CA2863368A1 - Managing back pain by applying a high frequency electrical stimulus directly to the spinal cord - Google Patents

Managing back pain by applying a high frequency electrical stimulus directly to the spinal cord Download PDF

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Publication number
CA2863368A1
CA2863368A1 CA2863368A CA2863368A CA2863368A1 CA 2863368 A1 CA2863368 A1 CA 2863368A1 CA 2863368 A CA2863368 A CA 2863368A CA 2863368 A CA2863368 A CA 2863368A CA 2863368 A1 CA2863368 A1 CA 2863368A1
Authority
CA
Canada
Prior art keywords
spinal cord
back pain
high frequency
electrical stimulus
applying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2863368A
Other languages
English (en)
French (fr)
Inventor
Matthew Howard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Iowa Research Foundation UIRF
Original Assignee
University of Iowa Research Foundation UIRF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Iowa Research Foundation UIRF filed Critical University of Iowa Research Foundation UIRF
Publication of CA2863368A1 publication Critical patent/CA2863368A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36071—Pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0553—Paddle shaped electrodes, e.g. for laminotomy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0558—Anchoring or fixation means therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/06—Electrodes for high-frequency therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36103—Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A61N1/37223—Circuits for electromagnetic coupling

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Acoustics & Sound (AREA)
  • Electromagnetism (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rehabilitation Therapy (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
CA2863368A 2012-01-30 2013-01-30 Managing back pain by applying a high frequency electrical stimulus directly to the spinal cord Abandoned CA2863368A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261592520P 2012-01-30 2012-01-30
US61/592,520 2012-01-30
PCT/US2013/023897 WO2013116368A1 (en) 2012-01-30 2013-01-30 Managing back pain by applying a high frequency electrical stimulus directly to the spinal cord

Publications (1)

Publication Number Publication Date
CA2863368A1 true CA2863368A1 (en) 2013-08-08

Family

ID=48905795

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2863368A Abandoned CA2863368A1 (en) 2012-01-30 2013-01-30 Managing back pain by applying a high frequency electrical stimulus directly to the spinal cord

Country Status (6)

