CA2864421C - Device for in-vivo determination of eye moisture - Google Patents
Device for in-vivo determination of eye moisture Download PDFInfo
- Publication number
- CA2864421C CA2864421C CA2864421A CA2864421A CA2864421C CA 2864421 C CA2864421 C CA 2864421C CA 2864421 A CA2864421 A CA 2864421A CA 2864421 A CA2864421 A CA 2864421A CA 2864421 C CA2864421 C CA 2864421C
- Authority
- CA
- Canada
- Prior art keywords
- electrode
- moisture
- electrode arrangement
- electrodes
- characterization parameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000001727 in vivo Methods 0.000 title claims abstract description 48
- 210000004872 soft tissue Anatomy 0.000 claims abstract description 46
- 238000000034 method Methods 0.000 claims abstract description 38
- 210000000744 eyelid Anatomy 0.000 claims abstract description 32
- 206010013774 Dry eye Diseases 0.000 claims description 27
- 238000012512 characterization method Methods 0.000 claims description 24
- 239000000758 substrate Substances 0.000 claims description 21
- 238000000338 in vitro Methods 0.000 claims description 17
- 230000002596 correlated effect Effects 0.000 claims description 16
- 238000012360 testing method Methods 0.000 claims description 16
- 230000003247 decreasing effect Effects 0.000 claims description 10
- 230000007246 mechanism Effects 0.000 claims description 10
- 210000001519 tissue Anatomy 0.000 claims description 9
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 239000000560 biocompatible material Substances 0.000 claims description 6
- 239000003990 capacitor Substances 0.000 claims description 6
- 238000010186 staining Methods 0.000 claims description 5
- 208000023715 Ocular surface disease Diseases 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 3
- 238000011156 evaluation Methods 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 16
- 239000007788 liquid Substances 0.000 description 12
- 230000006870 function Effects 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 210000004087 cornea Anatomy 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 229920000515 polycarbonate Polymers 0.000 description 4
- 239000004417 polycarbonate Substances 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 208000009319 Keratoconjunctivitis Sicca Diseases 0.000 description 3
- 108091006629 SLC13A2 Proteins 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000003792 electrolyte Substances 0.000 description 3
- 210000004907 gland Anatomy 0.000 description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 210000000795 conjunctiva Anatomy 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 210000003717 douglas' pouch Anatomy 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 230000005499 meniscus Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920000379 polypropylene carbonate Polymers 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 101000939456 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 29 Proteins 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 102100029818 Ubiquitin carboxyl-terminal hydrolase 29 Human genes 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008378 epithelial damage Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 238000012623 in vivo measurement Methods 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 210000004175 meibomian gland Anatomy 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000004489 tear production Effects 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/101—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the tear film
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Eye Examination Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1202387.5 | 2012-02-13 | ||
| GBGB1202387.5A GB201202387D0 (en) | 2012-02-13 | 2012-02-13 | Device for in-vivo determination of eye moisture |
| PCT/IB2013/000173 WO2013121263A1 (en) | 2012-02-13 | 2013-02-12 | Device for in-vivo determination of eye moisture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2864421A1 CA2864421A1 (en) | 2013-08-22 |
| CA2864421C true CA2864421C (en) | 2022-03-01 |
Family
ID=45929982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2864421A Active CA2864421C (en) | 2012-02-13 | 2013-02-12 | Device for in-vivo determination of eye moisture |
Country Status (13)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104757972B (zh) * | 2015-03-16 | 2024-02-06 | 思澜科技（成都）有限公司 | 一种用于生物阻抗测量的活检夹 |
| AU2016277825B2 (en) | 2015-06-16 | 2019-04-18 | The Regents Of The University Of Colorado, A Body Corporate | Nasolacrimal implants and related methods for tear stimulation |
| ITUB20154761A1 (it) * | 2015-10-29 | 2017-04-29 | Resono Ophthalmic S R L | Sistema di elettrodo e relativo dispositivo per il trattamento di patologie dell?occhio, in particolare dell?occhio secco |
