CA2856461C - Nt-proanp and nt-probnp for the diagnosis of stroke - Google Patents

Nt-proanp and nt-probnp for the diagnosis of stroke Download PDF

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Publication number
CA2856461C
CA2856461C CA2856461A CA2856461A CA2856461C CA 2856461 C CA2856461 C CA 2856461C CA 2856461 A CA2856461 A CA 2856461A CA 2856461 A CA2856461 A CA 2856461A CA 2856461 C CA2856461 C CA 2856461C
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subject
sample
tia
amount
proanp
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CA2856461A
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English (en)
French (fr)
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CA2856461A1 (en
Inventor
Georg Hess
Andrea Horsch
Dietmar Zdunek
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Priority to CA3081979A priority Critical patent/CA3081979C/en
Publication of CA2856461A1 publication Critical patent/CA2856461A1/en
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Publication of CA2856461C publication Critical patent/CA2856461C/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575Hormones
    • G01N2333/58Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2871Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/50Determining the risk of developing a disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2856461A 2011-12-01 2012-11-29 Nt-proanp and nt-probnp for the diagnosis of stroke Active CA2856461C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3081979A CA3081979C (en) 2011-12-01 2012-11-29 Nt-proanp and nt-probnp for the diagnosis of stroke

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11191579.9 2011-12-01
EP11191579 2011-12-01
PCT/EP2012/073897 WO2013079567A2 (en) 2011-12-01 2012-11-29 Nt-proanp and nt-probnp for the diagnosis of stroke

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3081979A Division CA3081979C (en) 2011-12-01 2012-11-29 Nt-proanp and nt-probnp for the diagnosis of stroke

Publications (2)

Publication Number Publication Date
CA2856461A1 CA2856461A1 (en) 2013-06-06
CA2856461C true CA2856461C (en) 2020-08-18

Family

ID=47278813

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2856461A Active CA2856461C (en) 2011-12-01 2012-11-29 Nt-proanp and nt-probnp for the diagnosis of stroke
CA3081979A Active CA3081979C (en) 2011-12-01 2012-11-29 Nt-proanp and nt-probnp for the diagnosis of stroke

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3081979A Active CA3081979C (en) 2011-12-01 2012-11-29 Nt-proanp and nt-probnp for the diagnosis of stroke

Country Status (7)

Country Link
US (2) US10732188B2 (enExample)
EP (2) EP3290924B1 (enExample)
JP (2) JP6059735B2 (enExample)
CN (2) CN107064516B (enExample)
CA (2) CA2856461C (enExample)
ES (2) ES2899923T3 (enExample)
WO (1) WO2013079567A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016056664A1 (ja) * 2014-10-10 2016-04-14 松森 昭 心不全患者の検出方法、心疾患の識別方法、心不全の検査試薬、心不全の検査キット、心不全を検出するための装置及び心不全を検出するためのプログラム
BR112021001798A2 (pt) * 2018-07-31 2021-04-27 F. Hoffmann-La Roche Ag métodos para avaliar a fibrilação atrial, para diagnosticar insuficiência cardíaca, para auxiliar na avaliação da fibrilação atrial, para prever o risco de acidente vascular cerebral e para aprimorar a precisão da previsão, usos e kit
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
US12400762B2 (en) 2018-12-11 2025-08-26 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views
JP7698310B2 (ja) * 2019-05-16 2025-06-25 フンダシオ オスピタル ウニベルシタリ バル デブロン-インスティテュート デ レセルカ 再灌流療法のために患者を選択する方法
JP2021173559A (ja) 2020-04-21 2021-11-01 株式会社デンソー 物理量計測装置

