CA2894868C - Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif - Google Patents
Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif Download PDFInfo
- Publication number
- CA2894868C CA2894868C CA2894868A CA2894868A CA2894868C CA 2894868 C CA2894868 C CA 2894868C CA 2894868 A CA2894868 A CA 2894868A CA 2894868 A CA2894868 A CA 2894868A CA 2894868 C CA2894868 C CA 2894868C
- Authority
- CA
- Canada
- Prior art keywords
- pif
- seq
- antibodies
- antibody
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 106
- 102000004196 processed proteins & peptides Human genes 0.000 title claims description 46
- 230000004071 biological effect Effects 0.000 title description 9
- 230000009471 action Effects 0.000 title description 3
- GLXYOFXNKBTMQL-YKCHQESGSA-N (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-methylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]butanedioic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O)CCC1 GLXYOFXNKBTMQL-YKCHQESGSA-N 0.000 claims abstract description 178
- 239000000203 mixture Substances 0.000 claims abstract description 20
- 239000012530 fluid Substances 0.000 claims abstract description 12
- 210000001161 mammalian embryo Anatomy 0.000 claims description 66
- 210000004027 cell Anatomy 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 50
- 108010022347 proteolysis-inducing peptide Proteins 0.000 claims description 48
- 230000027455 binding Effects 0.000 claims description 36
- 210000002966 serum Anatomy 0.000 claims description 21
- 210000003754 fetus Anatomy 0.000 claims description 15
- 239000001963 growth medium Substances 0.000 claims description 15
- 241000124008 Mammalia Species 0.000 claims description 13
- 238000002955 isolation Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 210000004408 hybridoma Anatomy 0.000 claims description 4
- 210000004080 milk Anatomy 0.000 claims description 4
- 239000008267 milk Substances 0.000 claims description 4
- 235000013336 milk Nutrition 0.000 claims description 4
- 210000003296 saliva Anatomy 0.000 claims description 4
- 210000002700 urine Anatomy 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 description 67
- 230000035935 pregnancy Effects 0.000 description 59
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 47
- 241000282414 Homo sapiens Species 0.000 description 43
- 230000008774 maternal effect Effects 0.000 description 40
- 108090000623 proteins and genes Proteins 0.000 description 35
- 102000004127 Cytokines Human genes 0.000 description 32
- 108090000695 Cytokines Proteins 0.000 description 32
- 210000004698 lymphocyte Anatomy 0.000 description 29
- 150000001875 compounds Chemical class 0.000 description 27
- 102000005962 receptors Human genes 0.000 description 27
- 108020003175 receptors Proteins 0.000 description 27
- 102000004169 proteins and genes Human genes 0.000 description 25
- 238000003556 assay Methods 0.000 description 23
- 238000002513 implantation Methods 0.000 description 23
- 108010047620 Phytohemagglutinins Proteins 0.000 description 20
- 230000001885 phytohemagglutinin Effects 0.000 description 20
- 210000002826 placenta Anatomy 0.000 description 20
- 210000000987 immune system Anatomy 0.000 description 19
- 210000001519 tissue Anatomy 0.000 description 19
- 241000699670 Mus sp. Species 0.000 description 18
- 210000002865 immune cell Anatomy 0.000 description 17
- 230000007423 decrease Effects 0.000 description 16
- 230000004720 fertilization Effects 0.000 description 16
- 201000004792 malaria Diseases 0.000 description 16
- 108010042412 prolactin-inhibitory factor receptor Proteins 0.000 description 16
- 238000002965 ELISA Methods 0.000 description 15
- 239000000816 peptidomimetic Substances 0.000 description 15
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 14
- 210000001744 T-lymphocyte Anatomy 0.000 description 14
- 125000003275 alpha amino acid group Chemical group 0.000 description 14
- 210000002459 blastocyst Anatomy 0.000 description 14
- 210000002257 embryonic structure Anatomy 0.000 description 14
- 230000035755 proliferation Effects 0.000 description 14
- 238000000684 flow cytometry Methods 0.000 description 13
- 210000001616 monocyte Anatomy 0.000 description 13
- 230000028327 secretion Effects 0.000 description 13
- 239000000427 antigen Substances 0.000 description 12
- 230000000670 limiting effect Effects 0.000 description 12
- 102000003814 Interleukin-10 Human genes 0.000 description 11
- 108090000174 Interleukin-10 Proteins 0.000 description 11
- 102000036639 antigens Human genes 0.000 description 11
- 108091007433 antigens Proteins 0.000 description 11
- 239000012071 phase Substances 0.000 description 11
- 101710117490 Circumsporozoite protein Proteins 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 10
- 241000283973 Oryctolagus cuniculus Species 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 10
- 238000011161 development Methods 0.000 description 10
- 230000018109 developmental process Effects 0.000 description 10
- 210000002443 helper t lymphocyte Anatomy 0.000 description 10
- 230000001965 increasing effect Effects 0.000 description 10
- 239000003226 mitogen Substances 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 241000699666 Mus <mouse, genus> Species 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 9
- 229960002685 biotin Drugs 0.000 description 9
- 239000011616 biotin Substances 0.000 description 9
- 238000010790 dilution Methods 0.000 description 9
- 239000012895 dilution Substances 0.000 description 9
