CA2865058C - Multi-reflection mass spectrometer - Google Patents
Multi-reflection mass spectrometer Download PDFInfo
- Publication number
- CA2865058C CA2865058C CA2865058A CA2865058A CA2865058C CA 2865058 C CA2865058 C CA 2865058C CA 2865058 A CA2865058 A CA 2865058A CA 2865058 A CA2865058 A CA 2865058A CA 2865058 C CA2865058 C CA 2865058C
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- Prior art keywords
- mirrors
- ions
- ion
- drift
- mass spectrometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/06—Electron- or ion-optical arrangements
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
- H01J49/406—Time-of-flight spectrometers with multiple reflections
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/4245—Electrostatic ion traps
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1201405.6 | 2012-01-27 | ||
| GB201201405A GB201201405D0 (en) | 2012-01-27 | 2012-01-27 | Multi-reflection mass spectrometer |
| PCT/EP2013/051103 WO2013110588A2 (en) | 2012-01-27 | 2013-01-22 | Multi-reflection mass spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2865058A1 CA2865058A1 (en) | 2013-08-01 |
| CA2865058C true CA2865058C (en) | 2017-10-10 |
Family
ID=45876187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2865058A Active CA2865058C (en) | 2012-01-27 | 2013-01-22 | Multi-reflection mass spectrometer |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9136102B2 (enExample) |
| JP (1) | JP6236016B2 (enExample) |
| CN (1) | CN104067371B (enExample) |
| CA (1) | CA2865058C (enExample) |
| DE (1) | DE112013000722B4 (enExample) |
| GB (2) | GB201201405D0 (enExample) |
| IN (1) | IN2014DN06160A (enExample) |
| WO (1) | WO2013110588A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201201403D0 (en) | 2012-01-27 | 2012-03-14 | Thermo Fisher Scient Bremen | Multi-reflection mass spectrometer |
| GB2546355A (en) * | 2014-03-31 | 2017-07-19 | Leco Corp | GC-TOF MS With improved detection limit |
| GB201507363D0 (en) * | 2015-04-30 | 2015-06-17 | Micromass Uk Ltd And Leco Corp | Multi-reflecting TOF mass spectrometer |
| GB201520130D0 (en) | 2015-11-16 | 2015-12-30 | Micromass Uk Ltd And Leco Corp | Imaging mass spectrometer |
| GB201520134D0 (en) | 2015-11-16 | 2015-12-30 | Micromass Uk Ltd And Leco Corp | Imaging mass spectrometer |
| GB201520540D0 (en) | 2015-11-23 | 2016-01-06 | Micromass Uk Ltd And Leco Corp | Improved ion mirror and ion-optical lens for imaging |
| US10199208B2 (en) * | 2016-03-03 | 2019-02-05 | Thermo Finnigan Llc | Ion beam mass pre-separator |
| CN106057626B (zh) * | 2016-06-06 | 2017-12-29 | 复旦大学 | 三维离子淌度质谱联用仪 |
| GB201613988D0 (en) * | 2016-08-16 | 2016-09-28 | Micromass Uk Ltd And Leco Corp | Mass analyser having extended flight path |
| GB2555609B (en) * | 2016-11-04 | 2019-06-12 | Thermo Fisher Scient Bremen Gmbh | Multi-reflection mass spectrometer with deceleration stage |
| GB2567794B (en) | 2017-05-05 | 2023-03-08 | Micromass Ltd | Multi-reflecting time-of-flight mass spectrometers |
| GB2563571B (en) * | 2017-05-26 | 2023-05-24 | Micromass Ltd | Time of flight mass analyser with spatial focussing |
| GB2563604B (en) | 2017-06-20 | 2021-03-10 | Thermo Fisher Scient Bremen Gmbh | Mass spectrometer and method for time-of-flight mass spectrometry |
