CA2874461C - Formulations containing reversible covalent compounds - Google Patents
Formulations containing reversible covalent compounds Download PDFInfo
- Publication number
- CA2874461C CA2874461C CA2874461A CA2874461A CA2874461C CA 2874461 C CA2874461 C CA 2874461C CA 2874461 A CA2874461 A CA 2874461A CA 2874461 A CA2874461 A CA 2874461A CA 2874461 C CA2874461 C CA 2874461C
- Authority
- CA
- Canada
- Prior art keywords
- amino
- pyrimidin
- carbony1
- pyrazolo
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 323
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 245
- -1 chloro, fluoro, cyclopropyl Chemical group 0.000 claims description 201
- 239000001257 hydrogen Substances 0.000 claims description 185
- 229910052739 hydrogen Inorganic materials 0.000 claims description 185
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 172
- 150000003839 salts Chemical class 0.000 claims description 139
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 129
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 119
- 101100063435 Caenorhabditis elegans din-1 gene Proteins 0.000 claims description 104
- 238000009505 enteric coating Methods 0.000 claims description 98
- 239000002702 enteric coating Substances 0.000 claims description 98
- 125000005843 halogen group Chemical group 0.000 claims description 80
- 125000001424 substituent group Chemical group 0.000 claims description 80
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 79
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- 125000001153 fluoro group Chemical group F* 0.000 claims description 55
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- MAUMSNABMVEOGP-UHFFFAOYSA-N (methyl-$l^{2}-azanyl)methane Chemical compound C[N]C MAUMSNABMVEOGP-UHFFFAOYSA-N 0.000 claims description 3
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- FZERGXZRBYBPDM-UHFFFAOYSA-N 2-cyano-3-cyclopropylprop-2-enoic acid Chemical compound OC(=O)C(C#N)=CC1CC1 FZERGXZRBYBPDM-UHFFFAOYSA-N 0.000 claims description 2
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- DJGNVYRAZQWCKK-UHFFFAOYSA-N cyano 3-cyclopropylprop-2-enoate Chemical compound N#COC(=O)C=CC1CC1 DJGNVYRAZQWCKK-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261661203P | 2012-06-18 | 2012-06-18 | |
| US61/661,203 | 2012-06-18 | ||
| PCT/US2013/045266 WO2013191965A1 (en) | 2012-06-18 | 2013-06-11 | Reversible covalent pyrrolo- or pyrazolopyrimidines useful for the treatment cancer and autoimmune diseases |
Publications (2)
| Publication Number | Publication Date |
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| CA2874461A1 CA2874461A1 (en) | 2013-12-27 |
| CA2874461C true CA2874461C (en) | 2021-10-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2874461A Active CA2874461C (en) | 2012-06-18 | 2013-06-11 | Formulations containing reversible covalent compounds |
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|---|---|
| US (1) | US20160045503A1 (OSRAM) |
| EP (1) | EP2861599B1 (OSRAM) |
| JP (1) | JP6189945B2 (OSRAM) |
| KR (1) | KR102150432B1 (OSRAM) |
| CN (1) | CN104487441B (OSRAM) |
| AU (1) | AU2013277582B2 (OSRAM) |
| CA (1) | CA2874461C (OSRAM) |
| DK (1) | DK2861599T3 (OSRAM) |
| ES (1) | ES2776175T3 (OSRAM) |
| MX (1) | MX368112B (OSRAM) |
| WO (1) | WO2013191965A1 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9376438B2 (en) | 2011-05-17 | 2016-06-28 | Principia Biopharma, Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
| SI2710005T1 (sl) | 2011-05-17 | 2017-03-31 | Principia Biopharma Inc. | Zaviralci tirozinske kinaze |
| EA201490265A1 (ru) | 2011-07-13 | 2014-12-30 | Фармасайкликс, Инк. | Ингибиторы тирозинкиназы брутона |
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| US2809918A (en) | 1955-10-17 | 1957-10-15 | Victor M Hermelin | Sustained release pharmaceutical preparations |
| DE2010416B2 (de) | 1970-03-05 | 1979-03-29 | Hoechst Ag, 6000 Frankfurt | Oral anwendbare Arzneiform mit Retardwirkung |
| US4728512A (en) | 1985-05-06 | 1988-03-01 | American Home Products Corporation | Formulations providing three distinct releases |
| US4794001A (en) | 1986-03-04 | 1988-12-27 | American Home Products Corporation | Formulations providing three distinct releases |
| US20060045822A1 (en) | 2004-09-01 | 2006-03-02 | Board Of Regents, The University Of Texas System | Plasma polymerization for encapsulating particles |
| DK2529622T3 (en) * | 2006-09-22 | 2018-05-07 | Pharmacyclics Llc | INHIBITORS OF BRUTON-TYROSINKINASE |
| MX2012005678A (es) | 2009-11-16 | 2012-09-07 | Univ California | Enhibidores de cinasas. |
| SI2710005T1 (sl) * | 2011-05-17 | 2017-03-31 | Principia Biopharma Inc. | Zaviralci tirozinske kinaze |
| BR112013029508B1 (pt) * | 2011-05-17 | 2022-05-03 | Principia Biopharma, Inc. | Composto, composição farmacêutica, e, uso do referido composto |
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| AU2013277582B2 (en) | 2017-11-30 |
| CN104487441A (zh) | 2015-04-01 |
| WO2013191965A1 (en) | 2013-12-27 |
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| KR102150432B1 (ko) | 2020-09-01 |
| DK2861599T3 (da) | 2020-03-02 |
| HK1209103A1 (en) | 2016-03-24 |
| MX368112B (es) | 2019-09-18 |
| CA2874461A1 (en) | 2013-12-27 |
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| EP2861599A1 (en) | 2015-04-22 |
| KR20150023752A (ko) | 2015-03-05 |
| US20160045503A1 (en) | 2016-02-18 |
| CN104487441B (zh) | 2018-06-01 |
| JP6189945B2 (ja) | 2017-08-30 |
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