| US10386655B2 (en) | 2016-07-27 | 2019-08-20 | Verily Life Sciences Llc | Device, system and method for detecting overlap of an ophthalmic device by an eyelid |
| KR102342997B1 (ko) * | 2020-05-15 | 2021-12-23 | 충북대학교 산학협력단 | 오스몰 농도 측정 장치 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4996993A (en) * | 1988-12-07 | 1991-03-05 | York Kenneth K | In vivo osmometer |
| US4951683A (en) * | 1989-01-19 | 1990-08-28 | Davis Jeffrey P | Device for detecting keratoconjunctivitis sicca |
| US5961471A (en) | 1995-02-28 | 1999-10-05 | Nova Technology Corporation | Probe for a biophysical skin measurement device |
| US6245064B1 (en) | 1997-07-08 | 2001-06-12 | Atrionix, Inc. | Circumferential ablation device assembly |
| GB2339912B (en) | 1998-07-20 | 2002-06-05 | Univ Bristol | Apparatus and method for measuring the moisture level within enamel dentine or tooth tissue |
| GB2359893B (en) * | 2000-02-29 | 2004-09-29 | Rynhart Res Ltd | A moisture meter with impedence and relative humidity measurements |
| WO2004017050A1 (en) * | 2002-08-06 | 2004-02-26 | The Regents Of The University Of California | Tear film osmometry |
| US7051569B2 (en) | 2002-08-06 | 2006-05-30 | Ocusense, Inc. | Systems and methods for calibrating osmolarity measuring devices |
| US7111502B2 (en) | 2002-08-06 | 2006-09-26 | Ocusense, Inc. | Systems and methods for reducing the effect of corruptive signals during nanoliter osmometry |
| US7905134B2 (en) | 2002-08-06 | 2011-03-15 | The Regents Of The University Of California | Biomarker normalization |
| US8020433B2 (en) | 2003-03-25 | 2011-09-20 | Tearlab Research, Inc. | Systems and methods for a sample fluid collection device |
| CA2539547A1 (en) * | 2003-08-20 | 2005-03-03 | Philometron, Inc. | Hydration monitoring |
| JP4593573B2 (ja) | 2004-01-08 | 2010-12-08 | オスモペン， リミテッド ライアビリティ カンパニー | 表面プラズモン共鳴型ナノリットル浸透圧計 |
| US7297123B2 (en) | 2004-04-19 | 2007-11-20 | Nova Technology Corporation | Method and apparatus for accessing oral mucositis |
| US7182509B2 (en) | 2005-04-27 | 2007-02-27 | Advanced Instruments, Inc. | Nanoliter osmometer and method of operation |
| US7344679B2 (en) * | 2005-10-14 | 2008-03-18 | International Business Machines Corporation | Method and apparatus for point of care osmolarity testing |
| US7908906B2 (en) | 2006-08-29 | 2011-03-22 | International Business Machines Corporation | Fluidic test apparatus and method |
| JP2008154857A (ja) * | 2006-12-25 | 2008-07-10 | Meiyoo:Kk | 角膜抵抗測定装置及びそれに用いられる角膜抵抗測定用電極装置 |
| US7762718B2 (en) | 2007-09-28 | 2010-07-27 | International Business Machines Corporation | Condensation detector utilizing a wet bulb and dry bulb temperature differential |
| US20100069779A1 (en) * | 2008-09-15 | 2010-03-18 | Zvi Nachum | Soft tissue moisture analyzer |
-
2012
- 2012-02-13 GB GBGB1202387.5A patent/GB201202387D0/en not_active Ceased
-
2013
- 2013-02-12 KR KR1020147025617A patent/KR102129145B1/ko active Active
- 2013-02-12 JP JP2014556148A patent/JP6086931B2/ja active Active
- 2013-02-12 PL PL13715738T patent/PL2814378T3/pl unknown
- 2013-02-12 CN CN201380019648.7A patent/CN104244805B/zh active Active
- 2013-02-12 CA CA2864421A patent/CA2864421C/en active Active
- 2013-02-12 AU AU2013220118A patent/AU2013220118B2/en active Active
- 2013-02-12 EP EP13715738.4A patent/EP2814378B1/en active Active
- 2013-02-12 ES ES13715738.4T patent/ES2664330T3/es active Active
- 2013-02-12 BR BR112014020109-9A patent/BR112014020109B1/pt active IP Right Grant
- 2013-02-12 WO PCT/IB2013/000173 patent/WO2013121263A1/en active Application Filing
-
2014
- 2014-08-12 IL IL234084A patent/IL234084B/en not_active IP Right Cessation
- 2014-08-13 US US14/458,344 patent/US9833138B2/en active Active
-
2017
- 2017-10-29 US US15/796,806 patent/US10716466B2/en active Active
-
2020
- 2020-02-27 US US16/803,389 patent/US20200260947A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013121263A1 (en) | 2013-08-22 |
| PL2814378T3 (pl) | 2018-07-31 |
| ES2664330T3 (es) | 2018-04-19 |
| JP6086931B2 (ja) | 2017-03-01 |
| US20180125353A1 (en) | 2018-05-10 |
| GB201202387D0 (en) | 2012-03-28 |
| BR112014020109A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2017-06-20 |
| EP2814378A1 (en) | 2014-12-24 |
| AU2013220118B2 (en) | 2017-10-12 |
| US9833138B2 (en) | 2017-12-05 |
| KR102129145B1 (ko) | 2020-07-02 |
| AU2013220118A1 (en) | 2014-09-25 |
| CA2864421A1 (en) | 2013-08-22 |
| IL234084A0 (en) | 2014-09-30 |
| US20200260947A1 (en) | 2020-08-20 |
| CN104244805B (zh) | 2017-10-31 |
| BR112014020109B1 (pt) | 2021-12-14 |
| US10716466B2 (en) | 2020-07-21 |
| US20140350376A1 (en) | 2014-11-27 |
| US20170347875A9 (en) | 2017-12-07 |
| IL234084B (en) | 2020-05-31 |
| CN104244805A (zh) | 2014-12-24 |
| EP2814378B1 (en) | 2018-01-03 |
| BR112014020109A8 (pt) | 2017-07-11 |
| KR20140130473A (ko) | 2014-11-10 |
| JP2015513348A (ja) | 2015-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180212 |