Country Link
US (2) US9403008B2 (enExample)
EP (1) EP2809389B1 (enExample)
JP (1) JP6196634B2 (enExample)
CN (1) CN104203338B (enExample)
CA (1) CA2863368A1 (enExample)
WO (1) WO2013116368A1 (enExample)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8361067B2 (en) 2002-09-30 2013-01-29 Relievant Medsystems, Inc. Methods of therapeutically heating a vertebral body to treat back pain
US6907884B2 (en) 2002-09-30 2005-06-21 Depay Acromed, Inc. Method of straddling an intraosseous nerve
US7258690B2 (en) 2003-03-28 2007-08-21 Relievant Medsystems, Inc. Windowed thermal ablation probe
US10028753B2 (en) 2008-09-26 2018-07-24 Relievant Medsystems, Inc. Spine treatment kits
JP5688022B2 (ja) 2008-09-26 2015-03-25 リリーバント メドシステムズ、インコーポレイテッド 骨の内部を通って器具を誘導するためのシステムおよび方法
US10071240B2 (en) 2010-11-11 2018-09-11 University Of Iowa Research Foundation Floating electrodes that engage and accommodate movement of the spinal cord
US9364660B2 (en) 2010-11-11 2016-06-14 University Of Iowa Research Foundation Electrode array device configured for placement inside the dura for direct spinal cord stimulation
US11413458B2 (en) 2011-05-19 2022-08-16 Neuros Medical, Inc. Nerve cuff electrode for neuromodulation in large human nerve trunks
US10390877B2 (en) 2011-12-30 2019-08-27 Relievant Medsystems, Inc. Systems and methods for treating back pain
US9254379B2 (en) 2012-01-30 2016-02-09 University Of Iowa Research Foundation System that secures an electrode array to the spinal cord for treating back pain
CN104203338B (zh) * 2012-01-30 2017-09-08 艾奥华大学研究基金会 用于刺激脊髓以抑制疼痛传输的装置和系统
US10588691B2 (en) 2012-09-12 2020-03-17 Relievant Medsystems, Inc. Radiofrequency ablation of tissue within a vertebral body
AU2013337680B2 (en) 2012-11-05 2019-04-18 Relievant Medsystems, Inc. Systems and methods for creating curved paths through bone and modulating nerves within the bone
US20140277267A1 (en) 2013-03-15 2014-09-18 Boston Scientific Neuromodulation Corporation Neuromodulation system and method for transitioning between programming modes
EP2968932B1 (en) * 2013-03-15 2017-10-18 Boston Scientific Neuromodulation Corporation Neuromodulation system for providing multiple modulation patterns in a single channel
US9895539B1 (en) 2013-06-10 2018-02-20 Nevro Corp. Methods and systems for disease treatment using electrical stimulation
US9724151B2 (en) 2013-08-08 2017-08-08 Relievant Medsystems, Inc. Modulating nerves within bone using bone fasteners
US9358384B2 (en) * 2014-09-05 2016-06-07 Advanced Neuromodulation Systems, Inc. Implantable lead with flexible paddle electrode array
US9956404B2 (en) 2014-11-19 2018-05-01 Medtronic, Inc. Electrical stimulation to inhibit bladder and/or bowel contraction
WO2016209682A1 (en) 2015-06-23 2016-12-29 Duke University Systems and methods for utilizing model-based optimization of spinal cord stimulation parameters
US9630012B2 (en) 2015-08-06 2017-04-25 Meagan Medical, Inc. Spinal cord stimulation with interferential current
WO2017035140A1 (en) * 2015-08-26 2017-03-02 Boston Scientific Neuromodulation Corporation Machine learning to optimize spinal cord stimulation
EP3389768B1 (en) 2015-12-18 2023-03-01 Medtronic, Inc. High duty cycle electrical stimulation therapy
US10799701B2 (en) * 2016-03-30 2020-10-13 Nevro Corp. Systems and methods for identifying and treating patients with high-frequency electrical signals
US11446504B1 (en) 2016-05-27 2022-09-20 Nevro Corp. High frequency electromagnetic stimulation for modulating cells, including spontaneously active and quiescent cells, and associated systems and methods
WO2018039117A1 (en) 2016-08-22 2018-03-01 Boston Scientific Neuromodulation Corporation Neuromodulation system for providing paresthesia and analgesia and a system with leads and with electrodes
US10525268B2 (en) 2016-08-23 2020-01-07 Medtronic, Inc. Delivery of independent interleaved programs to produce higher-frequency electrical stimulation therapy