| US11211238B2 (en) | 2017-08-06 | 2021-12-28 | Micromass Uk Limited | Multi-pass mass spectrometer |
| US11817303B2 (en) | 2017-08-06 | 2023-11-14 | Micromass Uk Limited | Accelerator for multi-pass mass spectrometers |
| WO2019030474A1 (en) | 2017-08-06 | 2019-02-14 | Anatoly Verenchikov | IONIC MIRROR WITH PRINTED CIRCUIT WITH COMPENSATION |
| US11081332B2 (en) | 2017-08-06 | 2021-08-03 | Micromass Uk Limited | Ion guide within pulsed converters |
| EP3662501A1 (en) * | 2017-08-06 | 2020-06-10 | Micromass UK Limited | Ion mirror for multi-reflecting mass spectrometers |
| US11205568B2 (en) | 2017-08-06 | 2021-12-21 | Micromass Uk Limited | Ion injection into multi-pass mass spectrometers |
| WO2019030473A1 (en) * | 2017-08-06 | 2019-02-14 | Anatoly Verenchikov | FIELDS FOR SMART REFLECTIVE TOF SM |
| WO2019060538A1 (en) | 2017-09-20 | 2019-03-28 | The Trustees Of Indiana University | METHODS FOR LIPOPROTEIN RESOLUTION BY MASS SPECTROMETRY |
| CN109841488B (zh) * | 2017-11-27 | 2020-07-07 | 中国科学院大连化学物理研究所 | 一种用于离子存储的大容量静电离子阱 |
| EP3738137A1 (en) | 2018-01-12 | 2020-11-18 | The Trustees of Indiana University | Electrostatic linear ion trap design for charge detection mass spectrometry |
| GB201802917D0 (en) | 2018-02-22 | 2018-04-11 | Micromass Ltd | Charge detection mass spectrometry |
| GB201806507D0 (en) | 2018-04-20 | 2018-06-06 | Verenchikov Anatoly | Gridless ion mirrors with smooth fields |
| GB201807605D0 (en) | 2018-05-10 | 2018-06-27 | Micromass Ltd | Multi-reflecting time of flight mass analyser |
| GB201807626D0 (en) | 2018-05-10 | 2018-06-27 | Micromass Ltd | Multi-reflecting time of flight mass analyser |
| GB201808459D0 (en) * | 2018-05-23 | 2018-07-11 | Thermo Fisher Scient Bremen Gmbh | Ion front tilt correction for time of flight(tof) mass spectrometer |
| GB201808530D0 (en) | 2018-05-24 | 2018-07-11 | Verenchikov Anatoly | TOF MS detection system with improved dynamic range |
| EP4376051A3 (en) | 2018-06-04 | 2024-09-25 | The Trustees of Indiana University | Charge detection mass spectrometry with real time analysis and signal optimization |
| AU2019281715B2 (en) | 2018-06-04 | 2024-06-13 | The Trustees Of Indiana University | Apparatus and method for capturing ions in an electrostatic linear ion trap |
| JP7398811B2 (ja) | 2018-06-04 | 2023-12-15 | ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー | 高スループット電荷検出質量分光分析のためのイオン・トラップ・アレイ |
| WO2019236143A1 (en) | 2018-06-04 | 2019-12-12 | The Trustees Of Indiana University | Apparatus and method for calibrating or resetting a charge detector |
| WO2019236139A1 (en) | 2018-06-04 | 2019-12-12 | The Trustees Of Indiana University | Interface for transporting ions from an atmospheric pressure environment to a low pressure environment |
| GB201810573D0 (en) | 2018-06-28 | 2018-08-15 | Verenchikov Anatoly | Multi-pass mass spectrometer with improved duty cycle |
| WO2020106310A1 (en) | 2018-11-20 | 2020-05-28 | The Trustees Of Indiana University | Orbitrap for single particle mass spectrometry |
| KR102742959B1 (ko) | 2018-12-03 | 2024-12-16 | 더 트러스티즈 오브 인디애나 유니버시티 | 정전 선형 이온 트랩을 이용하여 다수의 이온을 동시에 분석하기 위한 장치 및 방법 |