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
GB9211686D0 (en) 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
WO2003016910A1 (en) 2001-08-20 2003-02-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7632647B2 (en) 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
DE60233301D1 (de) 2001-05-04 2009-09-24 Biosite Inc Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs
WO2004059293A2 (en) * 2002-12-24 2004-07-15 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US7517951B2 (en) * 2002-12-24 2009-04-14 Nitto Boseki Co., Ltd. Marker proteins for diagnosing liver disease and method of diagnosing liver disease using the same
US20050181386A1 (en) * 2003-09-23 2005-08-18 Cornelius Diamond Diagnostic markers of cardiovascular illness and methods of use thereof
EP1582597A1 (en) 2004-03-29 2005-10-05 Aventis Pharma Deutschland GmbH Method of diagnosis of a predisposition to develop thrombotic disease and its uses
US20060166303A1 (en) * 2005-01-24 2006-07-27 Eberhard Spanuth Use of cardiac hormones for assessing a cardiovascular risk with respect to the administration of anti-inflammatory drugs
WO2006077265A1 (en) 2005-01-24 2006-07-27 F. Hoffmann-La Roche Ag The use of bnp-type peptides and anp-type peptides for assessing the risk of suffering from a cardiovascular complication as a consequence of volume overload
JP4828550B2 (ja) * 2005-02-17 2011-11-30 エフ.ホフマン−ラ ロシュ アーゲー 心機能障害を診断するためのNT−proANP/NT−proBNP比の使用
EP1731910A1 (en) * 2005-06-07 2006-12-13 F. Hoffmann-La Roche Ag Use of NT-proANP and NT-proBNP for diagnosing cardiac diseases
DE102005048899A1 (de) * 2005-10-12 2007-04-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Diagnose thromboembolischer Erkrankungen und koronarer Herzerkrankungen
DE602006014798D1 (de) 2006-03-24 2010-07-22 Roche Diagnostics Gmbh Vorrichtung und Verfahren zur Unterscheidung zwischen akuter und chronischer Myokardial-Nekrose bei symptomatischen Patienten
EP1882945A1 (en) * 2006-07-28 2008-01-30 F.Hoffmann-La Roche Ag Means and methods for the differentiation of cardiac and pulmonary causes of acute shortness of breath
DE602006010705D1 (de) * 2006-09-15 2010-01-07 Roche Diagnostics Gmbh Biochemische Marker für akute Lungenembolie
WO2009047285A1 (en) 2007-10-10 2009-04-16 Roche Diagnostics Gmbh Natriuretic peptide/troponin ratio for the assessment of preexisting myocardial dysfunction in patients with acute coronary syndrome
EP2356450B1 (en) * 2008-10-24 2019-02-06 B.R.A.H.M.S GmbH Prognosis and risk assessment in stroke patients by determining the level of marker peptides
AU2009339152B2 (en) * 2009-01-30 2015-11-19 Bio-Rad Europe Gmbh Method for the in vitro diagnosis of stroke
EP2466311A1 (en) 2010-12-17 2012-06-20 Roche Diagnostics GmbH sFlt1 in patients with ischemic stroke

Also Published As

Publication number Publication date
CN104094121A (zh) 2014-10-08
CA3081979A1 (en) 2013-06-06
EP2786154B1 (en) 2017-11-01
HK1201327A1 (en) 2015-08-28
CN104094121B (zh) 2016-10-26
JP6059735B2 (ja) 2017-01-11
US20200333360A1 (en) 2020-10-22
WO2013079567A3 (en) 2013-08-29
WO2013079567A2 (en) 2013-06-06
EP2786154A2 (en) 2014-10-08
US20140274793A1 (en) 2014-09-18
EP3290924B1 (en) 2021-10-13
JP6441885B2 (ja) 2018-12-19
CN107064516A (zh) 2017-08-18
EP3290924A1 (en) 2018-03-07
ES2899923T3 (es) 2022-03-15
US10732188B2 (en) 2020-08-04
ES2656082T3 (es) 2018-02-23
JP2017075959A (ja) 2017-04-20
JP2015504519A (ja) 2015-02-12
CA3081979C (en) 2023-07-11
CA2856461A1 (en) 2013-06-06
CN107064516B (zh) 2019-08-02

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Effective date: 20140521