CA2854422A1 - Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment - Google Patents
Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment Download PDFInfo
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- CA2854422A1 CA2854422A1 CA2854422A CA2854422A CA2854422A1 CA 2854422 A1 CA2854422 A1 CA 2854422A1 CA 2854422 A CA2854422 A CA 2854422A CA 2854422 A CA2854422 A CA 2854422A CA 2854422 A1 CA2854422 A1 CA 2854422A1
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- lipid
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Classifications
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
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- H—ELECTRICITY
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- G—PHYSICS
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
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- G—PHYSICS
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- G—PHYSICS
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- G01N2800/50—Determining the risk of developing a disease
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- G—PHYSICS
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Landscapes
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- Engineering & Computer Science (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161556915P | 2011-11-08 | 2011-11-08 | |
| US61/556,915 | 2011-11-08 | ||
| EP11188325.2A EP2592422A1 (en) | 2011-11-08 | 2011-11-08 | Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment |
| EP11188325.2 | 2011-11-08 | ||
| PCT/EP2012/071973 WO2013068374A2 (en) | 2011-11-08 | 2012-11-07 | Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment |
Publications (1)
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| CA2854422A1 true CA2854422A1 (en) | 2013-05-16 |
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Family Applications (1)
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| CA2854422A Abandoned CA2854422A1 (en) | 2011-11-08 | 2012-11-07 | Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment |
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| EP (2) | EP2592422A1 (https=) |
| JP (1) | JP6388284B2 (https=) |
| CN (1) | CN104024860B (https=) |
| CA (1) | CA2854422A1 (https=) |
| HK (1) | HK1202154A1 (https=) |
| WO (1) | WO2013068374A2 (https=) |
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| US9806270B2 (en) | 2011-03-25 | 2017-10-31 | Udc Ireland Limited | 4H-imidazo[1,2-a]imidazoles for electronic applications |
| EP2592423A1 (en) | 2011-11-08 | 2013-05-15 | Zora Biosciences OY | Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients not undergoing statin treatment |
| KR102021099B1 (ko) | 2011-11-10 | 2019-09-16 | 유디씨 아일랜드 리미티드 | 전자장치 응용을 위한 4h-이미다조[1,2-a]이미다졸 |
| ES2552371T3 (es) * | 2012-05-25 | 2015-11-27 | Zora Biosciences Oy | Biomarcadores sensibles, eficaces e inocuos, para la inhibición de la Proproteína Convertasa Subtilisina/Kexina de tipo 9 (PCSK9) |
| EP2872512B1 (en) | 2012-07-10 | 2017-05-10 | UDC Ireland Limited | Benzimidazo[1,2-a]benzimidazole derivatives for electronic applications |
| CN106457090B (zh) | 2014-04-10 | 2020-09-29 | Mep马解决方案有限责任公司 | 粪便中寄生虫卵的定量方法 |
| US9347960B2 (en) | 2014-06-16 | 2016-05-24 | Zora Biosciences, Oy | Ceramides and their use in diagnosing CVD |
| WO2016100549A2 (en) * | 2014-12-16 | 2016-06-23 | Washington University | Ceramides for evaluating risk of cardiovascular disease |
| US10184932B2 (en) | 2015-12-07 | 2019-01-22 | Zora Biosciences Oy | Use of ceramides and LPLs in diagnosing CVD |
| CN105628809B (zh) * | 2015-12-25 | 2018-04-03 | 中国药科大学 | 用于诊断区分冠状动脉粥样硬化和冠心病的代谢标志物 |
| CN105486773A (zh) * | 2015-12-25 | 2016-04-13 | 齐炼文 | 用于诊断冠心病的代谢标志物 |
| CN105424841B (zh) * | 2015-12-25 | 2017-11-03 | 齐炼文 | 用于诊断冠状动脉粥样硬化的代谢标志物 |
| KR102003309B1 (ko) * | 2016-12-05 | 2019-07-25 | 한국과학기술연구원 | 대사체 및 임상지표를 활용한 관상동맥 심장질환 진단용 키트 및 기초 정보 제공 방법 |
| CN107144648B (zh) * | 2017-04-26 | 2019-11-22 | 苏州海科医药技术有限公司 | 检测人血浆中匹伐他汀的液相色谱-串联质谱方法 |
| CN107014942A (zh) * | 2017-05-05 | 2017-08-04 | 北京骐骥生物技术有限公司 | 利用脂质生物标志物预测糖尿病冠心病的方法 |
| WO2019119049A1 (en) * | 2017-12-20 | 2019-06-27 | Baker Heart and Diabetes Institute | Method of predicting drug therapeutic responder status and methods of treatment |
| WO2020092928A1 (en) * | 2018-11-02 | 2020-05-07 | The Regents Of The University Of California | Compositions and methods for diagnosis of cardiovascular disease |
| WO2020112149A1 (en) * | 2018-12-01 | 2020-06-04 | Binhai Industrial Technology Research Institute Of Zhejiang University | Methods and compositions for the assessment of acute myocardial infarction (ami) |
| CA3122035A1 (en) | 2018-12-06 | 2020-06-11 | Zora Biosciences Oy | Biomarkers for cardiovascular events |
