CA2878695A1 - Method of treating type i diabetes using apolipoprotein aiv - Google Patents

Method of treating type i diabetes using apolipoprotein aiv Download PDF

Info

Publication number
CA2878695A1
CA2878695A1 CA2878695A CA2878695A CA2878695A1 CA 2878695 A1 CA2878695 A1 CA 2878695A1 CA 2878695 A CA2878695 A CA 2878695A CA 2878695 A CA2878695 A CA 2878695A CA 2878695 A1 CA2878695 A1 CA 2878695A1
Authority
CA
Canada
Prior art keywords
apolipoprotein
apoa
biologically active
active analogue
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2878695A
Other languages
English (en)
French (fr)
Inventor
Patrick Tso
Xiaoming Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Cincinnati
Original Assignee
University of Cincinnati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Cincinnati filed Critical University of Cincinnati
Publication of CA2878695A1 publication Critical patent/CA2878695A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CA2878695A 2012-07-25 2013-07-25 Method of treating type i diabetes using apolipoprotein aiv Abandoned CA2878695A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261675659P 2012-07-25 2012-07-25
US61/675,659 2012-07-25
PCT/US2013/052078 WO2014018763A2 (en) 2012-07-25 2013-07-25 Method of treating type i diabetes using apolipoprotein aiv

Publications (1)

Publication Number Publication Date
CA2878695A1 true CA2878695A1 (en) 2014-01-30

Family

ID=48916270

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2878695A Abandoned CA2878695A1 (en) 2012-07-25 2013-07-25 Method of treating type i diabetes using apolipoprotein aiv

Country Status (6)

Country Link
US (1) US9730980B2 (enExample)
EP (1) EP2877197A2 (enExample)
JP (1) JP2015524808A (enExample)
AU (1) AU2013295721B2 (enExample)
CA (1) CA2878695A1 (enExample)
WO (1) WO2014018763A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX342020B (es) 2011-01-19 2016-09-08 Univ Cincinnati Apolipoproteina a-iv como un peptido antidiabetico.
HK1203823A1 (en) 2012-01-19 2015-11-06 University Of Cincinnati Method of treating diabetes using non-glycosylated apolipoprotein a-iv
WO2014018079A1 (en) 2012-07-25 2014-01-30 University Of Cincinnati Method of treating hyperglycemic disorders using apoliprotein aiv

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
FR2686605B1 (fr) 1992-01-27 1994-03-11 Rhone Poulenc Rorer Sa Nouveaux polypeptides, leur preparation et leur utilisation.
AU7242394A (en) 1993-05-28 1994-12-20 Merck & Co., Inc. Method to control appetite and treat obesity
CA2453653A1 (en) * 2001-07-26 2003-02-06 Genset S.A. Gmg-2 polynucleotides and polypeptides and uses thereof
IL161233A0 (en) * 2001-10-05 2004-09-27 Genset Sa Fragments of the polypeptide gzip and their use in obesity
NZ537006A (en) 2002-05-17 2008-01-31 Esperion Therapeutics Inc The use of apolipoprotein A-I Milano, for the manufacture ofa composition for treating preventing or reducing ischemic reperfusion injury in a tissue or organ
RU2006134701A (ru) * 2004-03-01 2008-04-10 Пептиммьюн Способы и композиции для лечения аутоиммунных заболеваний
TW200815377A (en) * 2006-04-24 2008-04-01 Astellas Pharma Inc Oxadiazolidinedione compound
US20100267052A1 (en) 2006-09-01 2010-10-21 American Type Culture Collection Compositions and methods for diagnosis and treatment of type 2 diabetes
EP2257814B1 (en) 2008-03-21 2012-08-29 Podiceps B.v. Diagnostic of pre-symptomatic metabolic syndrome
CN101747305B (zh) 2008-11-28 2014-06-18 中国医学科学院药物研究所 硝克柳胺化合物晶v型、其制法和其药物组合物与用途
DK2498802T3 (en) * 2009-11-13 2015-04-13 Sanofi Aventis Deutschland Pharmaceutical composition comprising a GLP-1 agonist, insulin and a methionine
MX342020B (es) * 2011-01-19 2016-09-08 Univ Cincinnati Apolipoproteina a-iv como un peptido antidiabetico.
HK1203823A1 (en) 2012-01-19 2015-11-06 University Of Cincinnati Method of treating diabetes using non-glycosylated apolipoprotein a-iv
WO2014018079A1 (en) 2012-07-25 2014-01-30 University Of Cincinnati Method of treating hyperglycemic disorders using apoliprotein aiv

Also Published As

Publication number Publication date
US9730980B2 (en) 2017-08-15
JP2015524808A (ja) 2015-08-27
WO2014018763A3 (en) 2014-03-20
AU2013295721B2 (en) 2017-07-20
AU2013295721A1 (en) 2015-02-05
WO2014018763A2 (en) 2014-01-30
US20150164986A1 (en) 2015-06-18
EP2877197A2 (en) 2015-06-03

Similar Documents

Publication Publication Date Title
Pereira et al. Tissue-specific effects of leptin on glucose and lipid metabolism
Dogra et al. TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine
US20240207207A1 (en) Methods for mitigating and preventing proteostasis-based injuries
AU2012366182B2 (en) Method of treating diabetes using non-glycosylated apolipoprotein A-IV
US9730980B2 (en) Method of treating type I diabetes using apolipoprotein A-IV
CA3065816C (en) TREATMENT OF HEART DISEASE BY INHIBITION OF THE ACTION OF MUSCLE PROTEIN-ANCHORING PROTEINS KINASES A (MAKAP)
KR20230159847A (ko) 염증성 또는 활성화된 세포를 표적으로 하고 염증성 상태 및 통증을 치료 또는 개선하기 위한 조성물 및 방법
WO2006096816A2 (en) Human leptin-derived polypeptides and uses thereof
US20220195398A1 (en) Abhd5 and partial hdac4 fragments and variants as a therapeutic approach for the treatment of cardiovascular diseases
AU2012385960B2 (en) Method of treating hyperglycemic disorders using apolipoprotein AIV
US20070218504A1 (en) Human leptin-derived polypeptides and uses thereof
CA2493859C (en) Preventive/remedy for arteriosclerosis comprising adiponectin
CN104511028B (zh) Klf9基因在抑制肝癌中的应用
US20260124275A1 (en) Methods of treating diabetes and related complications
US8569232B2 (en) Therapeutic agent for diabetes
US20170326208A1 (en) Treatment of diseases asssociated with fat accumulation
US20230173029A1 (en) Treatment of cardiac remodelling
JP2011219375A (ja) オルニチンアミノトランスフェラーゼ酵素活性阻害剤の使用
Ota Acylation Stimulating Protein

Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20190725