- 241000282412 Homo Species 0.000 description 8
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 description 8
- 239000005557 antagonist Substances 0.000 description 8
- 210000003719 b-lymphocyte Anatomy 0.000 description 8
- 238000004166 bioassay Methods 0.000 description 8
- 235000013601 eggs Nutrition 0.000 description 8
- 230000002357 endometrial effect Effects 0.000 description 8
- 239000003550 marker Substances 0.000 description 8
- 238000010186 staining Methods 0.000 description 8
- 238000012546 transfer Methods 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 210000002993 trophoblast Anatomy 0.000 description 8
- 230000035899 viability Effects 0.000 description 8
- 102100026992 Dermcidin Human genes 0.000 description 7
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 7
- 230000004913 activation Effects 0.000 description 7
- 150000001408 amides Chemical class 0.000 description 7
- 235000020958 biotin Nutrition 0.000 description 7
- 102000006495 integrins Human genes 0.000 description 7
- 108010044426 integrins Proteins 0.000 description 7
- 239000002609 medium Substances 0.000 description 7
- 238000007799 mixed lymphocyte reaction assay Methods 0.000 description 7
- 230000003169 placental effect Effects 0.000 description 7
- 241000894007 species Species 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 102100030569 Nuclear receptor corepressor 2 Human genes 0.000 description 6
- 101710153660 Nuclear receptor corepressor 2 Proteins 0.000 description 6
- 102100040247 Tumor necrosis factor Human genes 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 230000002254 contraceptive effect Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 210000004696 endometrium Anatomy 0.000 description 6
- -1 hydroxy, carboxy Chemical group 0.000 description 6
- 230000028993 immune response Effects 0.000 description 6
- 230000036039 immunity Effects 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 238000001262 western blot Methods 0.000 description 6
- 241000283690 Bos taurus Species 0.000 description 5
- 241000283707 Capra Species 0.000 description 5
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 231100000673 dose–response relationship Toxicity 0.000 description 5
- 230000002349 favourable effect Effects 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- 239000007943 implant Substances 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 210000002540 macrophage Anatomy 0.000 description 5
- 208000000995 spontaneous abortion Diseases 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 210000004291 uterus Anatomy 0.000 description 5
- 206010000234 Abortion spontaneous Diseases 0.000 description 4
- 108010002350 Interleukin-2 Proteins 0.000 description 4
- 102000000588 Interleukin-2 Human genes 0.000 description 4
- 208000006399 Premature Obstetric Labor Diseases 0.000 description 4
- 206010036600 Premature labour Diseases 0.000 description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 4
- 241000282898 Sus scrofa Species 0.000 description 4
- 239000013060 biological fluid Substances 0.000 description 4
- 229960000074 biopharmaceutical Drugs 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 210000005168 endometrial cell Anatomy 0.000 description 4
- 230000001605 fetal effect Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 230000008105 immune reaction Effects 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 208000015994 miscarriage Diseases 0.000 description 4
- 210000000822 natural killer cell Anatomy 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 244000045947 parasite Species 0.000 description 4
- 208000026440 premature labor Diseases 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 150000004492 retinoid derivatives Chemical class 0.000 description 4
- 230000001960 triggered effect Effects 0.000 description 4
- 210000004340 zona pellucida Anatomy 0.000 description 4
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 3
- 241000283073 Equus caballus Species 0.000 description 3
- 241000156978 Erebia Species 0.000 description 3
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 3
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 3
- 241000725303 Human immunodeficiency virus Species 0.000 description 3
- 102100034343 Integrase Human genes 0.000 description 3
- 102000004388 Interleukin-4 Human genes 0.000 description 3
- 108090000978 Interleukin-4 Proteins 0.000 description 3
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 241001494479 Pecora Species 0.000 description 3
- 210000000612 antigen-presenting cell Anatomy 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 230000004663 cell proliferation Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002299 complementary DNA Substances 0.000 description 3
- 239000003636 conditioned culture medium Substances 0.000 description 3
- 239000003433 contraceptive agent Substances 0.000 description 3
- 210000001771 cumulus cell Anatomy 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 210000002919 epithelial cell Anatomy 0.000 description 3
- 230000012173 estrus Effects 0.000 description 3
- 239000012091 fetal bovine serum Substances 0.000 description 3
- 230000008629 immune suppression Effects 0.000 description 3
- 230000006028 immune-suppresssive effect Effects 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- 238000004949 mass spectrometry Methods 0.000 description 3