US11426577B2 (en) 2016-08-26 2022-08-30 Wisconsin Alumni Research Foundation Neuromodulation to modulate glymphatic clearance
US10569088B2 (en) 2016-09-16 2020-02-25 Medtronic, Inc. Dorsal spinal column characterization with evoked potentials
US11071863B2 (en) 2016-10-28 2021-07-27 Medtronic, Inc. Controlling electrical stimulation therapy
US11045650B2 (en) 2016-12-06 2021-06-29 Medtronic, Inc. High frequency neurostimulation for pelvic symptom control
US20180272132A1 (en) 2017-01-19 2018-09-27 Nevro Corp. High frequency stimulation for treating sensory and/or motor deficits in patients with spinal cord injuries and/or peripheral polyneuropathy, and associated systems and methods
CN110418664B (zh) 2017-04-07 2024-03-19 美敦力公司 电刺激治疗参数的复杂变化
US10065791B1 (en) * 2017-10-09 2018-09-04 Jeffrey B. Charles Aerosol applicator system having user configurable spray direction
US10987515B2 (en) 2017-10-10 2021-04-27 Medtronic, Inc. Management of electrical stimulation therapy
AU2018385603B2 (en) 2017-12-13 2024-05-02 Neuros Medical, Inc. Nerve cuff deployment devices
WO2019199558A1 (en) 2018-04-09 2019-10-17 Neuros Medical, Inc. Apparatuses and methods for setting an electrical dose
CN112867532A (zh) * 2018-06-01 2021-05-28 艾奥华大学研究基金会 用于刺激脊髓的经硬膜电极装置
CN119951005A (zh) 2018-06-21 2025-05-09 美敦力公司 电刺激治疗的基于ecap的控制
CN112351813B (zh) 2018-06-21 2024-12-17 美敦力公司 电刺激治疗的基于ecap的控制
WO2020150647A1 (en) 2019-01-17 2020-07-23 Nevro Corp. Sensory threshold and/or adaptation for neurological therapy screening and/or parameter selection, and associated systems and methods
US11590352B2 (en) 2019-01-29 2023-02-28 Nevro Corp. Ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods
WO2021050767A1 (en) 2019-09-12 2021-03-18 Relievant Medsystems, Inc. Systems and methods for tissue modulation
US11931582B2 (en) 2019-10-25 2024-03-19 Medtronic, Inc. Managing transient overstimulation based on ECAPs
US12357830B2 (en) 2019-10-25 2025-07-15 Medtronic, Inc. Sub-threshold stimulation based on ECAP detection
US11547855B2 (en) 2019-10-25 2023-01-10 Medtronic, Inc. ECAP sensing for high frequency neurostimulation
US11382512B2 (en) 2020-01-03 2022-07-12 Warsaw Orthopedic, Inc. Energy transfer system for spinal implants
US11517398B2 (en) * 2020-01-03 2022-12-06 Warsaw Orthopedic, Inc. Energy transfer system for spinal implants
US11878172B2 (en) 2020-02-11 2024-01-23 Neuros Medical, Inc. System and method for quantifying qualitative patient-reported data sets
US12128235B2 (en) 2020-03-06 2024-10-29 Medtronic, Inc. Controlling electrical stimulation based on a sensed stimulation signal
US12097373B2 (en) 2020-06-10 2024-09-24 Medtronic, Inc. Control policy settings for electrical stimulation therapy
US11857793B2 (en) 2020-06-10 2024-01-02 Medtronic, Inc. Managing storage of sensed information
AU2021306313A1 (en) 2020-07-10 2023-03-02 Relievant Medsystems, Inc. Vertebral denervation in conjunction with vertebral fusion
US20220062635A1 (en) * 2020-08-25 2022-03-03 Peyman Nazmi Neuromodulators and method of programming thereof
US11707626B2 (en) 2020-09-02 2023-07-25 Medtronic, Inc. Analyzing ECAP signals
US12082876B1 (en) 2020-09-28 2024-09-10 Relievant Medsystems, Inc. Introducer drill
US11896828B2 (en) 2020-10-30 2024-02-13 Medtronic, Inc. Implantable lead location using ECAP
EP4268150A4 (en) 2020-12-22 2024-12-18 Relievant Medsystems, Inc. PREDICTION OF CANDIDATES FOR SPINAL CORD NEUROMODULATION
CN112909539B (zh) * 2021-01-20 2022-02-22 西安交通大学 一种毫米波频率极化双随机多端口聚束天线
CN112843470B (zh) * 2021-02-05 2025-02-28 杭州诺为医疗技术有限公司 一种植入式闭环刺激方法和装置
US12433668B1 (en) 2021-11-08 2025-10-07 Relievant Medsystems, Inc. Impedance stoppage mitigation during radiofrequency tissue ablation procedures
CN116271516B (zh) * 2023-03-29 2023-11-14 中国人民解放军军事科学院军事医学研究院 一种脊髓硬膜外植入多模式贴片电极
CN117883097A (zh) * 2024-02-29 2024-04-16 首都医科大学宣武医院 一种脊髓电信号采集装置、方法和系统
CN119236307B (zh) * 2024-12-04 2025-04-15 首都医科大学宣武医院 一种植入式选择性脊神经根刺激系统
CN119701206B (zh) * 2025-02-26 2025-07-25 中国人民解放军总医院第一医学中心 硬膜外电刺激装置

