—Timing, e.g. stimulation onset
- A61N1/36178—Burst or pulse train parameters
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361779632P | 2013-03-13 | 2013-03-13 | |
| US201361779554P | 2013-03-13 | 2013-03-13 | |
| US61/779,632 | 2013-03-13 | ||
| US61/779,554 | 2013-03-13 | ||
| PCT/US2014/025389 WO2014159880A1 (en) | 2013-03-13 | 2014-03-13 | Systems and methods for administering spinal cord stimulation based on temporal patterns of electrical stimulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2905004A1 CA2905004A1 (en) | 2014-10-02 |
| CA2905004C true CA2905004C (en) | 2023-06-27 |
Family
ID=51625282
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2905004A Active CA2905004C (en) | 2013-03-13 | 2014-03-13 | Systems and methods for administering spinal cord stimulation based on temporal patterns of electrical stimulation |
| CA2905102A Active CA2905102C (en) | 2013-03-13 | 2014-03-13 | Systems and methods for applying electrical stimulation for optimizing spinal cord stimulation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2905102A Active CA2905102C (en) | 2013-03-13 | 2014-03-13 | Systems and methods for applying electrical stimulation for optimizing spinal cord stimulation |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11357983B2 (enExample) |
| EP (2) | EP2968945B1 (enExample) |
| JP (3) | JP2016515026A (enExample) |
| AU (5) | AU2014244318A1 (enExample) |
| CA (2) | CA2905004C (enExample) |
| WO (2) | WO2014159880A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9174053B2 (en) | 2013-03-08 | 2015-11-03 | Boston Scientific Neuromodulation Corporation | Neuromodulation using modulated pulse train |
| JP2017527429A (ja) | 2014-09-15 | 2017-09-21 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 神経刺激パルスパターンをプログラムするためのグラフィカルユーザインターフェイス |
| JP6452836B2 (ja) * | 2014-11-04 | 2019-01-16 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 複合神経刺激パターンをプログラムする方法及び装置 |
| EP3294126A4 (en) * | 2015-05-08 | 2018-12-19 | Duke University | Systems and methods for spinal cord stimulation |
| WO2017019191A1 (en) | 2015-07-30 | 2017-02-02 | Boston Scientific Neuromodulation Corporation | User interface for custom patterned electrical stimulation |
| WO2017066187A1 (en) | 2015-10-15 | 2017-04-20 | Boston Scientific Neuromodulation Corporation | User interface for neurostimulation waveform composition |
| WO2017117434A1 (en) | 2015-12-30 | 2017-07-06 | Boston Scientific Neuromodulation Corporation | System for guided optimization of neurostimulation patterns |
| WO2017117448A1 (en) * | 2015-12-30 | 2017-07-06 | Boston Scientific Neuromodulation Corporation | System for composing neurostimulation patterns for cumulative effects |
| EP4654214A2 (en) | 2015-12-30 | 2025-11-26 | Boston Scientific Neuromodulation Corporation | System for composing neurostimulation patterns using a neuronal network model |
| EP3463551A4 (en) | 2016-06-01 | 2020-01-29 | Duke University | SYSTEMS AND METHODS FOR DETERMINING OPTIMAL TEMPORAL NERVOUS STIMULATION PATTERNS |
| CN109561849B (zh) | 2016-06-24 | 2023-01-13 | 萨鲁达医疗有限公司 | 伪像减少的神经刺激 |
| WO2018119220A1 (en) | 2016-12-21 | 2018-06-28 | Duke University | Method to design temporal patterns of nervous system stimulation |
| US11298546B2 (en) | 2017-12-12 | 2022-04-12 | Duke University | Systems and methods for minimizing response variability of spinal cord stimulation |
| US12397162B2 (en) | 2020-12-15 | 2025-08-26 | Boston Scientific Neuromodulation Corporation | Method and apparatus for generating modulated neurostimulation pulse sequence |
| US20250319312A1 (en) * | 2024-04-15 | 2025-10-16 | Boston Scientific Neuromodulation Corporation | Pathways to pain relief via adaptive electrical neurostimulation treatment |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54119792A (en) | 1978-03-03 | 1979-09-17 | Iriyou Kougaku Kenkiyuushiyo K | Electric stimulation device for removing pain |
| US6944501B1 (en) | 2000-04-05 | 2005-09-13 | Neurospace, Inc. | Neurostimulator involving stimulation strategies and process for using it |