- 230000013011 mating Effects 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 210000003101 oviduct Anatomy 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 210000005059 placental tissue Anatomy 0.000 description 3
- 230000000270 postfertilization Effects 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 238000013207 serial dilution Methods 0.000 description 3
- 230000011664 signaling Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000004936 stimulating effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 230000003558 thrombophilic effect Effects 0.000 description 3
- 102000004217 thyroid hormone receptors Human genes 0.000 description 3
- 108090000721 thyroid hormone receptors Proteins 0.000 description 3
- 230000036962 time dependent Effects 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 2
- 102100024341 10 kDa heat shock protein, mitochondrial Human genes 0.000 description 2
- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 description 2
- 102100027824 3'(2'),5'-bisphosphate nucleotidase 1 Human genes 0.000 description 2
- 102000005666 Apolipoprotein A-I Human genes 0.000 description 2
- 108010059886 Apolipoprotein A-I Proteins 0.000 description 2
- 101000606697 Aspergillus terreus (strain NIH 2624 / FGSC A1156) Probable pectin lyase F-1 Proteins 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 description 2
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 description 2
- 108010001857 Cell Surface Receptors Proteins 0.000 description 2
- 102000000844 Cell Surface Receptors Human genes 0.000 description 2
- 238000012286 ELISA Assay Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010055690 Foetal death Diseases 0.000 description 2
- 101001063392 Homo sapiens Lymphocyte function-associated antigen 3 Proteins 0.000 description 2
- 101001057324 Homo sapiens Microtubule-associated protein 1A Proteins 0.000 description 2
- 108010002352 Interleukin-1 Proteins 0.000 description 2
- 102100030984 Lymphocyte function-associated antigen 3 Human genes 0.000 description 2
- 102100027180 Microtubule-associated protein 1A Human genes 0.000 description 2
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
- 108010003541 Platelet Activating Factor Proteins 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 102100033598 Triosephosphate isomerase Human genes 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000001919 adrenal effect Effects 0.000 description 2
- 238000001042 affinity chromatography Methods 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 230000003042 antagnostic effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000007969 cellular immunity Effects 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 230000000056 copulatory effect Effects 0.000 description 2
- 210000004246 corpus luteum Anatomy 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 239000012228 culture supernatant Substances 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 108010046025 early pregnancy factor Proteins 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 230000002519 immonomodulatory effect Effects 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 208000026278 immune system disease Diseases 0.000 description 2
- 230000006058 immune tolerance Effects 0.000 description 2
- 238000003365 immunocytochemistry Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 208000021267 infertility disease Diseases 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 206010025135 lupus erythematosus Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 2
- 239000002159 nanocrystal Substances 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 239000000186 progesterone Substances 0.000 description 2
- 229960003387 progesterone Drugs 0.000 description 2
- 230000000770 proinflammatory effect Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 210000004988 splenocyte Anatomy 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 210000002536 stromal cell Anatomy 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000003390 teratogenic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000001685 thyroid gland Anatomy 0.000 description 2
- 230000001573 trophoblastic effect Effects 0.000 description 2
- 210000001215 vagina Anatomy 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 102100029444 28S ribosomal protein S10, mitochondrial Human genes 0.000 description 1
- 238000010600 3H thymidine incorporation assay Methods 0.000 description 1
- 125000003341 7 membered heterocyclic group Chemical group 0.000 description 1
- 102100029325 ATP-dependent DNA helicase PIF1 Human genes 0.000 description 1
- 241000199898 Alaria <Phaeophyceae> Species 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 101100288313 Arabidopsis thaliana KTI4 gene Proteins 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 101001125884 Autographa californica nuclear polyhedrosis virus Per os infectivity factor 1 Proteins 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- GXGJIOMUZAGVEH-UHFFFAOYSA-N Chamazulene Chemical group CCC1=CC=C(C)C2=CC=C(C)C2=C1 GXGJIOMUZAGVEH-UHFFFAOYSA-N 0.000 description 1
- 102000008169 Co-Repressor Proteins Human genes 0.000 description 1
- 108010060434 Co-Repressor Proteins Proteins 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 206010061452 Complication of pregnancy Diseases 0.000 description 1
- 102100039077 Cytosolic 10-formyltetrahydrofolate dehydrogenase Human genes 0.000 description 1
- 150000008574 D-amino acids Chemical class 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 206010052804 Drug tolerance Diseases 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 102100025137 Early activation antigen CD69 Human genes 0.000 description 1
