CA2865395A1 - Variants of the lantibiotic mu1140 and other lantibiotics with improved pharmacological properties and structural features - Google Patents
Variants of the lantibiotic mu1140 and other lantibiotics with improved pharmacological properties and structural features Download PDFInfo
- Publication number
- CA2865395A1 CA2865395A1 CA2865395A CA2865395A CA2865395A1 CA 2865395 A1 CA2865395 A1 CA 2865395A1 CA 2865395 A CA2865395 A CA 2865395A CA 2865395 A CA2865395 A CA 2865395A CA 2865395 A1 CA2865395 A1 CA 2865395A1
- Authority
- CA
- Canada
- Prior art keywords
- changed
- ala
- ile
- bacteria
- combinations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G4/123—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261603693P | 2012-02-27 | 2012-02-27 | |
| US201261603661P | 2012-02-27 | 2012-02-27 | |
| US61/603,661 | 2012-02-27 | ||
| US61/603,693 | 2012-02-27 | ||
| PCT/US2013/027336 WO2013130349A1 (en) | 2012-02-27 | 2013-02-22 | Variants of the lantibiotic mu1140 and other lantibiotics with improved pharmacological properties and structural features |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2865395A1 true CA2865395A1 (en) | 2013-09-06 |
Family
ID=49083172
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2865395A Abandoned CA2865395A1 (en) | 2012-02-27 | 2013-02-22 | Variants of the lantibiotic mu1140 and other lantibiotics with improved pharmacological properties and structural features |
| CA2865405A Active CA2865405C (en) | 2012-02-27 | 2013-02-22 | Replacement therapy for dental caries |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2865405A Active CA2865405C (en) | 2012-02-27 | 2013-02-22 | Replacement therapy for dental caries |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9260488B2 (enExample) |
| EP (3) | EP2820036B1 (enExample) |
| JP (2) | JP6309902B2 (enExample) |
| CN (2) | CN104302307B (enExample) |
| AU (2) | AU2013226404B2 (enExample) |
| BR (2) | BR112014020656A2 (enExample) |
| CA (2) | CA2865395A1 (enExample) |
| HK (2) | HK1205458A1 (enExample) |
| MX (2) | MX369443B (enExample) |
| WO (2) | WO2013130351A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190315814A1 (en) * | 2016-07-15 | 2019-10-17 | Intrexon Corporation | Lantibiotic variants and uses thereof |
| US10577399B2 (en) | 2016-10-28 | 2020-03-03 | The Texas A&M University System | Modified lantibiotics and methods of making and using the modified lantibiotics |
| JP7605633B2 (ja) * | 2018-10-31 | 2024-12-24 | 株式会社村田製作所 | 抗グラム陰性菌化合物 |
| US20220133846A1 (en) * | 2019-03-08 | 2022-05-05 | Fraunhofer Usa Inc. | Novel antimicrobial compound and uses thereof |
| CN118490568B (zh) * | 2024-07-16 | 2024-10-18 | 南昌怀特科技有限公司 | 一种用于牙齿美白的抑菌凝胶及其制备方法与应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4366246A (en) | 1977-11-08 | 1982-12-28 | Genentech, Inc. | Method for microbial polypeptide expression |
| US5516682A (en) * | 1988-07-05 | 1996-05-14 | University Of Maryland | Subtilin variant of enhanced stability and activity |
| GB9423404D0 (en) * | 1994-11-19 | 1995-01-11 | Biotech & Biolog Scien Res | Production of nisin |
| US6964760B2 (en) * | 1997-06-10 | 2005-11-15 | University Of Florida Research Foundation | Antimicrobial polypeptide, nucleic acid, and methods of use |
| US20060198793A1 (en) * | 1997-06-10 | 2006-09-07 | University Of Florida Research Foundation | Antimicrobial polypeptide, nucleic acid, and methods of use |
| US5932469A (en) * | 1997-06-10 | 1999-08-03 | University Of Florida | Antimicrobial polypeptide, nucleic acid, and methods of use |
| US6251478B1 (en) | 1999-12-22 | 2001-06-26 | Balchem Corporation | Sensitive substance encapsulation |
| CN1639318B (zh) * | 2002-02-22 | 2010-04-21 | 布利斯技术有限公司 | 抗微生物组合物 |
| US20090215985A1 (en) * | 2005-08-12 | 2009-08-27 | Oragenics, Inc. | Differentially protected orthogonal lanthionine technology |
| JP4955001B2 (ja) | 2005-08-12 | 2012-06-20 | オラジェニックス,インコーポレイテッド | 特異的に保護された直交ランチオニン技術 |
| WO2007044745A1 (en) * | 2005-10-11 | 2007-04-19 | Biosynexus Incorporated | Lantibiotic and mupirocin compositions for treating bacterial infections |
| CA2690267A1 (en) * | 2007-06-12 | 2008-12-18 | The University Of British Columbia | Small cationic antimicrobial peptides |
| DK2176284T3 (da) * | 2007-07-20 | 2013-10-14 | Univ Minnesota | Lantibiotika og anvendelser deraf |
| IE20080365A1 (en) * | 2008-05-09 | 2010-03-16 | Univ College Cork Nat Univ Ie | Nisin derivatives and the use thereof |
-
2013
- 2013-02-22 AU AU2013226404A patent/AU2013226404B2/en not_active Ceased
- 2013-02-22 JP JP2014558870A patent/JP6309902B2/ja active Active
- 2013-02-22 MX MX2014010151A patent/MX369443B/es active IP Right Grant
- 2013-02-22 JP JP2014558872A patent/JP6297506B2/ja not_active Expired - Fee Related
- 2013-02-22 BR BR112014020656A patent/BR112014020656A2/pt not_active Application Discontinuation
- 2013-02-22 AU AU2013226402A patent/AU2013226402B2/en not_active Ceased
- 2013-02-22 MX MX2014010143A patent/MX358060B/es active IP Right Grant
- 2013-02-22 CA CA2865395A patent/CA2865395A1/en not_active Abandoned
- 2013-02-22 EP EP13755436.6A patent/EP2820036B1/en active Active
- 2013-02-22 US US14/381,524 patent/US9260488B2/en active Active
- 2013-02-22 US US14/381,420 patent/US9963488B2/en active Active
- 2013-02-22 WO PCT/US2013/027340 patent/WO2013130351A1/en not_active Ceased
- 2013-02-22 WO PCT/US2013/027336 patent/WO2013130349A1/en not_active Ceased
- 2013-02-22 HK HK15106033.9A patent/HK1205458A1/xx unknown
- 2013-02-22 CN CN201380011187.9A patent/CN104302307B/zh not_active Expired - Fee Related
- 2013-02-22 BR BR112014020659A patent/BR112014020659A2/pt not_active IP Right Cessation
- 2013-02-22 EP EP13755353.3A patent/EP2833902A4/en not_active Withdrawn
- 2013-02-22 EP EP17000662.1A patent/EP3219325B1/en active Active
- 2013-02-22 CA CA2865405A patent/CA2865405C/en active Active
- 2013-02-22 HK HK15106032.0A patent/HK1205519A1/xx unknown
- 2013-02-22 CN CN201380011223.1A patent/CN104321338B/zh not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180129 |
|
| FZDE | Discontinued |
Effective date: 20210831 |
|
| FZDE | Discontinued |
Effective date: 20210831 |