CA2860953C - Dispositif et procede de manipulation de tissus biologiques - Google Patents
Dispositif et procede de manipulation de tissus biologiques Download PDFInfo
- Publication number
- CA2860953C CA2860953C CA2860953A CA2860953A CA2860953C CA 2860953 C CA2860953 C CA 2860953C CA 2860953 A CA2860953 A CA 2860953A CA 2860953 A CA2860953 A CA 2860953A CA 2860953 C CA2860953 C CA 2860953C
- Authority
- CA
- Canada
- Prior art keywords
- sample
- cassette
- tissue
- lever
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title description 56
- 238000001574 biopsy Methods 0.000 claims description 185
- 238000003384 imaging method Methods 0.000 claims description 9
- 239000000523 sample Substances 0.000 description 622
- 210000001519 tissue Anatomy 0.000 description 412
- 238000004043 dyeing Methods 0.000 description 66
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 29
- 238000003825 pressing Methods 0.000 description 22
- 239000002184 metal Substances 0.000 description 21
- 239000012188 paraffin wax Substances 0.000 description 21
- 210000000056 organ Anatomy 0.000 description 18
- 238000002360 preparation method Methods 0.000 description 15
- 239000000975 dye Substances 0.000 description 13
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 12
- 239000011521 glass Substances 0.000 description 11
- 201000010099 disease Diseases 0.000 description 10
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- 206010028980 Neoplasm Diseases 0.000 description 8
- 238000006073 displacement reaction Methods 0.000 description 8
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- 229920003266 Leaf® Polymers 0.000 description 6
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- 230000002596 correlated effect Effects 0.000 description 5
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- 210000002307 prostate Anatomy 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 229920002678 cellulose Polymers 0.000 description 4
- 238000004040 coloring Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 241000397426 Centroberyx lineatus Species 0.000 description 3
- 238000005452 bending Methods 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000001311 chemical methods and process Methods 0.000 description 3
- 238000007654 immersion Methods 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010060862 Prostate cancer Diseases 0.000 description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
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- 238000012986 modification Methods 0.000 description 2
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- 238000009877 rendering Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000012993 chemical processing Methods 0.000 description 1
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- 239000003292 glue Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
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- 238000002791 soaking Methods 0.000 description 1
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- 230000001954 sterilising effect Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
- A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0096—Casings for storing test samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/2833—Collecting samples on a sticky, tacky, adhesive surface
Abstract
La présente invention concerne un dispositif de manipulation de tissus. Elle concerne également un dispositif de collecte de tissus. Elle concerne aussi une cassette permettant de manipuler des tissus biologiques. Elle concerne aussi un dispositif de coloration de tissu. Elle concerne aussi un procédé permettant de manipuler des tissus biologiques. En outre, elle concerne un procédé permettant de colorer des tissus biologiques.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2912210A CA2912210C (fr) | 2012-01-10 | 2013-01-10 | Dispositif et procede de manipulation de tissus biologiques |
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261584833P | 2012-01-10 | 2012-01-10 | |
US61/584,833 | 2012-01-10 | ||
US201261590932P | 2012-01-26 | 2012-01-26 | |
US61/590,932 | 2012-01-26 | ||
US201261694270P | 2012-08-29 | 2012-08-29 | |
US61/694,270 | 2012-08-29 | ||
US201261706042P | 2012-09-26 | 2012-09-26 | |
US61/706,042 | 2012-09-26 | ||
