CA2878370A1 - Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire - Google Patents

Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire Download PDF

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Publication number
CA2878370A1
CA2878370A1 CA2878370A CA2878370A CA2878370A1 CA 2878370 A1 CA2878370 A1 CA 2878370A1 CA 2878370 A CA2878370 A CA 2878370A CA 2878370 A CA2878370 A CA 2878370A CA 2878370 A1 CA2878370 A1 CA 2878370A1
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Prior art keywords
preventive
intraocular pressure
present compound
glaucoma
pressure lowering
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CA2878370A
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CA2878370C (fr
Inventor
Tomoko Kirihara
Atsushi Shimazaki
Masatsugu Nakamura
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Santen Pharmaceutical Co Ltd
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Santen Pharmaceutical Co Ltd
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Priority to CA3099517A priority Critical patent/CA3099517C/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une combinaison de médicaments pour la prévention ou le traitement du glaucome ou de l'hypertension oculaire, ladite combinaison étant utile en tant qu'agent de prévention ou de traitement du glaucome ou de l'hypertension oculaire. Les effets de réduction de la tension oculaire peuvent être complétés et/ou améliorés par la combinaison de (6-{[4-(pyrazole-1-yl)benzyl] (pyridin-3-ylsulfonyl)aminométhyl} pyridine-2-ylamino) de l'acétate d'isopropyle et d'autres médicaments pour la prévention ou le traitement du glaucome ou de l'hypertension oculaire. Les médicaments peuvent être administrés en forme d'administration combinée ou d'un mélange.
CA2878370A 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire Active CA2878370C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3099517A CA3099517C (fr) 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012-157204 2012-07-13
JP2012157204 2012-07-13
PCT/JP2013/068927 WO2014010654A2 (fr) 2012-07-13 2013-07-11 Combinaison de composés de sulfonamide

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3099517A Division CA3099517C (fr) 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire

Publications (2)

Publication Number Publication Date
CA2878370A1 true CA2878370A1 (fr) 2014-01-16
CA2878370C CA2878370C (fr) 2021-01-19

Family

ID=49916622

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3099517A Active CA3099517C (fr) 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire
CA2878370A Active CA2878370C (fr) 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA3099517A Active CA3099517C (fr) 2012-07-13 2013-07-11 Combinaison de composes de sulfonamide aux fins de traitement d'un glaucome ou d'une hypertension oculaire

Country Status (6)

Country Link
JP (3) JP6193655B2 (fr)
KR (1) KR102074020B1 (fr)
CA (2) CA3099517C (fr)
PH (1) PH12015500025B1 (fr)
TW (1) TWI643619B (fr)
WO (1) WO2014010654A2 (fr)

Cited By (1)

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US10149908B2 (en) 2014-01-10 2018-12-11 Santen Pharmaceutical Co., Ltd. Pharmaceutical composition containing pyridylaminoacetic acid compound

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KR102074020B1 (ko) * 2012-07-13 2020-02-05 산텐 세이야꾸 가부시키가이샤 술폰아미드 화합물의 조합
GEP20186916B (en) * 2014-01-10 2018-11-12 Pharmaceutical Co Ltd Santen Pyridylaminoacetic acid compound and polyoxyethylene castor oil-containing pharmaceutical composition
KR101824829B1 (ko) 2014-01-10 2018-02-01 산텐 세이야꾸 가부시키가이샤 피리딜아미노아세트산 화합물을 포함하는 의약 제제
MY177032A (en) * 2014-09-25 2020-09-02 Kowa Co Aqueous composition
AR105215A1 (es) * 2015-07-01 2017-09-13 Santen Pharmaceutical Co Ltd Formulación de depósito que contiene ésteres de ácido cítrico
EP3320904B1 (fr) * 2015-07-09 2023-07-05 Santen Pharmaceutical Co., Ltd. Agent préventif et/ou thérapeutique contenant un composé d'acide aminoacétique pyridyle pour traiter une maladie impliquant une pression intraoculaire très élevée
RU2745317C2 (ru) * 2016-02-22 2021-03-23 Сантен Фармасьютикал Ко., Лтд. Фармацевтическая композиция, включающая дорзоламид и бримонидин
AU2018283250B2 (en) 2017-06-16 2022-09-01 The Doshisha mTOR-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof
US20200121652A1 (en) 2017-06-16 2020-04-23 The Doshisha Compounds having caspase inhibitory activity, pharmaceutical agent containing said compounds and for treating or preventing corneal endothelial symptoms, disorders, or diseases, and application of said pharmaceutical agent
KR20200103041A (ko) * 2017-12-21 2020-09-01 산텐 세이야꾸 가부시키가이샤 오미데네팍의 조합
WO2019124489A1 (fr) * 2017-12-21 2019-06-27 参天製薬株式会社 Médicament comprenant une combinaison de sépétaprost et d'agoniste d'ep2
KR20200103719A (ko) * 2017-12-28 2020-09-02 산텐 세이야꾸 가부시키가이샤 피리딜아미노아세트산 화합물을 함유하는 의약 제제
JP2020033290A (ja) * 2018-08-29 2020-03-05 興和株式会社 水性組成物
US11608319B2 (en) 2019-12-31 2023-03-21 Industrial Technology Research Institute Beta-amino acid derivative, kinase inhibitor and pharmaceutical composition containing the same, and method for performing an in vivo related application that benefits from the inhibition of a kinase

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TW210287B (fr) * 1991-03-01 1993-08-01 Kabushikaisha Ueno Seiyaku Oyo Kenkyujo
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KR102074020B1 (ko) * 2012-07-13 2020-02-05 산텐 세이야꾸 가부시키가이샤 술폰아미드 화합물의 조합

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Publication number Priority date Publication date Assignee Title
US10149908B2 (en) 2014-01-10 2018-12-11 Santen Pharmaceutical Co., Ltd. Pharmaceutical composition containing pyridylaminoacetic acid compound
US10485872B2 (en) 2014-01-10 2019-11-26 Santen Pharmaceutical Co., Ltd. Pharmaceutical composition containing pyridylaminoacetic acid compound
US10765750B2 (en) 2014-01-10 2020-09-08 Santen Pharmaceutical Co., Ltd. Pharmaceutical composition containing pyridylaminoacetic acid compound

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JP2017186375A (ja) 2017-10-12
KR102074020B1 (ko) 2020-02-05
WO2014010654A2 (fr) 2014-01-16
JP6193655B2 (ja) 2017-09-06
PH12015500025A1 (en) 2015-02-23
CA3099517C (fr) 2022-04-26
JP6383058B2 (ja) 2018-08-29
CA3099517A1 (fr) 2014-01-16
JP6667583B2 (ja) 2020-03-18
WO2014010654A3 (fr) 2014-03-06
KR20150036320A (ko) 2015-04-07
TWI643619B (zh) 2018-12-11
TW201408297A (zh) 2014-03-01
JP2014031369A (ja) 2014-02-20
CA2878370C (fr) 2021-01-19
JP2018165285A (ja) 2018-10-25
PH12015500025B1 (en) 2015-02-23

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