| US5716377A (en) | 1996-04-25 | 1998-02-10 | Medtronic, Inc. | Method of treating movement disorders by brain stimulation |
| US7555346B1 (en) | 1999-01-07 | 2009-06-30 | Boston Scientific Neuromodulation Corporation | Implantable pulse generator having current steering means |
| US7305268B2 (en) | 2000-07-13 | 2007-12-04 | Northstar Neurscience, Inc. | Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators |
| PT102508A (pt) | 2000-08-10 | 2002-02-28 | Maria Candida De Carvalho Ferr | Algoritmos geneticos mistos - lineares e nao-lineares - para resolver problemas tais como optimizacao, descoberta de funcoes, planeamento e sintese logica |
| US6560490B2 (en) | 2000-09-26 | 2003-05-06 | Case Western Reserve University | Waveforms for selective stimulation of central nervous system neurons |
| AU2002227147A1 (en) * | 2000-11-02 | 2002-05-15 | Keith L March | Method and system for modulation of oscillating signals to enhance biologic effects |
| US20070191895A1 (en) | 2001-04-20 | 2007-08-16 | Foreman Robert D | Activation of cardiac alpha receptors by spinal cord stimulation produces cardioprotection against ischemia, arrhythmias, and heart failure |
| US7050856B2 (en) | 2002-01-11 | 2006-05-23 | Medtronic, Inc. | Variation of neural-stimulation parameters |
| US7881805B2 (en) | 2002-02-04 | 2011-02-01 | Boston Scientific Neuromodulation Corporation | Method for optimizing search for spinal cord stimulation parameter settings |
| US7236830B2 (en) | 2002-12-10 | 2007-06-26 | Northstar Neuroscience, Inc. | Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson's disease and/or other movement disorders |
| US7344555B2 (en) | 2003-04-07 | 2008-03-18 | The United States Of America As Represented By The Department Of Health And Human Services | Light promotes regeneration and functional recovery after spinal cord injury |
| JP4174825B2 (ja) | 2003-05-23 | 2008-11-05 | 株式会社テクノリンク | 生体刺激装置 |
| US7239926B2 (en) * | 2003-09-15 | 2007-07-03 | Medtronic, Inc. | Selection of neurostimulator parameter configurations using genetic algorithms |
| US8180601B2 (en) | 2006-03-09 | 2012-05-15 | The Cleveland Clinic Foundation | Systems and methods for determining volume of activation for deep brain stimulation |
| WO2006019764A2 (en) | 2004-07-15 | 2006-02-23 | Northstar Neuroscience, Inc. | Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy |
| US7463927B1 (en) | 2004-09-02 | 2008-12-09 | Intelligent Neurostimulation Microsystems, Llc | Self-adaptive system for the automatic detection of discomfort and the automatic generation of SCS therapies for chronic pain control |
| US8788044B2 (en) | 2005-01-21 | 2014-07-22 | Michael Sasha John | Systems and methods for tissue stimulation in medical treatment |
| WO2007094830A1 (en) * | 2005-11-10 | 2007-08-23 | In Silico Biosciences, Inc. | Method and apparatus for computer modeling the human brain for predicting drug effects |
| US8744597B2 (en) | 2006-06-30 | 2014-06-03 | Medtronic, Inc. | Selecting electrode combinations for stimulation therapy |
| US20090204173A1 (en) | 2007-11-05 | 2009-08-13 | Zi-Ping Fang | Multi-Frequency Neural Treatments and Associated Systems and Methods |
| US8559662B2 (en) | 2008-05-06 | 2013-10-15 | Starkey Laboratories, Inc. | Genetic algorithms with subjective input for hearing assistance devices |
| WO2009139917A2 (en) | 2008-05-15 | 2009-11-19 | Intelect Medical, Inc. | Clinician programmer clinician programmer system and method for generating interface models and displays of volumes of activation |
| AU2009262178A1 (en) | 2008-06-25 | 2009-12-30 | Advanced Neuromodulation Systems, Inc. | Method of electrically stimulating tissue of a patient by shifting a locus of stimulation and system employing the same |
| WO2010039274A1 (en) | 2008-10-03 | 2010-04-08 | Duke University | Non-regular electrical stimulation patterns for treating neurological disorders |
| US8255057B2 (en) * | 2009-01-29 | 2012-08-28 | Nevro Corporation | Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions |
