CA2878734C - Inhibition selective du complexe d'attaque membranaire du complement et de la c3 convertase par des composants a faible poids moleculaire du complexe synthetique d'acide pararosol ique tricarboxylique - Google Patents
Inhibition selective du complexe d'attaque membranaire du complement et de la c3 convertase par des composants a faible poids moleculaire du complexe synthetique d'acide pararosol ique tricarboxylique Download PDFInfo
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- CA2878734C CA2878734C CA2878734A CA2878734A CA2878734C CA 2878734 C CA2878734 C CA 2878734C CA 2878734 A CA2878734 A CA 2878734A CA 2878734 A CA2878734 A CA 2878734A CA 2878734 C CA2878734 C CA 2878734C
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- complement
- convertase
- membrane attack
- complex
- aurin
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Abstract
L'invention concerne l'inhibition sélective du complexe d'attaque membranaire du complément chez une espèce de mammifère, de préférence un être humain, par des composants du complexe acide pararosolique tricarboxylique inférieur à 1 kilodalton en poids moléculaire. Les inhibiteurs préférés sont l'acide pararosolique tricarboxylique, l'acide pararosolique quadracarboxylique et l'acide pararosolique hexacarboxylique. La maladie à traiter de préférence par l'inhibition élective du complexe d'attaque membranaire du complément est la dégénérescence maculaire liée à l'âge, la maladie d'Alzheimer, l'athérosclérose, la polyarthrite rhumatoïde, l'hémoglobinémie paroxystique nocturne, l'infection par la malaria et la sclérose en plaques.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2012/053608 WO2014009779A1 (fr) | 2012-07-13 | 2012-07-13 | Inhibition sélective du complexe d'attaque membranaire du complément et de la c3 convertase par des composants à faible poids moléculaire du complexe synthétique d'acide pararosolique tricarboxylique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2878734A1 CA2878734A1 (fr) | 2014-01-16 |
| CA2878734C true CA2878734C (fr) | 2021-04-27 |
Family
ID=49915467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2878734A Expired - Fee Related CA2878734C (fr) | 2012-07-13 | 2012-07-13 | Inhibition selective du complexe d'attaque membranaire du complement et de la c3 convertase par des composants a faible poids moleculaire du complexe synthetique d'acide pararosol ique tricarboxylique |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2872130A4 (fr) |
| JP (1) | JP2015522060A (fr) |
| CN (1) | CN104661660A (fr) |
| CA (1) | CA2878734C (fr) |
| WO (1) | WO2014009779A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8877808B2 (en) * | 2012-12-06 | 2014-11-04 | Aurin Biotech Inc. | Protection against skin diseases by aurin tricarboxylic acid and its derivatives |
| WO2015070354A1 (fr) | 2013-11-18 | 2015-05-21 | Aurin Biotech Inc. | Dimères de l'acide acétylsalicylique, leur synthèse, et leurs utilisations pour prévenir et traiter des troubles médiés par le complément |
| JP2020521723A (ja) * | 2017-05-31 | 2020-07-27 | オーリン バイオテック インコーポレイテッドＡｕｒｉｎ Ｂｉｏｔｅｃｈ Ｉｎｃ． | 悪液質の診断方法および治療方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4007270A (en) * | 1975-11-18 | 1977-02-08 | American Cyanamid Company | Complement inhibitors |
| US5434185A (en) * | 1993-05-17 | 1995-07-18 | The University Of Kentucky Research Foundation | Method for inhibiting angiogenesis with aurintricarboxylic acid, its analogues or salts |
| AU2001234730A1 (en) * | 2000-02-01 | 2001-08-14 | Beth Israel Deaconess Medical Center | Method for inhibiting complement activation |
| JP2009516751A (ja) * | 2005-11-21 | 2009-04-23 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティー・オブ・アラバマ・フォー・アンド・オン・ビハーフ・オブ・ザ・ユニバーシティー・オブ・アラバマ | 神経保護のための小分子化合物を使用する方法 |
| CA2631071A1 (fr) * | 2008-05-09 | 2009-11-09 | Tong-Jun Lin | Inhibition des calpaines reduisant l'inflammation allergique |
| WO2010042728A1 (fr) * | 2008-10-08 | 2010-04-15 | Cornell University | Modulateurs à petite molécule d'une absorption de prongf |
| US20130035392A1 (en) * | 2011-08-01 | 2013-02-07 | Mcgeer Patrick L | Selective inhibition of the membrane attack complex of complement and C3 convertase by low molecular weight components of the aurin tricarboxylic acid synthetic complex |
| US10966945B2 (en) * | 2011-08-01 | 2021-04-06 | Aurin Biotech Inc. | Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic synthetic complex |
-
2012
- 2012-07-13 EP EP12880850.8A patent/EP2872130A4/fr not_active Withdrawn
- 2012-07-13 CN CN201280075715.2A patent/CN104661660A/zh active Pending
- 2012-07-13 JP JP2015521077A patent/JP2015522060A/ja active Pending
- 2012-07-13 WO PCT/IB2012/053608 patent/WO2014009779A1/fr active Application Filing
- 2012-07-13 CA CA2878734A patent/CA2878734C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2878734A1 (fr) | 2014-01-16 |
| JP2015522060A (ja) | 2015-08-03 |
| EP2872130A1 (fr) | 2015-05-20 |
| EP2872130A4 (fr) | 2016-06-22 |
| CN104661660A (zh) | 2015-05-27 |
| WO2014009779A1 (fr) | 2014-01-16 |
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