CA2882437C - Method of adjuvant cancer treatment - Google Patents

Method of adjuvant cancer treatment Download PDF

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Publication number
CA2882437C
CA2882437C CA2882437A CA2882437A CA2882437C CA 2882437 C CA2882437 C CA 2882437C CA 2882437 A CA2882437 A CA 2882437A CA 2882437 A CA2882437 A CA 2882437A CA 2882437 C CA2882437 C CA 2882437C
Authority
CA
Canada
Prior art keywords
dabrafenib
trametinib
melanoma
patient
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2882437A
Other languages
English (en)
French (fr)
Other versions
CA2882437A1 (en
Inventor
Sylvie Laquerre
Peter F. Lebowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50237545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2882437(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CA2882437A1 publication Critical patent/CA2882437A1/en
Application granted granted Critical
Publication of CA2882437C publication Critical patent/CA2882437C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
CA2882437A 2012-09-04 2013-08-30 Method of adjuvant cancer treatment Active CA2882437C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261696375P 2012-09-04 2012-09-04
US61/696,375 2012-09-04
PCT/US2013/057432 WO2014039375A1 (en) 2012-09-04 2013-08-30 Method of adjuvant cancer treatment

Publications (2)

Publication Number Publication Date
CA2882437A1 CA2882437A1 (en) 2014-03-13
CA2882437C true CA2882437C (en) 2021-03-02

Family

ID=50237545

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2882437A Active CA2882437C (en) 2012-09-04 2013-08-30 Method of adjuvant cancer treatment

Country Status (20)

Country Link
US (6) US20150216868A1 (https=)
EP (2) EP2892535B1 (https=)
JP (3) JP2015527374A (https=)
KR (1) KR102134585B1 (https=)
CN (2) CN104582706A (https=)
AU (2) AU2013313050A1 (https=)
BR (1) BR112015004578A2 (https=)
CA (1) CA2882437C (https=)
CY (1) CY1124812T1 (https=)
DK (1) DK2892535T3 (https=)
ES (1) ES2900825T3 (https=)
HR (1) HRP20211817T1 (https=)
HU (1) HUE056646T2 (https=)
IN (1) IN2015KN00449A (https=)
LT (1) LT2892535T (https=)
PL (1) PL2892535T3 (https=)
PT (1) PT2892535T (https=)
RU (1) RU2640180C2 (https=)
SI (1) SI2892535T1 (https=)
WO (1) WO2014039375A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2015KN00449A (https=) 2012-09-04 2015-07-17 Glaxosmithkline Llc
ES2660989T3 (es) 2013-12-28 2018-03-27 Guardant Health, Inc. Métodos y sistemas para detectar variantes genéticas
AU2017329090B9 (en) 2016-09-19 2019-09-05 Novartis Ag Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor
ES2952265T3 (es) * 2017-05-02 2023-10-30 Novartis Ag Terapia combinada que comprende un inhibidor de Raf y trametinib
WO2019204399A1 (en) * 2018-04-17 2019-10-24 The University Of Chicago Methods and compositions for treating cancer
CN109106893B (zh) * 2018-11-12 2021-04-20 上海市中西医结合医院 一种调节肠道屏障功能的中药复方制剂及其制备方法
ES3025633T3 (en) 2019-05-13 2025-06-09 Novartis Ag New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
CN114981298B (zh) * 2019-12-12 2024-08-20 听治疗有限责任公司 用于预防和治疗听力损失的组合物和方法
US20250032494A1 (en) 2021-12-06 2025-01-30 My Personal Therapeutics Ltd A combination treatment for cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005252110B2 (en) * 2004-06-11 2008-09-04 Shionogi & Co., Ltd. 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido[2,3-D] pyrimidine derivatives and related compounds for the treatment of cancer
SI1853250T1 (sl) * 2005-02-18 2012-01-31 Abraxis Bioscience Llc Kombinacije in reĹľimi dajanja terapevtskih sredstev in kombinirana terapija
UA103319C2 (en) * 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
US8703781B2 (en) * 2009-10-16 2014-04-22 Glaxosmithkline Llc Pharmaceutical combination of MEK inhibitor and B-RAF inhibitors
US20130004481A1 (en) 2011-01-12 2013-01-03 Boehringer Ingelheim International Gmbh Anticancer therapy
IN2015KN00449A (https=) 2012-09-04 2015-07-17 Glaxosmithkline Llc

Also Published As

Publication number Publication date
JP2015527374A (ja) 2015-09-17
JP6684941B2 (ja) 2020-04-22
EP2892535A4 (en) 2016-04-13
US20230330091A1 (en) 2023-10-19
EP3981408A1 (en) 2022-04-13
US20200054641A1 (en) 2020-02-20
CA2882437A1 (en) 2014-03-13
PT2892535T (pt) 2021-12-15
AU2013313050A1 (en) 2015-03-26
JP2019142899A (ja) 2019-08-29
HK1206642A1 (en) 2016-01-15
EP2892535B1 (en) 2021-09-22
DK2892535T3 (da) 2022-01-03
EP2892535A1 (en) 2015-07-15
RU2640180C2 (ru) 2017-12-26
WO2014039375A1 (en) 2014-03-13
KR20150047619A (ko) 2015-05-04
CY1124812T1 (el) 2022-11-25
HUE056646T2 (hu) 2022-02-28
US20180338979A1 (en) 2018-11-29
US20150216868A1 (en) 2015-08-06
US20170202842A1 (en) 2017-07-20
US20210060021A1 (en) 2021-03-04
PL2892535T3 (pl) 2022-01-31
CN104582706A (zh) 2015-04-29
AU2016244279A1 (en) 2016-11-03
JP6511117B2 (ja) 2019-05-15
US10869869B2 (en) 2020-12-22
HRP20211817T1 (hr) 2022-03-04
LT2892535T (lt) 2021-12-10
RU2015105821A (ru) 2016-10-20
KR102134585B1 (ko) 2020-07-17
JP2018058859A (ja) 2018-04-12
SI2892535T1 (sl) 2022-01-31
AU2016244279B2 (en) 2018-01-04
BR112015004578A2 (pt) 2017-07-04
CN107308164A (zh) 2017-11-03
IN2015KN00449A (https=) 2015-07-17
ES2900825T3 (es) 2022-03-18

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