CA2867766C - Improved spacer membrane for an enzymatic in-vivo sensor - Google Patents

Improved spacer membrane for an enzymatic in-vivo sensor Download PDF

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Publication number
CA2867766C
CA2867766C CA2867766A CA2867766A CA2867766C CA 2867766 C CA2867766 C CA 2867766C CA 2867766 A CA2867766 A CA 2867766A CA 2867766 A CA2867766 A CA 2867766A CA 2867766 C CA2867766 C CA 2867766C
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CA
Canada
Prior art keywords
electrode system
hydrophilic
copolymer
methacrylate
acrylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2867766A
Other languages
English (en)
French (fr)
Other versions
CA2867766A1 (en
Inventor
Arnulf Staib
Marcel Thiele
Karl-Heinz Koelker
Ewald Rieger
Alexander Licht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/055406 external-priority patent/WO2012130841A1/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2867766A1 publication Critical patent/CA2867766A1/en
Application granted granted Critical
Publication of CA2867766C publication Critical patent/CA2867766C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
CA2867766A 2012-03-27 2013-03-27 Improved spacer membrane for an enzymatic in-vivo sensor Active CA2867766C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2012/055406 WO2012130841A1 (en) 2011-03-28 2012-03-27 Improved diffusion layer for an enzymatic in-vivo sensor
EPPCT/EP2012/055406 2012-03-27
PCT/EP2013/056619 WO2013144255A1 (en) 2012-03-27 2013-03-27 Improved spacer membrane for an enzymatic in-vivo sensor

Publications (2)

Publication Number Publication Date
CA2867766A1 CA2867766A1 (en) 2013-10-03
CA2867766C true CA2867766C (en) 2018-08-07

Family

ID=48014011

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2867766A Active CA2867766C (en) 2012-03-27 2013-03-27 Improved spacer membrane for an enzymatic in-vivo sensor

Country Status (5)

Country Link
JP (1) JP6374860B2 (ja)
CN (2) CN104334740B (ja)
CA (1) CA2867766C (ja)
RU (1) RU2611038C2 (ja)
WO (1) WO2013144255A1 (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3156790A1 (en) 2015-10-15 2017-04-19 ARKRAY, Inc. Biosensor and manufacturing method of biosensor
EP3156789B1 (en) 2015-10-15 2024-01-03 ARKRAY, Inc. Biosensor
HUE056062T2 (hu) 2016-02-05 2022-01-28 Hoffmann La Roche Orvostechnikai eszköz legalább egy analit kimutatására testfolyadékban
EP4241683B1 (en) 2016-02-05 2024-10-02 Roche Diabetes Care GmbH Medical device for detecting at least one analyte in a body fluid
EP3551760A1 (en) * 2016-12-08 2019-10-16 Roche Diabetes Care GmbH Sensor device for determining the concentration of an analyte underin-vivo
GB2559627A (en) * 2017-02-14 2018-08-15 Ndm Tech Ltd Device
EP3457121A1 (en) * 2017-09-18 2019-03-20 Roche Diabetes Care GmbH Electrochemical sensor and sensor system for detecting at least one analyte
DE202018006849U1 (de) 2017-12-21 2023-10-10 Roche Diabetes Care Gmbh Medizinisches System
CN111655147A (zh) 2018-01-29 2020-09-11 普和希控股公司 生物传感器探针用保护膜材料
US20210000393A1 (en) 2018-03-13 2021-01-07 Phc Holdings Corporation Protective film material for biosensor probe
EP3787509B1 (en) 2018-05-04 2022-06-22 F. Hoffmann-La Roche AG Improved diffusion layer for an enzymatic in-vivo sensor
CN108931568B (zh) * 2018-05-25 2020-09-01 南京佳乐净膜科技有限公司 生物传感器及其制备方法
US12016821B2 (en) 2018-08-23 2024-06-25 Abbott Diabetes Care Inc. Needle assemblies containing oriented acupuncture needles and methods for production thereof
KR102255448B1 (ko) * 2018-09-27 2021-05-24 주식회사 아이센스 혈중 글루코오스의 유입을 조절하는 중합체 블렌드, 이를 포함하는 연속 혈당 측정용 바이오센서
JP2021534371A (ja) * 2019-04-30 2021-12-09 微泰医療器械(杭州)股▲フン▼有限公司Microtech Medical (Hangzhou) Co., Ltd. 共重合体でコーティングされたバイオセンサーおよびその使用
JP2021525356A (ja) * 2019-04-30 2021-09-24 微泰医療器械（杭州）有限公司Ｍｉｃｒｏ Ｔｅｃｈ Ｍｅｄｉｃａｌ （Ｈａｎｇｚｈｏｕ） Ｃｏ．，Ｌｔｄ． 共重合体でコーティングされたバイオセンサーを有するバイオセンサシステムおよびその使用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6793789B2 (en) * 2000-09-30 2004-09-21 Geun Sig Cha Reference electrode with a polymeric reference electrode membrane
US7226978B2 (en) * 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
PT1603603E (pt) * 2003-02-28 2015-02-24 Biointeractions Ltd Sistema de rede polimérica para dispositivos médicos e métodos de utilização
US7109271B2 (en) * 2004-07-28 2006-09-19 Lifescan, Inc. Redox polymers for use in electrochemical-based sensors
US20060121547A1 (en) 2004-12-03 2006-06-08 Mcintire Mark Diffusion layer for an enzyme-based sensor application
US20060275859A1 (en) * 2005-05-17 2006-12-07 Kjaer Thomas Enzyme sensor including a water-containing spacer layer
DK1885871T3 (da) * 2005-05-17 2012-07-02 Radiometer Medical Aps Enzymsensor med et dækmembranlag af et porøst polymermaterial dækket af en hydrofil polymer
CA2654220A1 (en) 2006-06-19 2007-12-27 F. Hoffmann-La Roche Ag Amperometric sensor and method for its manufacturing
EP2124723A1 (en) * 2007-03-07 2009-12-02 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
EP2163190A1 (de) * 2008-09-11 2010-03-17 Roche Diagnostics GmbH Elektrodensystem für Messung einer Analytkonzentration in-vivo
EP2600761A4 (en) * 2010-08-06 2014-08-13 Microchips Inc MEMBRANE COMPOSITION FOR BIOSENSOR, BIOSENSOR AND METHODS OF MAKING THE SAME

Also Published As

Publication number Publication date
RU2014142913A (ru) 2016-05-20
CN106957887A (zh) 2017-07-18
CA2867766A1 (en) 2013-10-03
JP6374860B2 (ja) 2018-08-15
RU2611038C2 (ru) 2017-02-20
CN104334740B (zh) 2017-05-24
CN104334740A (zh) 2015-02-04
JP2015515305A (ja) 2015-05-28
WO2013144255A1 (en) 2013-10-03

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Effective date: 20140918

EEER Examination request

Effective date: 20140918