CA2878370A1 - Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire - Google Patents

Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire Download PDF

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Publication number
CA2878370A1
CA2878370A1 CA2878370A CA2878370A CA2878370A1 CA 2878370 A1 CA2878370 A1 CA 2878370A1 CA 2878370 A CA2878370 A CA 2878370A CA 2878370 A CA2878370 A CA 2878370A CA 2878370 A1 CA2878370 A1 CA 2878370A1
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Prior art keywords
preventive
intraocular pressure
present compound
glaucoma
pressure lowering
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CA2878370A
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CA2878370C (fr
Inventor
Tomoko Kirihara
Atsushi Shimazaki
Masatsugu Nakamura
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Santen Pharmaceutical Co Ltd
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Santen Pharmaceutical Co Ltd
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Priority to CA3099517A priority Critical patent/CA3099517C/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une combinaison de médicaments pour la prévention ou le traitement du glaucome ou de l'hypertension oculaire, ladite combinaison étant utile en tant qu'agent de prévention ou de traitement du glaucome ou de l'hypertension oculaire. Les effets de réduction de la tension oculaire peuvent être complétés et/ou améliorés par la combinaison de (6-{[4-(pyrazole-1-yl)benzyl] (pyridin-3-ylsulfonyl)aminométhyl} pyridine-2-ylamino) de l'acétate d'isopropyle et d'autres médicaments pour la prévention ou le traitement du glaucome ou de l'hypertension oculaire. Les médicaments peuvent être administrés en forme d'administration combinée ou d'un mélange.
CA2878370A 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire Active CA2878370C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3099517A CA3099517C (fr) 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012-157204 2012-07-13
JP2012157204 2012-07-13
PCT/JP2013/068927 WO2014010654A2 (fr) 2012-07-13 2013-07-11 Combinaison de composés de sulfonamide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3099517A Division CA3099517C (fr) 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire

Publications (2)

Publication Number Publication Date
CA2878370A1 true CA2878370A1 (fr) 2014-01-16
CA2878370C CA2878370C (fr) 2021-01-19

Family

ID=49916622

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3099517A Active CA3099517C (fr) 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire
CA2878370A Active CA2878370C (fr) 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA3099517A Active CA3099517C (fr) 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire

Country Status (6)

Country Link
JP (3) JP6193655B2 (fr)
KR (1) KR102074020B1 (fr)
CA (2) CA3099517C (fr)
PH (1) PH12015500025A1 (fr)
TW (1) TWI643619B (fr)
WO (1) WO2014010654A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10149908B2 (en) 2014-01-10 2018-12-11 Santen Pharmaceutical Co., Ltd. Pharmaceutical composition containing pyridylaminoacetic acid compound

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Publication number Priority date Publication date Assignee Title
CA3099517C (fr) * 2012-07-13 2022-04-26 Santen Pharmaceutical Co., Ltd. Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire
UA117506C2 (uk) 2014-01-10 2018-08-10 Сантен Фармас'Ютікал Ко., Лтд. Фармацевтичний препарат, який містить сполуку піридиламінооцтової кислоти
KR101858373B1 (ko) * 2014-01-10 2018-05-15 산텐 세이야꾸 가부시키가이샤 피리딜아미노아세트산 화합물과 폴리옥시에틸렌 피마자유를 함유하는 의약 조성물
JP6236166B2 (ja) * 2014-09-25 2017-11-22 興和株式会社 水性組成物
AR105215A1 (es) * 2015-07-01 2017-09-13 Santen Pharmaceutical Co Ltd Formulación de depósito que contiene ésteres de ácido cítrico
ES2950461T3 (es) * 2015-07-09 2023-10-10 Santen Pharmaceutical Co Ltd Agente preventivo y/o terapéutico que contiene un compuesto de ácido piridilaminoacético para el tratamiento de una enfermedad que involucra una presión intraocular muy elevada
RU2745317C2 (ru) * 2016-02-22 2021-03-23 Сантен Фармасьютикал Ко., Лтд. Фармацевтическая композиция, включающая дорзоламид и бримонидин
US20200121652A1 (en) 2017-06-16 2020-04-23 The Doshisha Compounds having caspase inhibitory activity, pharmaceutical agent containing said compounds and for treating or preventing corneal endothelial symptoms, disorders, or diseases, and application of said pharmaceutical agent
KR102619458B1 (ko) 2017-06-16 2023-12-29 학교법인 도시샤 mTOR 인히비터를 포함하는, 눈의 증상, 장해 또는 질환을 치료 또는 예방하기 위한 의약 및 그 응용
WO2019124489A1 (fr) * 2017-12-21 2019-06-27 参天製薬株式会社 Médicament comprenant une combinaison de sépétaprost et d'agoniste d'ep2
US20210106569A1 (en) * 2017-12-21 2021-04-15 Santen Pharmaceutical Co., Ltd. Omidenepag combination
JP7346305B2 (ja) * 2017-12-28 2023-09-19 参天製薬株式会社 ピリジルアミノ酢酸化合物を含有する医薬製剤
JP2020033290A (ja) * 2018-08-29 2020-03-05 興和株式会社 水性組成物
US11608319B2 (en) 2019-12-31 2023-03-21 Industrial Technology Research Institute Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase

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JP2007119388A (ja) * 2005-10-27 2007-05-17 Ono Pharmaceut Co Ltd Ｅｐ２アゴニストと血管収縮薬を組み合わせてなる安全性の高い緑内障治療剤
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CA3099517C (fr) * 2012-07-13 2022-04-26 Santen Pharmaceutical Co., Ltd. Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire

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Publication number Priority date Publication date Assignee Title
US10149908B2 (en) 2014-01-10 2018-12-11 Santen Pharmaceutical Co., Ltd. Pharmaceutical composition containing pyridylaminoacetic acid compound
US10485872B2 (en) 2014-01-10 2019-11-26 Santen Pharmaceutical Co., Ltd. Pharmaceutical composition containing pyridylaminoacetic acid compound
US10765750B2 (en) 2014-01-10 2020-09-08 Santen Pharmaceutical Co., Ltd. Pharmaceutical composition containing pyridylaminoacetic acid compound

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JP6383058B2 (ja) 2018-08-29
JP6667583B2 (ja) 2020-03-18
JP2017186375A (ja) 2017-10-12
WO2014010654A2 (fr) 2014-01-16
JP2014031369A (ja) 2014-02-20
JP6193655B2 (ja) 2017-09-06
TW201408297A (zh) 2014-03-01
CA3099517A1 (fr) 2014-01-16
KR20150036320A (ko) 2015-04-07
TWI643619B (zh) 2018-12-11
WO2014010654A3 (fr) 2014-03-06
CA2878370C (fr) 2021-01-19
JP2018165285A (ja) 2018-10-25
PH12015500025B1 (en) 2015-02-23
PH12015500025A1 (en) 2015-02-23
KR102074020B1 (ko) 2020-02-05
CA3099517C (fr) 2022-04-26

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