| GB2580089B (en) * | 2018-12-21 | 2021-03-03 | Thermo Fisher Scient Bremen Gmbh | Multi-reflection mass spectrometer |
| GB201901411D0 (en) | 2019-02-01 | 2019-03-20 | Micromass Ltd | Electrode assembly for mass spectrometer |
| GB201903779D0 (en) | 2019-03-20 | 2019-05-01 | Micromass Ltd | Multiplexed time of flight mass spectrometer |
| US11942317B2 (en) | 2019-04-23 | 2024-03-26 | The Trustees Of Indiana University | Identification of sample subspecies based on particle mass and charge over a range of sample temperatures |
| JP7671510B2 (ja) | 2019-09-25 | 2025-05-02 | ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー | パルス・モード電荷検出質量分析のための装置および方法 |
| WO2021072186A1 (en) | 2019-10-10 | 2021-04-15 | The Trustees Of Indiana University | System and method for identifying, selecting and purifying particles |
| KR20220117264A (ko) | 2019-12-18 | 2022-08-23 | 더 트러스티즈 오브 인디애나 유니버시티 | 전하 측정 배열체를 구비한 질량 분석기 |
| WO2021142651A1 (en) * | 2020-01-15 | 2021-07-22 | Shanghai Polaris Biology Co., Ltd. | Particle mass spectrometry |
| CA3166860A1 (en) | 2020-02-03 | 2021-08-12 | The Trustees Of Indiana University | Time-domain analysis of signals for charge detection mass spectrometry |
| GB2592591B (en) | 2020-03-02 | 2024-07-24 | Thermo Fisher Scient Bremen Gmbh | Time of flight mass spectrometer and method of mass spectrometry |
| WO2021207494A1 (en) | 2020-04-09 | 2021-10-14 | Waters Technologies Corporation | Ion detector |
| CN112687517B (zh) * | 2020-12-28 | 2024-03-15 | 中国人民公安大学 | 基于反射和检测的离子迁移谱结构 |
| GB2620476B (en) * | 2021-06-02 | 2024-08-28 | Thermo Fisher Scient Bremen Gmbh | Mass analyser |
| GB2607580B (en) | 2021-06-02 | 2023-08-09 | Thermo Fisher Scient Bremen Gmbh | Voltage supply for a mass analyser |
| WO2023111707A1 (en) | 2021-12-15 | 2023-06-22 | Waters Technologies Corporation | An inductive detector with integrated amplifier |
| GB2619766B (en) * | 2022-06-17 | 2024-12-18 | Thermo Fisher Scient Bremen Gmbh | Time-of-flight mass spectrometric analysis of labelled analyte molecules |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3025764C2 (de) | 1980-07-08 | 1984-04-19 | Hermann Prof. Dr. 6301 Fernwald Wollnik | Laufzeit-Massenspektrometer |
| JPH03503815A (ja) | 1987-12-24 | 1991-08-22 | ユニサーチ リミテッド | 質量分析計 |
| SU1725289A1 (ru) | 1989-07-20 | 1992-04-07 | Институт Ядерной Физики Ан Казсср | Врем пролетный масс-спектрометр с многократным отражением |
| US7385187B2 (en) | 2003-06-21 | 2008-06-10 | Leco Corporation | Multi-reflecting time-of-flight mass spectrometer and method of use |
| GB2403063A (en) * | 2003-06-21 | 2004-12-22 | Anatoli Nicolai Verentchikov | Time of flight mass spectrometer employing a plurality of lenses focussing an ion beam in shift direction |
| US6998607B1 (en) | 2004-08-31 | 2006-02-14 | Thermo Finnigan Llc | Temperature compensated time-of-flight mass spectrometer |
| WO2006102430A2 (en) | 2005-03-22 | 2006-09-28 | Leco Corporation | Multi-reflecting time-of-flight mass spectrometer with isochronous curved ion interface |
| CA2624926C (en) | 2005-10-11 | 2017-05-09 | Leco Corporation | Multi-reflecting time-of-flight mass spectrometer with orthogonal acceleration |
| US7829850B2 (en) | 2006-03-09 | 2010-11-09 | Thermo Finnigan Llc | Branched radio frequency multipole |