PCT/IL2013/050031 WO2013105095A1 (fr) | 2012-01-10 | 2013-01-10 | Dispositif et procédé de manipulation de tissus biologiques |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2912210A Division CA2912210C (fr) | 2012-01-10 | 2013-01-10 | Dispositif et procede de manipulation de tissus biologiques |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2860953A1 CA2860953A1 (fr) | 2013-07-18 |
CA2860953C true CA2860953C (fr) | 2015-12-29 |
Family
ID=48781102
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2860953A Active CA2860953C (fr) | 2012-01-10 | 2013-01-10 | Dispositif et procede de manipulation de tissus biologiques |
CA2912210A Active CA2912210C (fr) | 2012-01-10 | 2013-01-10 | Dispositif et procede de manipulation de tissus biologiques |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2912210A Active CA2912210C (fr) | 2012-01-10 | 2013-01-10 | Dispositif et procede de manipulation de tissus biologiques |
Country Status (6)
Country | Link |
---|---|
US (3) | US9341551B2 (fr) |
EP (1) | EP2802881A4 (fr) |
JP (2) | JP5918862B2 (fr) |
CA (2) | CA2860953C (fr) |
IN (1) | IN2014MN01614A (fr) |
WO (1) | WO2013105095A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9892557B2 (en) | 2012-01-26 | 2018-02-13 | Uc-Care Ltd. | Integrated system for focused treatment and methods thereof |
EP2932230B1 (fr) | 2012-12-17 | 2020-02-05 | UC-Care Ltd. | Appareil de moulage pour intégrer un spécimen biologique dans un bloc et méthode associée |
EP2967424B1 (fr) | 2013-03-15 | 2021-09-01 | UC-Care Ltd. | Système et procédés pour traiter un échantillon de biopsie |
JP6565198B2 (ja) * | 2015-02-04 | 2019-08-28 | Mccアドバンスドモールディングス株式会社 | 医療検体保持部材及び医療検体保持部材アッセンブリ |
EP3454760B1 (fr) | 2016-05-10 | 2020-04-22 | Koninklijke Philips N.V. | Récipient de biopsie |
US11733130B2 (en) * | 2016-10-07 | 2023-08-22 | Umihira Co., Ltd. | Tissue dividing jig |
GB2571051A (en) * | 2016-10-11 | 2019-08-14 | Synaptive Medical Barbados Inc | Biopsy cassette for multi-modality cross-system data correlation |
WO2018087367A2 (fr) * | 2016-11-12 | 2018-05-17 | Teesuvac Aps | Dispositif de prélèvement de tissu permettant de prélever un ou plusieurs échantillons de tissu à partir d'une aiguille de biopsie ou d'un dispositif de biopsie, et dispositif de biopsie comprenant un tel dispositif de prélèvement de tissu |
FR3063630B1 (fr) * | 2017-03-08 | 2021-11-12 | Univ Grenoble Alpes | Support pour un echantillon d’especes biologiques |
EP3578111A1 (fr) | 2018-06-04 | 2019-12-11 | TeesuVac ApS | Dispositif de collecte de tissus pour la collecte d'échantillons de tissus à partir d'une aiguille de biopsie et dispositif de biopsie comprenant un dispositif de collecte de tissus |
JP6984922B2 (ja) * | 2018-06-05 | 2021-12-22 | 国立研究開発法人海洋研究開発機構 | バイオプシーデバイス、該バイオプシーデバイスを射出するための射出装置、及び、これらを備えたバイオプシー装置 |
WO2020118378A1 (fr) * | 2018-12-14 | 2020-06-18 | Leica Biosystems Melbourne Pty Ltd | Cassette de réactifs |
WO2023184382A1 (fr) * | 2022-03-31 | 2023-10-05 | Leica Biosystems Nussloch Gmbh | Dispositif de pressage d'une cassette et dispositif d'incorporation le comprenant |
WO2023228040A1 (fr) * | 2022-05-23 | 2023-11-30 | Uc-Care Ltd. | Dispositif et procédé de collecte d'échantillons biologiques à partir d'un faisceau |
Family Cites Families (42)
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US2732581A (en) | 1956-01-31 | Hinge structure for molded plastic boxes | ||
US4738664A (en) | 1987-04-20 | 1988-04-19 | Ideal Instruments, Inc. | Pistol grip syringe |
US4929426A (en) | 1987-11-02 | 1990-05-29 | Biologix, Inc. | Portable blood chemistry measuring apparatus |
US5612218A (en) | 1991-12-03 | 1997-03-18 | Busch; Christer | Method of handling biologic matter and means for carrying out the method |
US5526822A (en) * | 1994-03-24 | 1996-06-18 | Biopsys Medical, Inc. | Method and apparatus for automated biopsy and collection of soft tissue |
US5649547A (en) | 1994-03-24 | 1997-07-22 | Biopsys Medical, Inc. | Methods and devices for automated biopsy and collection of soft tissue |
US5817032A (en) | 1996-05-14 | 1998-10-06 | Biopath Automation Llc. | Means and method for harvesting and handling tissue samples for biopsy analysis |
JP3776246B2 (ja) | 1998-12-02 | 2006-05-17 | 富士写真フイルム株式会社 | 画像情報読取装置に使用される試料台およびその製造方法 |
US6364866B1 (en) | 1999-01-22 | 2002-04-02 | Douglas Furr | Syringe loading aid |
JP2002537579A (ja) * | 1999-02-17 | 2002-11-05 | ルーシド インコーポレーテッド | 組織検体ホルダ |