| EP2374083B1 (en) | 2008-12-04 | 2019-05-15 | The Cleveland Clinic Foundation | System and method to define target volume for stimulation in brain |
| US8825168B2 (en) | 2009-09-10 | 2014-09-02 | Cochlear Limited | Using a genetic algorithm employing dynamic mutation |
| CA2800889C (en) | 2010-05-27 | 2018-12-04 | Ndi Medical, Llc | Waveform shapes for treating neurological disorders optimized for energy efficiency |
| WO2012075198A2 (en) * | 2010-11-30 | 2012-06-07 | Nevro Corporation | Extended pain relief via high frequency spinal cord modulation, and associated systems and methods |
| EP4201475A1 (en) | 2011-01-03 | 2023-06-28 | The Regents of the University of California | High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury |
| AU2012230699A1 (en) * | 2011-03-24 | 2013-05-23 | California Institute Of Technology | Neurostimulator |
| US8571667B2 (en) | 2011-07-01 | 2013-10-29 | Greatbatch Ltd. | Active current control using the enclosure of an implanted pulse generator |
| CN102521456A (zh) * | 2011-12-15 | 2012-06-27 | 河海大学常州校区 | 基于神经网络和遗传算法的拱梁优化设计方法 |
| US10639477B2 (en) * | 2014-01-17 | 2020-05-05 | Cardiac Pacemakers, Inc. | Systems and methods for delivering pulmonary therapy |
-
2014
- 2014-03-13 WO PCT/US2014/025389 patent/WO2014159880A1/en not_active Ceased
- 2014-03-13 US US14/774,160 patent/US11357983B2/en active Active
- 2014-03-13 EP EP14776331.2A patent/EP2968945B1/en active Active
- 2014-03-13 CA CA2905004A patent/CA2905004C/en active Active
- 2014-03-13 WO PCT/US2014/025423 patent/WO2014159896A1/en not_active Ceased
- 2014-03-13 JP JP2016501846A patent/JP2016515026A/ja active Pending
- 2014-03-13 US US14/774,156 patent/US10232179B2/en active Active
- 2014-03-13 CA CA2905102A patent/CA2905102C/en active Active
- 2014-03-13 AU AU2014244318A patent/AU2014244318A1/en not_active Abandoned
- 2014-03-13 AU AU2014244386A patent/AU2014244386B2/en active Active
- 2014-03-13 EP EP14773114.5A patent/EP2968944B1/en active Active
- 2014-03-13 JP JP2016501841A patent/JP2016515025A/ja active Pending
-
2018
- 2018-08-14 AU AU2018217227A patent/AU2018217227A1/en not_active Abandoned
-
2019
- 2019-06-06 JP JP2019106026A patent/JP7038080B2/ja active Active
-
2020
- 2020-07-15 AU AU2020205274A patent/AU2020205274A1/en not_active Abandoned
-
2022
- 2022-07-18 AU AU2022206452A patent/AU2022206452B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014244386A1 (en) | 2015-10-01 |
| AU2022206452A1 (en) | 2022-08-11 |
| AU2020205274A1 (en) | 2020-08-06 |
| AU2014244318A1 (en) | 2015-10-01 |
| AU2022206452B2 (en) | 2023-11-16 |
| EP2968944A4 (en) | 2016-11-30 |
| US11357983B2 (en) | 2022-06-14 |
| JP2019162508A (ja) | 2019-09-26 |
| JP2016515025A (ja) | 2016-05-26 |
| EP2968944B1 (en) | 2021-09-01 |
| CA2905004A1 (en) | 2014-10-02 |
| CA2905102C (en) | 2023-07-25 |
| EP2968945A1 (en) | 2016-01-20 |
| US20160038740A1 (en) | 2016-02-11 |
| CA2905102A1 (en) | 2014-10-02 |
| JP2016515026A (ja) | 2016-05-26 |
| US10232179B2 (en) | 2019-03-19 |
| EP2968945B1 (en) | 2022-02-23 |
| AU2018217227A1 (en) | 2018-08-30 |
| WO2014159880A1 (en) | 2014-10-02 |
| WO2014159896A1 (en) | 2014-10-02 |
| AU2014244386B2 (en) | 2018-05-24 |
| US20160022993A1 (en) | 2016-01-28 |
| EP2968944A1 (en) | 2016-01-20 |
| EP2968945A4 (en) | 2016-11-30 |
| JP7038080B2 (ja) | 2022-03-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2905004C (en) | Systems and methods for administering spinal cord stimulation based on temporal patterns of electrical stimulation | |
| US11890477B2 (en) | Systems and methods for spinal cord stimulation | |
| US10702696B2 (en) | Systems and methods for spinal cord stimulation | |
| US12280259B2 (en) | Systems and methods for minimizing response variability of spinal cord stimulation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190306 |
|
| EEER | Examination request |
Effective date: 20190306 |
|
| EEER | Examination request |
Effective date: 20190306 |
|
| EEER | Examination request |
Effective date: 20190306 |
|
| EEER | Examination request |
Effective date: 20190306 |
|
| EEER | Examination request |
Effective date: 20190306 |