CA2897869A1 - Antibodies that bind to jagged 1 - Google Patents
Antibodies that bind to jagged 1 Download PDFInfo
- Publication number
- CA2897869A1 CA2897869A1 CA2897869A CA2897869A CA2897869A1 CA 2897869 A1 CA2897869 A1 CA 2897869A1 CA 2897869 A CA2897869 A CA 2897869A CA 2897869 A CA2897869 A CA 2897869A CA 2897869 A1 CA2897869 A1 CA 2897869A1
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- CA
- Canada
- Prior art keywords
- antibody
- seq
- notch
- human
- jagged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/3015—Breast
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/3046—Stomach, Intestines
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/3061—Blood cells
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Biochemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Gynecology & Obstetrics (AREA)
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- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1300706.7A GB201300706D0 (en) | 2013-01-15 | 2013-01-15 | Antibody |
| GB1300706.7 | 2013-01-15 | ||
| PCT/GB2014/050104 WO2014111704A1 (en) | 2013-01-15 | 2014-01-15 | Antibodies that bind to jagged 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2897869A1 true CA2897869A1 (en) | 2014-07-24 |
Family
ID=47758013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2897869A Abandoned CA2897869A1 (en) | 2013-01-15 | 2014-01-15 | Antibodies that bind to jagged 1 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9725518B2 (enExample) |
| EP (1) | EP2945968B1 (enExample) |
| JP (1) | JP6416117B2 (enExample) |
| CA (1) | CA2897869A1 (enExample) |
| DK (1) | DK2945968T3 (enExample) |
| ES (1) | ES2724244T3 (enExample) |
| GB (1) | GB201300706D0 (enExample) |
| WO (1) | WO2014111704A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102030891B1 (ko) * | 2014-02-12 | 2019-10-11 | 제넨테크, 인크. | 항-재기드1 항체 및 사용 방법 |
| KR20170029490A (ko) | 2014-07-11 | 2017-03-15 | 제넨테크, 인크. | 노치 경로 억제 |
| PL234632B1 (pl) * | 2016-03-02 | 2020-03-31 | Inst Immunologii I Terapii Doswiadczalnej Polskiej Akademii Nauk | Przeciwciała oddziałujące z komórkami psich chłoniaków typu B i ich zastosowania |
| WO2017189705A1 (en) * | 2016-04-26 | 2017-11-02 | Temple University-Of The Commonwealth System Of Higher Education | Dll4-expressing cells and vaccine using the same |
| JOP20190259A1 (ar) * | 2017-05-31 | 2019-10-31 | Amgen Inc | بروتينات ربط مولد ضد مضادة لـ jagged1 |
| EP3438128B1 (en) * | 2017-08-04 | 2020-05-20 | Alzheimur 2012 S.L. | Anti-presenilin antibody for use in the prevention and/or treatment of cancer |
| EA039662B1 (ru) | 2017-10-03 | 2022-02-24 | Закрытое Акционерное Общество "Биокад" | Антитела, специфичные к cd47 и pd-l1 |
| US20200237909A1 (en) * | 2017-10-12 | 2020-07-30 | The Trustees Of Princeton University | Methods of treating or preventing breast cancer metastases using antibodies to jagged1 and chemotherapeutic agents |
| AU2019205279A1 (en) * | 2018-01-08 | 2020-07-30 | Susavion Biosciences, Inc. | Compositions and methods of treating cancer with glycomimetic peptides |
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| EP2155249A4 (en) | 2007-05-15 | 2011-11-16 | Oncomed Pharm Inc | COMPOSITIONS AND METHOD FOR DIAGNOSIS AND TREATMENT OF CANCER |
| US8945569B2 (en) | 2009-11-19 | 2015-02-03 | Oncomed Pharmaceuticals, Inc. | Jagged-binding agents and uses thereof |
| CA2876904C (en) * | 2012-06-22 | 2019-12-03 | Cytomx Therapeutics, Inc. | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
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2013
- 2013-01-15 GB GBGB1300706.7A patent/GB201300706D0/en not_active Ceased
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2014
- 2014-01-15 DK DK14701426.0T patent/DK2945968T3/da active
- 2014-01-15 JP JP2015553162A patent/JP6416117B2/ja not_active Expired - Fee Related
- 2014-01-15 US US14/761,062 patent/US9725518B2/en not_active Expired - Fee Related
- 2014-01-15 WO PCT/GB2014/050104 patent/WO2014111704A1/en not_active Ceased
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- 2014-01-15 ES ES14701426T patent/ES2724244T3/es active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| JP6416117B2 (ja) | 2018-10-31 |
| EP2945968A1 (en) | 2015-11-25 |
| WO2014111704A1 (en) | 2014-07-24 |
| ES2724244T3 (es) | 2019-09-09 |
| JP2016504420A (ja) | 2016-02-12 |
| DK2945968T3 (da) | 2019-05-20 |
| US20160108128A1 (en) | 2016-04-21 |
| GB201300706D0 (en) | 2013-02-27 |
| EP2945968B1 (en) | 2019-04-10 |
| US9725518B2 (en) | 2017-08-08 |
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