CA2899339C - Aqueous ophthalmic solutions of phentolamine and medical uses thereof - Google Patents

Aqueous ophthalmic solutions of phentolamine and medical uses thereof Download PDF

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Publication number
CA2899339C
CA2899339C CA2899339A CA2899339A CA2899339C CA 2899339 C CA2899339 C CA 2899339C CA 2899339 A CA2899339 A CA 2899339A CA 2899339 A CA2899339 A CA 2899339A CA 2899339 C CA2899339 C CA 2899339C
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CA
Canada
Prior art keywords
solution
aqueous ophthalmic
patient
mannitol
phentolamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2899339A
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English (en)
French (fr)
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CA2899339A1 (en
Inventor
Alan Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Opus Genetics Inc
Original Assignee
Ocuphire Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51259735&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2899339(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ocuphire Pharma Inc filed Critical Ocuphire Pharma Inc
Publication of CA2899339A1 publication Critical patent/CA2899339A1/en
Application granted granted Critical
Publication of CA2899339C publication Critical patent/CA2899339C/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2899339A 2013-02-01 2014-01-31 Aqueous ophthalmic solutions of phentolamine and medical uses thereof Active CA2899339C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361759530P 2013-02-01 2013-02-01
US61/759,530 2013-02-01
PCT/US2014/014067 WO2014121027A1 (en) 2013-02-01 2014-01-31 Aqueous ophthalmic solutions of phentolamine and medical uses thereof

Publications (2)

Publication Number Publication Date
CA2899339A1 CA2899339A1 (en) 2014-08-07
CA2899339C true CA2899339C (en) 2021-07-06

Family

ID=51259735

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2899339A Active CA2899339C (en) 2013-02-01 2014-01-31 Aqueous ophthalmic solutions of phentolamine and medical uses thereof

Country Status (9)

Country Link
US (9) US9795560B2 (https=)
EP (1) EP2950648B1 (https=)
JP (1) JP6335927B2 (https=)
AU (2) AU2014212274A1 (https=)
CA (1) CA2899339C (https=)
DK (1) DK2950648T3 (https=)
ES (1) ES2762153T3 (https=)
PT (1) PT2950648T (https=)
WO (1) WO2014121027A1 (https=)

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* Cited by examiner, † Cited by third party
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KR102478553B1 (ko) * 2018-02-28 2022-12-16 한림제약(주) 벤조피란 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 용액 형태의 점안제
HUE058931T2 (hu) 2018-04-24 2022-09-28 Allergan Inc Pilokarpin hidroklorid alkalmazása presbyopia kezelésére
EP3866790A4 (en) 2018-10-15 2022-08-03 Ocuphire Pharma, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF GLAUCOMA AND RELATED DISEASES
CA3116589A1 (en) 2018-10-26 2020-04-30 Ocuphire Pharma, Inc. Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders
CN115368310B (zh) 2021-05-18 2025-06-27 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

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Also Published As

Publication number Publication date
ES2762153T3 (es) 2020-05-22
US11844858B2 (en) 2023-12-19
AU2018200566A1 (en) 2018-02-15
US20220175668A1 (en) 2022-06-09
PT2950648T (pt) 2020-01-06
US20250248930A1 (en) 2025-08-07
EP2950648A1 (en) 2015-12-09
JP6335927B2 (ja) 2018-05-30
AU2014212274A1 (en) 2015-08-13
US20190254963A1 (en) 2019-08-22
WO2014121027A1 (en) 2014-08-07
EP2950648A4 (en) 2016-07-20
US20140221445A1 (en) 2014-08-07
DK2950648T3 (da) 2019-12-02
US11090261B2 (en) 2021-08-17
US20190358152A1 (en) 2019-11-28
EP2950648B1 (en) 2019-09-18
US10772829B2 (en) 2020-09-15
US9795560B2 (en) 2017-10-24
AU2018200566B2 (en) 2019-06-13
US20250248931A1 (en) 2025-08-07
US10278918B2 (en) 2019-05-07
US12350366B2 (en) 2025-07-08
JP2016506966A (ja) 2016-03-07
US20180221274A1 (en) 2018-08-09
CA2899339A1 (en) 2014-08-07
US20250262149A1 (en) 2025-08-21
AU2018200566B9 (en) 2019-06-20
US20240285519A1 (en) 2024-08-29

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