CA2865492C - Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios - Google Patents

Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios Download PDF

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Publication number
CA2865492C
CA2865492C CA2865492A CA2865492A CA2865492C CA 2865492 C CA2865492 C CA 2865492C CA 2865492 A CA2865492 A CA 2865492A CA 2865492 A CA2865492 A CA 2865492A CA 2865492 C CA2865492 C CA 2865492C
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Canada
Prior art keywords
isotope
individual
oscillations
systematic
detection
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CA2865492A
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English (en)
French (fr)
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CA2865492A1 (en
Inventor
Hamid R. Eghbalnia
Mark E. Cook
Warren Paul Porter
Daniel Elmer BUTZ
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Wisconsin Alumni Research Foundation
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Wisconsin Alumni Research Foundation
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4845—Toxicology, e.g. by detection of alcohol, drug or toxic products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
    • A61B5/0836—Measuring rate of CO2 production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physiology (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2865492A 2012-03-07 2013-01-07 Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios Active CA2865492C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/414,061 2012-03-07
US13/414,061 US8512676B1 (en) 2012-03-07 2012-03-07 Detection of rate changes in systematic oscillations of metabolic athways by monitoring isotope ratios
PCT/US2013/020496 WO2013133904A2 (en) 2012-03-07 2013-01-07 Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios

Publications (2)

Publication Number Publication Date
CA2865492A1 CA2865492A1 (en) 2013-09-12
CA2865492C true CA2865492C (en) 2021-06-01

Family

ID=47628440

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2865492A Active CA2865492C (en) 2012-03-07 2013-01-07 Detection of rate changes in systematic oscillations of metabolic pathways by monitoring isotope ratios

Country Status (8)

Country Link
US (1) US8512676B1 (cg-RX-API-DMAC7.html)
EP (1) EP2839277A2 (cg-RX-API-DMAC7.html)
JP (1) JP6396218B2 (cg-RX-API-DMAC7.html)
CN (1) CN104272107B (cg-RX-API-DMAC7.html)
AU (1) AU2013230841B2 (cg-RX-API-DMAC7.html)
CA (1) CA2865492C (cg-RX-API-DMAC7.html)
IN (1) IN2014DN07247A (cg-RX-API-DMAC7.html)
WO (1) WO2013133904A2 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104458603A (zh) * 2013-09-23 2015-03-25 苏州青山生物科技有限公司 一种新型幽门螺杆菌检测方法、装置及其应用
US20150196248A1 (en) 2014-01-10 2015-07-16 The United States Of America, As Represented By The Secretary Of Agriculture Methods of determining energy balance using breath carbon isotope ratios
US10226484B2 (en) 2014-12-01 2019-03-12 Peter Y Novak Pharmaceutical composition for improving health, cure abnormalities and degenerative disease, achieve anti-aging effect of therapy and therapeutic effect on mammals and method thereof
US10165965B1 (en) 2015-10-22 2019-01-01 Roy Pinchot Noninvasive method for measuring lactic acid and detection of anaerobic exercise for evaluating fitness
CN105954504B (zh) * 2016-06-01 2018-10-26 苏州科技学院 快速酒精定性信号处理方法以及初测装置
US10183041B2 (en) 2017-04-12 2019-01-22 Vector Vitale Ip Llc Antibacterial composition and its use in treating bacterial infections
US11484610B2 (en) 2019-11-22 2022-11-01 Vector Vitale Ip Llc Method of treating melanoma
US10799530B1 (en) 2019-12-20 2020-10-13 Vector Vitale Ip Llc Composition and method for the prevention and treatment of obesity
US10933091B1 (en) 2019-12-20 2021-03-02 Vector Vitale Ip Llc Composition and method for the treatment of type I diabetes
US11596650B2 (en) 2019-12-20 2023-03-07 Vector Vitale Ip Llc Composition and method for the treatment of type 2 diabetes
JP7718650B2 (ja) * 2021-05-19 2025-08-05 国立大学法人東北大学 感染症のバイオマーカ

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912178A (en) * 1994-02-16 1999-06-15 Wisconsin Alumni Research Foundation Passive measurement of isotopes to monitor health
JPH1087512A (ja) * 1996-09-18 1998-04-07 Isao Nishi ▲１３▼ｃ標識尿素試薬によるリアルタイムヘリコバクターピロリ感染検査方法
US6609068B2 (en) * 2000-02-22 2003-08-19 Dow Global Technologies Inc. Personal computer breath analyzer for health-related behavior modification and method
GB0120027D0 (en) * 2001-08-16 2001-10-10 Isis Innovation Spectroscopic breath analysis
US8512258B2 (en) * 2005-11-11 2013-08-20 Exalenz Bioscience Ltd. Breath test device and method
WO2007054940A2 (en) * 2005-11-11 2007-05-18 Breathid (2006) Breath test device and method
US7465276B2 (en) * 2005-11-30 2008-12-16 Wisconsin Alumni Research Foundation Identification of disease characteristics using isotope ratios in breath
WO2008074142A1 (en) * 2006-12-18 2008-06-26 Picomole Instruments Inc. Apparatus and method for rapid and accurate quantification of an unknown, complex mixture
US8026049B2 (en) * 2007-03-23 2011-09-27 Wisconsin Alumni Research Foundation Noninvasive measurement and identification of biomarkers in disease state
CN102027344B (zh) * 2008-02-15 2015-03-18 科学技术设备委员会 红外分光计
DE102009055321B4 (de) * 2009-12-24 2013-04-18 Humedics Gmbh Verfahren zur Bestimmung der Leberleistung eines Lebewesens mittels quantitativer Messung der Metabolisierung von Substraten

Also Published As

Publication number Publication date
EP2839277A2 (en) 2015-02-25
CA2865492A1 (en) 2013-09-12
IN2014DN07247A (cg-RX-API-DMAC7.html) 2015-04-24
US20130236925A1 (en) 2013-09-12
CN104272107A (zh) 2015-01-07
JP6396218B2 (ja) 2018-09-26
JP2015511009A (ja) 2015-04-13
AU2013230841A1 (en) 2014-09-11
CN104272107B (zh) 2017-05-17
AU2013230841B2 (en) 2018-09-27
US8512676B1 (en) 2013-08-20
WO2013133904A2 (en) 2013-09-12

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