| GB0607542D0 (en) | 2006-04-13 | 2006-05-24 | Thermo Finnigan Llc | Mass spectrometer |
| GB2447195B (en) | 2006-04-13 | 2011-08-17 | Thermo Fisher Scient | Ion energy spread reduction for mass spectrometer |
| GB0620398D0 (en) | 2006-10-13 | 2006-11-22 | Shimadzu Corp | Multi-reflecting time-of-flight mass analyser and a time-of-flight mass spectrometer including the time-of-flight mass analyser |
| US7605377B2 (en) * | 2006-10-17 | 2009-10-20 | Zyvex Corporation | On-chip reflectron and ion optics |
| GB0626025D0 (en) | 2006-12-29 | 2007-02-07 | Thermo Electron Bremen Gmbh | Ion trap |
| GB0712252D0 (en) | 2007-06-22 | 2007-08-01 | Shimadzu Corp | A multi-reflecting ion optical device |
| GB2455977A (en) | 2007-12-21 | 2009-07-01 | Thermo Fisher Scient | Multi-reflectron time-of-flight mass spectrometer |
| JP5628165B2 (ja) * | 2008-07-16 | 2014-11-19 | レコ コーポレイションＬｅｃｏ Ｃｏｒｐｏｒａｔｉｏｎ | 疑似平面多重反射飛行時間型質量分析計 |
| US7952070B2 (en) | 2009-01-12 | 2011-05-31 | Thermo Finnigan Llc | Interlaced Y multipole |
| GB2470599B (en) | 2009-05-29 | 2014-04-02 | Thermo Fisher Scient Bremen | Charged particle analysers and methods of separating charged particles |
| US20110168880A1 (en) * | 2010-01-13 | 2011-07-14 | Agilent Technologies, Inc. | Time-of-flight mass spectrometer with curved ion mirrors |
| GB2476964A (en) | 2010-01-15 | 2011-07-20 | Anatoly Verenchikov | Electrostatic trap mass spectrometer |
| DE102010034078B4 (de) | 2010-08-12 | 2012-06-06 | Bruker Daltonik Gmbh | Kingdon-Massenspektrometer mit zylindrischen Elektroden |
| GB2496991B (en) | 2010-11-26 | 2015-05-20 | Thermo Fisher Scient Bremen | Method of mass selecting ions and mass selector |
| GB201201403D0 (en) * | 2012-01-27 | 2012-03-14 | Thermo Fisher Scient Bremen | Multi-reflection mass spectrometer |
-
2012
- 2012-01-27 GB GB201201405A patent/GB201201405D0/en not_active Ceased
-
2013
- 2013-01-22 CA CA2865058A patent/CA2865058C/en active Active
- 2013-01-22 US US14/374,221 patent/US9136102B2/en active Active
- 2013-01-22 IN IN6160DEN2014 patent/IN2014DN06160A/en unknown
- 2013-01-22 CN CN201380006060.8A patent/CN104067371B/zh active Active
- 2013-01-22 GB GB1412003.4A patent/GB2512773B/en active Active
- 2013-01-22 WO PCT/EP2013/051103 patent/WO2013110588A2/en not_active Ceased
- 2013-01-22 JP JP2014553680A patent/JP6236016B2/ja active Active
- 2013-01-22 DE DE112013000722.3T patent/DE112013000722B4/de active Active
-
2015
- 2015-09-14 US US14/853,892 patent/US9673033B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| GB201412003D0 (en) | 2014-08-20 |
| WO2013110588A2 (en) | 2013-08-01 |
| CN104067371B (zh) | 2017-04-12 |
| JP6236016B2 (ja) | 2017-11-22 |
| US9136102B2 (en) | 2015-09-15 |
| US20150028198A1 (en) | 2015-01-29 |
| CN104067371A (zh) | 2014-09-24 |
| US20160005580A1 (en) | 2016-01-07 |
| WO2013110588A3 (en) | 2014-01-30 |
| GB201201405D0 (en) | 2012-03-14 |
| IN2014DN06160A (enExample) | 2015-08-21 |
| CA2865058A1 (en) | 2013-08-01 |
| DE112013000722T5 (de) | 2014-11-06 |
| DE112013000722B4 (de) | 2022-10-13 |
| JP2015506567A (ja) | 2015-03-02 |
| US9673033B2 (en) | 2017-06-06 |
| GB2512773A (en) | 2014-10-08 |
| GB2512773B (en) | 2020-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140725 |