| CN109828076B (zh) * | 2019-04-11 | 2020-07-21 | 江南大学 | 一种高效薄层色谱联用生物发光法筛查贝特类降脂化学药掺伪的方法 |
| CN112630344B (zh) * | 2020-12-08 | 2021-12-14 | 河北医科大学第二医院 | 代谢标志物在脑梗死中的用途 |
| CN113533754A (zh) * | 2021-07-12 | 2021-10-22 | 北京市心肺血管疾病研究所 | 神经酰胺在制备用于评估高血压患者发生不良事件风险的试剂盒中的应用 |
| CN113567583B (zh) * | 2021-07-22 | 2022-06-07 | 江南大学 | 应用固相萃取-超临界流体色谱-质谱法检测乳中极性脂的方法 |
| CN116087487B (zh) * | 2021-11-08 | 2025-06-03 | 中国医学科学院阜外医院 | 糖尿病患者早期预测心血管疾病（cvd）的生物标志物及其用途 |
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| CA2293718A1 (en) * | 1997-06-10 | 1998-12-17 | Medlyte Diagnostics, Inc. | Methods for early detection of heart disease |
| WO2004038381A2 (en) | 2002-10-25 | 2004-05-06 | Metabolon, Inc. | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| US7972802B2 (en) | 2005-10-31 | 2011-07-05 | University Of Washington | Lipoprotein-associated markers for cardiovascular disease |
| US8137977B2 (en) * | 2006-04-24 | 2012-03-20 | Children's Hospital & Research Center At Oakland | Lipidomic approaches to determining drug response phenotypes in cardiovascular disease |
| DE102006034153B4 (de) | 2006-07-24 | 2018-02-08 | Magna powertrain gmbh & co kg | Getriebe |
| US20100179066A1 (en) | 2007-06-07 | 2010-07-15 | Inserm (Institut National De La Santé Et De La Rec | Method for Assessing the Risk of a Cardiovascular Disease and for Diagnosing Dyslipidemia |
| EP2048243A1 (en) * | 2007-09-24 | 2009-04-15 | sanofi-aventis | Use of clec1B for the determination of cardiovascular and thrombotic risk |
| CN101939651A (zh) * | 2007-10-10 | 2011-01-05 | 保函医药公司 | 用于检测严重有害的心血管和脑血管事件的方法 |
| WO2009096903A1 (en) | 2008-01-28 | 2009-08-06 | National University Of Singapore | Lipid tumour profile |
| EP2265642A4 (en) * | 2008-03-12 | 2012-05-02 | Otago Innovation Ltd | BIOMARKERS |
| EP2265641B1 (en) * | 2008-03-12 | 2018-01-24 | Otago Innovation Limited | Biomarkers |
| CA2741117A1 (en) * | 2008-10-30 | 2010-05-06 | Centre De Recherche Public De La Sante | Biomarkers for heart failure |
| US20110034419A1 (en) * | 2009-06-27 | 2011-02-10 | Musc Foundation For Research Development | Cardioprotective Drugs and Diagnostics for Assessing Risk of Cardiovascular Disease |
| JP5739898B2 (ja) * | 2009-11-17 | 2015-06-24 | ベイラー リサーチ インスティテュートＢａｙｌｏｒ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | 心疾患マーカーとしての尿中トリアオシルセラミド（ｇｂ３） |
| AU2010324544A1 (en) | 2009-11-27 | 2012-06-21 | Baker Idi Heart And Diabetes Institute Holdings Limited | Lipid biomarkers for stable and unstable heart disease |
| NO2385374T3 (https=) * | 2010-05-05 | 2014-06-07 | ||
| CN103154742B (zh) * | 2010-06-20 | 2017-11-21 | 佐拉生物科学公司 | 用于鉴定高风险冠状动脉疾病患者的脂质组学标志 |
| EP2400573A1 (de) | 2010-06-23 | 2011-12-28 | Bayer MaterialScience AG | Elektromechanischer Wandler, Verfahren zu dessen Herstellung und Verwendung desselben |
| JP5980900B2 (ja) | 2011-04-08 | 2016-08-31 | ゾラ バイオサイエンシーズ オサケ ユキチュア | スタチン誘発性筋毒性の高感度検出のためのバイオマーカー |
| FI20115576A0 (fi) * | 2011-06-10 | 2011-06-10 | Teknologian Tutkimuskeskus Vtt Oy | Menetelmä Alzheimerin taudin diagnoimiseksi |
| EP2592423A1 (en) | 2011-11-08 | 2013-05-15 | Zora Biosciences OY | Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients not undergoing statin treatment |
-
2011
- 2011-11-08 EP EP11188325.2A patent/EP2592422A1/en not_active Withdrawn
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2012
- 2012-11-07 JP JP2014540427A patent/JP6388284B2/ja active Active
- 2012-11-07 US US14/356,474 patent/US9052327B2/en active Active
- 2012-11-07 CA CA2854422A patent/CA2854422A1/en not_active Abandoned
- 2012-11-07 EP EP12784242.5A patent/EP2776842B1/en active Active
- 2012-11-07 WO PCT/EP2012/071973 patent/WO2013068374A2/en not_active Ceased
- 2012-11-07 HK HK15102546.8A patent/HK1202154A1/xx unknown
- 2012-11-07 CN CN201280054322.3A patent/CN104024860B/zh active Active
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2015
- 2015-05-28 US US14/723,754 patent/US9459265B2/en active Active
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2016
- 2016-08-29 US US15/249,935 patent/US20160363602A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN104024860A (zh) | 2014-09-03 |
| US9052327B2 (en) | 2015-06-09 |
| EP2776842B1 (en) | 2017-07-12 |
| WO2013068374A3 (en) | 2013-07-18 |
| US9459265B2 (en) | 2016-10-04 |
| WO2013068374A2 (en) | 2013-05-16 |
| JP2014532886A (ja) | 2014-12-08 |
| HK1202154A1 (en) | 2015-09-18 |
| US20160363602A1 (en) | 2016-12-15 |
| JP6388284B2 (ja) | 2018-09-12 |
| EP2592422A1 (en) | 2013-05-15 |
| EP2776842A2 (en) | 2014-09-17 |
| US20150260738A1 (en) | 2015-09-17 |
| CN104024860B (zh) | 2017-06-06 |
| US20140295466A1 (en) | 2014-10-02 |
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