US6395234B1 (en) | 2000-02-08 | 2002-05-28 | Triangle Biomedical Sciences, Inc. | Sample cassette having utility for histological processing of tissue samples |
US6439276B1 (en) * | 2001-07-06 | 2002-08-27 | Trimensions, Inc. | Kit for loading and disposal of hypodermic syringes used for administering medication |
US6719691B2 (en) | 2001-07-26 | 2004-04-13 | Common Sense Ltd. | Method, device and kit for obtaining biological samples |
WO2003020333A2 (fr) | 2001-08-29 | 2003-03-13 | Artemis Medical, Inc. | Procede et ensemble de prelevement de tissu intact |
WO2003031064A1 (fr) | 2001-10-12 | 2003-04-17 | Becton, Dickinson And Company | Procede et appareil permettant de transporter des echantillons biologiques |
ATE329246T1 (de) | 2002-02-14 | 2006-06-15 | Daniel Dr Studer | Vorrichtung zur behandlung von biopsieproben sowie verfahren zu deren verwendung |
ATE303099T1 (de) | 2002-03-19 | 2005-09-15 | Bard Dublin Itc Ltd | Vakuum-biopsievorrichtung |
US7229820B2 (en) | 2002-06-13 | 2007-06-12 | Wilson Wolf Manufacturing Corporation | Apparatus and method for culturing and preserving tissue constructs |
US7179424B2 (en) | 2002-09-26 | 2007-02-20 | Biopath Automation, L.L.C. | Cassette for handling and holding tissue samples during processing, embedding and microtome procedures, and methods therefor |
EP1545775B1 (fr) | 2002-09-26 | 2010-06-16 | BioPath Automation, L.L.C. | Cassette et ensemble d'incorporation, dispositifs de stadification, et procedes de manipulation d'echantillons de tissu |
US7521021B2 (en) | 2003-11-26 | 2009-04-21 | Leica Biosvstems St. Louis Llc | System for in situ processing of a tissue specimen |
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JP5137481B2 (ja) | 2007-06-29 | 2013-02-06 | オリンパス株式会社 | 画像処理装置、画像処理プログラム、および画像処理方法 |
US7798331B2 (en) * | 2007-08-20 | 2010-09-21 | Suros Surgical Systems, Inc. | Tissue collection tray |
CA2703526A1 (fr) | 2007-10-23 | 2009-04-30 | Lotus Bio (Nymphaea) Ltd. | Dispositif pour dosage biologique d'echantillon biologique |
EP3450954B1 (fr) * | 2007-12-10 | 2020-09-02 | Agilent Technologies, Inc. | Appareil de traitement de tissus |
US20100075410A1 (en) | 2008-09-20 | 2010-03-25 | Virendra Desai | Reusable Tissue Biopsy Kit with Padded Cassette |
US8622927B2 (en) * | 2008-12-18 | 2014-01-07 | Devicor Medical Products, Inc. | Mechanical tissue sample holder indexing device |
DK2389116T3 (en) | 2009-01-22 | 2018-02-12 | Biopath Automation Llc | BIOPSY SUPPORT TO ORIENT TESTS FOR SECTION IN A MICROTOM |
US8485989B2 (en) | 2009-09-01 | 2013-07-16 | Bard Peripheral Vascular, Inc. | Biopsy apparatus having a tissue sample retrieval mechanism |
US8535239B2 (en) | 2010-05-11 | 2013-09-17 | Ethicon Endo-Surgery, Inc. | Tissue harvesting device with manual dicing mechanism |
US8468891B2 (en) | 2010-05-12 | 2013-06-25 | Ethicon Endo-Surgery, Inc. | Tissue processing device with ultrasonic measuring chamber |
US9392960B2 (en) | 2010-06-24 | 2016-07-19 | Uc-Care Ltd. | Focused prostate cancer treatment system and method |
-
2013
- 2013-01-10 US US14/370,645 patent/US9341551B2/en active Active
- 2013-01-10 EP EP13736175.4A patent/EP2802881A4/fr active Pending
- 2013-01-10 IN IN1614MUN2014 patent/IN2014MN01614A/en unknown
- 2013-01-10 WO PCT/IL2013/050031 patent/WO2013105095A1/fr active Application Filing
- 2013-01-10 CA CA2860953A patent/CA2860953C/fr active Active
- 2013-01-10 JP JP2014551727A patent/JP5918862B2/ja active Active
- 2013-01-10 CA CA2912210A patent/CA2912210C/fr active Active
- 2013-07-30 US US13/954,638 patent/US20140031718A1/en not_active Abandoned
-
2016
- 2016-04-08 JP JP2016078068A patent/JP6255441B2/ja active Active
- 2016-05-03 US US15/145,535 patent/US10383607B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2802881A1 (fr) | 2014-11-19 |
WO2013105095A1 (fr) | 2013-07-18 |
US20140377148A1 (en) | 2014-12-25 |
CA2860953A1 (fr) | 2013-07-18 |
WO2013105095A8 (fr) | 2013-10-10 |
EP2802881A4 (fr) | 2015-01-07 |
JP5918862B2 (ja) | 2016-05-18 |
JP6255441B2 (ja) | 2017-12-27 |
US10383607B2 (en) | 2019-08-20 |
US20160242748A1 (en) | 2016-08-25 |
CA2912210C (fr) | 2018-06-26 |
IN2014MN01614A (fr) | 2015-05-15 |
US9341551B2 (en) | 2016-05-17 |
CA2912210A1 (fr) | 2013-07-18 |
US20140031718A1 (en) | 2014-01-30 |
JP2015506745A (ja) | 2015-03-05 |
JP2016148675A (ja) | 2016-08-18 |
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