- 102100031804 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial Human genes 0.000 description 1
- 108010069915 Electron-transferring-flavoprotein dehydrogenase Proteins 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241001331845 Equus asinus x caballus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102100033299 Glia-derived nexin Human genes 0.000 description 1
- 102000006771 Gonadotropins Human genes 0.000 description 1
- 108010086677 Gonadotropins Proteins 0.000 description 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 102100021519 Hemoglobin subunit beta Human genes 0.000 description 1
- 108091005904 Hemoglobin subunit beta Proteins 0.000 description 1
- 101000699882 Homo sapiens 28S ribosomal protein S10, mitochondrial Proteins 0.000 description 1
- 101001125842 Homo sapiens ATP-dependent DNA helicase PIF1 Proteins 0.000 description 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 description 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 1
- 101000578830 Homo sapiens Methionine aminopeptidase 1 Proteins 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 102000008607 Integrin beta3 Human genes 0.000 description 1
- 108010020950 Integrin beta3 Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102000004890 Interleukin-8 Human genes 0.000 description 1
- 108090001007 Interleukin-8 Proteins 0.000 description 1
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
- 150000008575 L-amino acids Chemical class 0.000 description 1
- 208000035752 Live birth Diseases 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 108010020004 Microtubule-Associated Proteins Proteins 0.000 description 1
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 description 1
- 101100403102 Mus musculus Mucl2 gene Proteins 0.000 description 1
- 230000006051 NK cell activation Effects 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 240000008881 Oenanthe javanica Species 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 206010036595 Premature delivery Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 108090000928 Ribosomal protein S10 Proteins 0.000 description 1
- 102000004394 Ribosomal protein S10 Human genes 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 108700012920 TNF Proteins 0.000 description 1
- 101150033985 TPI gene Proteins 0.000 description 1
- 101150032817 TPI1 gene Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 206010052779 Transplant rejections Diseases 0.000 description 1
- 108700015934 Triose-phosphate isomerases Proteins 0.000 description 1
- 101710194411 Triosephosphate isomerase 1 Proteins 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000007503 antigenic stimulation Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000011948 assay development Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 238000007413 biotinylation Methods 0.000 description 1
- 230000006287 biotinylation Effects 0.000 description 1
- 230000029803 blastocyst development Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 208000015294 blood coagulation disease Diseases 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 210000004081 cilia Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000009852 coagulant defect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000000562 conjugate Substances 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 230000032692 embryo implantation Effects 0.000 description 1
- 210000002308 embryonic cell Anatomy 0.000 description 1
- 230000009088 enzymatic function Effects 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 230000008217 follicular development Effects 0.000 description 1
- 210000001733 follicular fluid Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 125000003838 furazanyl group Chemical group 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 108010051015 glutathione-independent formaldehyde dehydrogenase Proteins 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 239000000122 growth hormone Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 125000002632 imidazolidinyl group Chemical group 0.000 description 1
- 125000002636 imidazolinyl group Chemical group 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000008073 immune recognition Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 238000012308 immunohistochemistry method Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000009027 insemination Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 230000008316 intracellular mechanism Effects 0.000 description 1
- 238000010212 intracellular staining Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 229960003299 ketamine Drugs 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007108 local immune response Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 230000002297 mitogenic effect Effects 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
- 108091005601 modified peptides Proteins 0.000 description 1
- 230000000051 modifying effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000863 peptide conjugate Substances 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 230000003836 peripheral circulation Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000005936 piperidyl group Chemical group 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 208000012113 pregnancy disease Diseases 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000007112 pro inflammatory response Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 150000003147 proline derivatives Chemical class 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 230000004850 protein–protein interaction Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 description 1