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3612061A (en) 1969-02-20 1971-10-12 Inst Of Medical Sciences The Flexible cutaneous electrode matrix
US3724467A (en) 1971-04-23 1973-04-03 Avery Labor Inc Electrode implant for the neuro-stimulation of the spinal cord
US3822708A (en) 1972-12-07 1974-07-09 Clinical Technology Corp Electrical spinal cord stimulating device and method for management of pain
US4549556A (en) 1982-12-08 1985-10-29 Cordis Corporation Implantable lead
US4590946A (en) 1984-06-14 1986-05-27 Biomed Concepts, Inc. Surgically implantable electrode for nerve bundles
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
US5542946A (en) 1994-05-27 1996-08-06 Sofamor S.N.C. Hook for an occipito-cervical rod or plate of an occipito-cervical osteosynthesis instrumentation
US6078838A (en) 1998-02-13 2000-06-20 University Of Iowa Research Foundation Pseudospontaneous neural stimulation system and method
US6631295B2 (en) 1998-02-13 2003-10-07 University Of Iowa Research Foundation System and method for diagnosing and/or reducing tinnitus
US6319241B1 (en) * 1998-04-30 2001-11-20 Medtronic, Inc. Techniques for positioning therapy delivery elements within a spinal cord or a brain
US6175769B1 (en) 1999-06-14 2001-01-16 Electro Core Technologies, Llc Spinal cord electrode assembly having laterally extending portions
US6549810B1 (en) 1999-12-01 2003-04-15 Vertis Neuroscience, Inc. Percutaneous electrical therapy system with electrode depth control
US20040176831A1 (en) 2000-07-13 2004-09-09 Gliner Bradford Evan Apparatuses and systems for applying electrical stimulation to a patient
US6546293B2 (en) 2001-02-15 2003-04-08 Electro Core Technologies, Llc Hook-shaped spinal cord electrode assembly having a telescoping electrode
JP2002301038A (ja) * 2001-04-05 2002-10-15 Techno Network Shikoku Co Ltd 硬膜下電極
US6928320B2 (en) * 2001-05-17 2005-08-09 Medtronic, Inc. Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated
US8295945B1 (en) 2001-05-29 2012-10-23 Boston Scientific Neuromodulation Corporation Neural stimulation lead fixation
US7263402B2 (en) 2001-08-13 2007-08-28 Advanced Bionics Corporation System and method of rapid, comfortable parameter switching in spinal cord stimulation
JP2005515851A (ja) 2002-02-01 2005-06-02 ザ クリーヴランド クリニック ファウンデーション 調整可能な刺激装置およびその使用方法
US7697995B2 (en) * 2002-04-25 2010-04-13 Medtronic, Inc. Surgical lead paddle
US7333857B2 (en) 2003-07-18 2008-02-19 Arcl, Inc. Treatment of pain
WO2005087314A1 (en) * 2004-03-11 2005-09-22 Advanced Neuromodulation Systems, Inc. Brain stimulation system and method
US20060052856A1 (en) 2004-09-08 2006-03-09 Kim Daniel H Stimulation components
US20070060954A1 (en) 2005-02-25 2007-03-15 Tracy Cameron Method of using spinal cord stimulation to treat neurological disorders or conditions
US8644941B2 (en) 2005-06-09 2014-02-04 Medtronic, Inc. Peripheral nerve field stimulation and spinal cord stimulation
US7769472B2 (en) 2005-07-29 2010-08-03 Medtronic, Inc. Electrical stimulation lead with conformable array of electrodes
JP2009521276A (ja) 2005-12-22 2009-06-04 プロテウス バイオメディカル インコーポレイテッド 植え込み型集積回路
US20100057178A1 (en) * 2006-04-18 2010-03-04 Electrocore, Inc. Methods and apparatus for spinal cord stimulation using expandable electrode
US20080234791A1 (en) * 2007-01-17 2008-09-25 Jeffrey Edward Arle Spinal cord implant systems and methods
US8224453B2 (en) * 2007-03-15 2012-07-17 Advanced Neuromodulation Systems, Inc. Spinal cord stimulation to treat pain
US9717910B2 (en) 2008-09-04 2017-08-01 Boston Scientific Neuromodulation Corporation Multiple tunable central cathodes on a paddle for increased medial-lateral and rostral-caudal flexibility via current steering
US20100063568A1 (en) 2008-09-11 2010-03-11 Staunton Douglas A Implantable electrode array assembly with extraction sleeve/tether
GB2476219B (en) 2008-10-22 2013-01-02 Advanced Neuromodulation Sys Method for processing electrodes for stimulation lead
US8255057B2 (en) 2009-01-29 2012-08-28 Nevro Corporation Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions
EP2243510B1 (en) 2009-04-22 2014-04-09 Nevro Corporation Sytems for selective high frequency spinal cord modulation for inhibiting pain with reduced side effects
US9364660B2 (en) * 2010-11-11 2016-06-14 University Of Iowa Research Foundation Electrode array device configured for placement inside the dura for direct spinal cord stimulation
AU2011336606B2 (en) 2010-11-30 2016-06-23 Nevro Corporation Extended pain relief via high frequency spinal cord modulation, and associated systems and methods
US9789313B2 (en) * 2011-02-23 2017-10-17 John D. LIPANI System and methods for diagnosis and treatment of discogenic lower back pain
CN104203338B (zh) 2012-01-30 2017-09-08 艾奥华大学研究基金会 用于刺激脊髓以抑制疼痛传输的装置和系统
US9254379B2 (en) 2012-01-30 2016-02-09 University Of Iowa Research Foundation System that secures an electrode array to the spinal cord for treating back pain

Also Published As

Publication number Publication date
JP2015504769A (ja) 2015-02-16
EP2809389A1 (en) 2014-12-10
US9950165B2 (en) 2018-04-24
US9403008B2 (en) 2016-08-02
EP2809389B1 (en) 2017-05-24
CN104203338A (zh) 2014-12-10
US20140379043A1 (en) 2014-12-25
JP6196634B2 (ja) 2017-09-13
HK1203869A1 (en) 2015-11-06
US20170028201A1 (en) 2017-02-02
WO2013116368A1 (en) 2013-08-08
CN104203338B (zh) 2017-09-08
EP2809389A4 (en) 2015-10-28

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