CA2853910A1 - Isolating and therapeutic use of perivascular medicinal cells - Google Patents

Isolating and therapeutic use of perivascular medicinal cells Download PDF

Info

Publication number
CA2853910A1
CA2853910A1 CA2853910A CA2853910A CA2853910A1 CA 2853910 A1 CA2853910 A1 CA 2853910A1 CA 2853910 A CA2853910 A CA 2853910A CA 2853910 A CA2853910 A CA 2853910A CA 2853910 A1 CA2853910 A1 CA 2853910A1
Authority
CA
Canada
Prior art keywords
bone
pvmcs
blood vessel
umbilical cord
cord blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2853910A
Other languages
English (en)
French (fr)
Inventor
Arnold I. Caplan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Safeguard Cell Technology Inc
Original Assignee
Safeguard Cell Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Safeguard Cell Technology Inc filed Critical Safeguard Cell Technology Inc
Publication of CA2853910A1 publication Critical patent/CA2853910A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0605Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B02CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02CCRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00Other disintegrating devices or methods
    • B02C19/0056Other disintegrating devices or methods specially adapted for specific materials not otherwise provided for
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0668Mesenchymal stem cells from other natural sources
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00Methods for the dissociation of cells, e.g. specific use of enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
CA2853910A 2011-08-29 2012-08-27 Isolating and therapeutic use of perivascular medicinal cells Abandoned CA2853910A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161528556P 2011-08-29 2011-08-29
US201161528563P 2011-08-29 2011-08-29
US201161528567P 2011-08-29 2011-08-29
US61/528,556 2011-08-29
US61/528,563 2011-08-29
US61/528,567 2011-08-29
PCT/US2012/052575 WO2013033043A1 (en) 2011-08-29 2012-08-27 Isolating and therapeutic use of perivascular medicinal cells

Publications (1)

Publication Number Publication Date
CA2853910A1 true CA2853910A1 (en) 2013-03-07

Family

ID=47756794

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2853910A Abandoned CA2853910A1 (en) 2011-08-29 2012-08-27 Isolating and therapeutic use of perivascular medicinal cells

Country Status (7)

Country Link
US (1) US20140314869A1 (enExample)
EP (1) EP2751256A4 (enExample)
JP (1) JP2014529406A (enExample)
AU (1) AU2012300221A1 (enExample)
CA (1) CA2853910A1 (enExample)
SG (1) SG11201401038VA (enExample)
WO (1) WO2013033043A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105505862A (zh) * 2015-12-29 2016-04-20 江苏省原子医学研究所 一种采用机械分离法提取骨组织中的成骨细胞的方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10758573B2 (en) 2015-06-09 2020-09-01 President And Fellows Of Harvard College Compositions and methods for enrichment of cells
AU2018283372B2 (en) 2017-06-16 2024-06-13 Avery Therapeutics, Inc. Three dimensional tissue compositions and methods of use
CN111601606A (zh) 2017-11-29 2020-08-28 菲格内有限责任公司 用于活化的成纤维细胞与免疫细胞的相互作用及其用途
WO2020092321A1 (en) * 2018-10-29 2020-05-07 Avery Therapeutics, Inc. Compositions and methods for cryopreservation and reconstitution of engineered tissues
EP3921029B1 (en) * 2019-02-07 2025-07-30 Baylor College of Medicine Composition comprising ccl5 for use in treating bone break, bone fracture, bone degeneration and osteoporosis
CN115772494B (zh) * 2021-09-06 2025-10-21 上海交通大学医学院附属第九人民医院 一种牙槽骨组织消化液及其在牙槽骨细胞分离中的用途和方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
AU2003901668A0 (en) * 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
US20030095993A1 (en) * 2000-01-28 2003-05-22 Hanne Bentz Gel-infused sponges for tissue repair and augmentation
GB0600972D0 (en) * 2006-01-18 2006-03-01 Univ Leeds Enrichment of cells
US20070264239A1 (en) * 2006-05-10 2007-11-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Isolation of pericytes
EP2288359B1 (en) * 2008-04-21 2019-10-02 Tissue Regeneration Therapeutics Inc. Genetically modified human umbilical cord perivascular cells for prophylaxis against or treatment of biological or chemical agents
US8470308B2 (en) * 2009-01-03 2013-06-25 Ray C. Wasielewski Enhanced medical implant comprising disrupted tooth pulp and tooth particles
US20120148546A1 (en) * 2009-08-17 2012-06-14 Technion Research & Development Foundation Ltd. Pericyte progenitor cells and methods of generating and using same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105505862A (zh) * 2015-12-29 2016-04-20 江苏省原子医学研究所 一种采用机械分离法提取骨组织中的成骨细胞的方法
CN105505862B (zh) * 2015-12-29 2019-01-18 江苏省原子医学研究所 一种采用机械分离法提取骨组织中的成骨细胞的方法

Also Published As

Publication number Publication date
WO2013033043A1 (en) 2013-03-07
AU2012300221A1 (en) 2014-04-17
US20140314869A1 (en) 2014-10-23
EP2751256A1 (en) 2014-07-09
EP2751256A4 (en) 2015-01-28
JP2014529406A (ja) 2014-11-13
SG11201401038VA (en) 2014-07-30

Similar Documents

Publication Publication Date Title
EP2292736B1 (en) Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue
de Girolamo et al. Mesenchymal stem/stromal cells: a new''cells as drugs''paradigm. Efficacy and critical aspects in cell therapy
CN103340904B (zh) 治疗骨关节炎的组合物
US20100172885A1 (en) Multipotent Adult Stem Cells And Uses of Multipotent Adult Stem Cells To Treat Inflammation
US20140314869A1 (en) Isolating and therapeutic use of perivascular medicinal cells
CA2556018A1 (en) Stem cell populations and methods of use
Cox et al. High abundance of CD271+ multipotential stromal cells (MSCs) in intramedullary cavities of long bones
WO2014015229A1 (en) Isolation of stromal vascular fraction from adipose tissue obtained from postmortem source using ultrasonic cavitation
US11578306B2 (en) Methods for propagating mesenchymal stem cells (MSC) for use in transplantation
CN113750220B (zh) 间充质干细胞联合tpo及其类似物在治疗慢性髓性白血病中的应用
Leonardi et al. Isolation, characterisation and osteogenic potential of human bone marrow stromal cells derived from the medullary cavity of the femur
Kouroupis et al. The safety of non-expanded multipotential stromal cell therapies
KR102121602B1 (ko) 지방줄기세포배양용 배지 조성물 제조방법, 지방줄기세포배양용 배지 조성물 제조방법과 줄기세포 유효성분 3저 추출법을 이용한 줄기세포파쇄추출물(쉘드줄기세포) 제조방법, 이를 이용한 항관절염 치료용 조성물, 이를 이용한 염증억제 효과를 갖는 조성물 및 세포재생 효과를 갖는 조성물
CN111172106A (zh) 一种从人胎盘或脐带中提取间充质干细胞及提取其分泌物的方法
Phedy et al. Iliac crest and femoral bone marrow as the source of plastic-adherent cells
Mandour et al. Basic Sciences Behind BMAC and Expanded Stem Cells
AU2011253985B2 (en) Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue
AU2023204145A1 (en) Mesenchymal stem cells and uses therefor
Murphy et al. V. Mesenchymal Stem Cells in Regenerative Medicine
HK1236998A1 (en) Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20170810

FZDE Discontinued

Effective date: 20211013