- 125000002755 pyrazolinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229940126586 small molecule drug Drugs 0.000 description 1
- 229940036051 sojourn Drugs 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 108010004034 stable plasma protein solution Proteins 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000006277 sulfonation reaction Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 125000005505 thiomorpholino group Chemical group 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 210000000251 trophoblastic cell Anatomy 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
- 229960001600 xylazine Drugs 0.000 description 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Une composition destinée à détecter la présence dun peptide de facteur de préimplantation (PIF) dans un fluide, la composition comprenant des anticorps PIF et ledit fluide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2985469A CA2985469A1 (fr) | 2003-10-22 | 2004-10-22 | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51337003P | 2003-10-22 | 2003-10-22 | |
| US60/513,370 | 2003-10-22 | ||
| US48224403A | 2003-12-22 | 2003-12-22 | |
| US10/482,244 | 2003-12-22 | ||
| CA2584690A CA2584690C (fr) | 2003-10-22 | 2004-10-22 | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2584690A Division CA2584690C (fr) | 2003-10-22 | 2004-10-22 | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2985469A Division CA2985469A1 (fr) | 2003-10-22 | 2004-10-22 | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2894868A1 CA2894868A1 (fr) | 2005-05-06 |
| CA2894868C true CA2894868C (fr) | 2017-12-12 |
Family
ID=45349626
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2985469A Abandoned CA2985469A1 (fr) | 2003-10-22 | 2004-10-22 | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif |
| CA2894868A Expired - Fee Related CA2894868C (fr) | 2003-10-22 | 2004-10-22 | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2985469A Abandoned CA2985469A1 (fr) | 2003-10-22 | 2004-10-22 | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif |
Country Status (2)
| Country | Link |
|---|---|
| CA (2) | CA2985469A1 (fr) |
| NZ (1) | NZ578577A (fr) |
-
2004
- 2004-10-22 CA CA2985469A patent/CA2985469A1/fr not_active Abandoned
- 2004-10-22 CA CA2894868A patent/CA2894868C/fr not_active Expired - Fee Related
- 2004-10-22 NZ NZ578577A patent/NZ578577A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2894868A1 (fr) | 2005-05-06 |
| CA2985469A1 (fr) | 2005-05-06 |
| NZ578577A (en) | 2011-12-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7723289B2 (en) | PIF tetrapeptides | |
| IL175063A (en) | Use of pif peptides in the manufacture of a medicament for treating intolerance to embryo implantation | |
| CA3167498A1 (fr) | Groupes d'epitopes de lymphocytes t et compositions associees utiles dans la prevention, le diagnostic et le traitement de la covid-19 | |
| US20190054139A1 (en) | Compositions and methods for modulating the immune system | |
| KR102158225B1 (ko) | 헬퍼 t세포의 활성화 방법 | |
| US8222211B2 (en) | Methods of administering PIF agonist peptides and uses thereof | |
| AU2019203459A1 (en) | PIF binding as a marker for immune dysregulation | |
| JP2005512953A (ja) | 着床前因子の新しいアッセイ方法および着床前因子ペプチド | |
| CA2894868C (fr) | Activites biologiques de peptides pif, site d'action, et anticorps pour detecter pif | |
| US20230013244A1 (en) | Pif binding as a marker for immune dysregulation | |
| EP1680442B1 (fr) | Activites biologiques de peptides pif | |
| Kling et al. | Experience with Allogeneic Leukocyte Immunization (Ai) for Implantation Failure in the In‐Vitro Fertilization Program | |
| Kamada et al. | Specific cytotoxicity of antibody to YAL-198, a sperm antigen peptide, to murine zygote | |
| Blois et al. | Therapy with Dendritic Cells (DCs) control fetal abortion rate in the CBA/J× DBA/2J mouse model | |
| Zenclussen et al. | Increased expression of chemokine receptor 5 (CCR5) in blood and decidual cells in a mouse model for preeclampsia (PE) | |
| Lidström et al. | Suppressor macrophages in early pregnancy human decidua | |
| Fernekorn et al. | Regulation of leukocyte recruitment to the murine maternal/fetal interface by specialized patterns of vascular adhesion receptors | |
| Uthoff et al. | The impact of maternal allergic sensitization on the development of pre‐and postnatal immunity | |
| Fitzgerald et al. | Is Stat3 activation in trophoblast cells required for invasiveness? | |
| Hammadeh et al. | Relationship between cytokine concentration in serum, pre‐ovulatory follicular fluid and icsi outcome | |
| Koc et al. | Enhancement of immunogenicity of JEG‐3 Cells by ectopic expression of HLA‐A* 0201 and CD80 | |
| Jerzak et al. | Extracellular matrix proteins dependent apoptosis of T Cells in women with a history of recurrent spontaneous abortion | |
| Abram et al. | Systemic cytokine response during listeria monocytogenes infection in pregnant BALB/C Mice | |
| Jonáková et al. | Mutual interactions of boar seminal plasma proteins studied by immunological and chromatographic methods | |
| Jonsson et al. | Cytokine profile in women with preeclampsia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150618 |
|
| MKLA | Lapsed |
Effective date: 20221024 |