CA2850335A1 - Dispositifs et procedes pour separation de particules basee sur forme - Google Patents

Dispositifs et procedes pour separation de particules basee sur forme Download PDF

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Publication number
CA2850335A1
CA2850335A1 CA 2850335 CA2850335A CA2850335A1 CA 2850335 A1 CA2850335 A1 CA 2850335A1 CA 2850335 CA2850335 CA 2850335 CA 2850335 A CA2850335 A CA 2850335A CA 2850335 A1 CA2850335 A1 CA 2850335A1
Authority
CA
Canada
Prior art keywords
particles
outlets
fluidic
particle
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2850335
Other languages
English (en)
Inventor
Dino Di Carlo
Mahdokht MASAELI
Elodie Sollier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of CA2850335A1 publication Critical patent/CA2850335A1/fr
Abandoned legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03BSEPARATING SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS
    • B03B5/00Washing granular, powdered or lumpy materials; Wet separating
    • B03B5/48Washing granular, powdered or lumpy materials; Wet separating by mechanical classifiers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • G01N1/4077Concentrating samples by other techniques involving separation of suspended solids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0636Focussing flows, e.g. to laminate flows
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652Sorting or classification of particles or molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088Channel loops
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N2015/0288Sorting the particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N2015/0294Particle shape

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Fluid Mechanics (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA 2850335 2011-09-30 2012-09-27 Dispositifs et procedes pour separation de particules basee sur forme Abandoned CA2850335A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161541934P 2011-09-30 2011-09-30
US61/541,934 2011-09-30
US201261606287P 2012-03-02 2012-03-02
US61/606,287 2012-03-02
PCT/US2012/057631 WO2013089883A2 (fr) 2011-09-30 2012-09-27 Dispositifs et procédés pour séparation de particules basée sur forme

Publications (1)

Publication Number Publication Date
CA2850335A1 true CA2850335A1 (fr) 2013-06-20

Family

ID=48613336

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2850335 Abandoned CA2850335A1 (fr) 2011-09-30 2012-09-27 Dispositifs et procedes pour separation de particules basee sur forme

Country Status (9)

Country Link
US (1) US9333510B2 (fr)
EP (1) EP2761303B1 (fr)
JP (1) JP6031109B2 (fr)
KR (1) KR20140084075A (fr)
CN (1) CN103959069B (fr)
AU (1) AU2012352879B2 (fr)
CA (1) CA2850335A1 (fr)
ES (1) ES2626848T3 (fr)
WO (1) WO2013089883A2 (fr)

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US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
EP4137798A1 (fr) 2015-02-19 2023-02-22 1087 Systems, Inc. Système de mesure infrarouge à balayage
US10591403B2 (en) 2016-03-16 2020-03-17 Georgia Tech Research Corporation Multiplexed analysis of cell-materials in niches
US10471425B2 (en) 2017-02-16 2019-11-12 International Business Machines Corporation Automated machine for sorting of biological fluids
US10921224B2 (en) * 2017-11-14 2021-02-16 Aerodyne Microsystems Inc. Thermophoretic particle detection system with variable channel geometry
CN108405169B (zh) * 2018-03-07 2020-03-10 中国工程物理研究院激光聚变研究中心 一种液体筛分微球装置
US11229912B2 (en) 2018-03-27 2022-01-25 Hewlett-Packard Development Company, L.P. Particle separation
JP7320003B2 (ja) * 2018-05-09 2023-08-02 エフ. ホフマン-ラ ロシュ アーゲー 試料中の粒子濃度を決定するための装置および方法
US11331670B2 (en) 2018-05-23 2022-05-17 Abs Global, Inc. Systems and methods for particle focusing in microchannels
CN108872047B (zh) * 2018-08-15 2021-02-26 军事科学院系统工程研究院卫勤保障技术研究所 一种微流控电阻抗检测区分微小粒子形状的系统及方法
US11815507B2 (en) 2018-08-15 2023-11-14 Deepcell, Inc. Systems and methods for particle analysis
US10611995B2 (en) * 2018-08-15 2020-04-07 Deepcell, Inc. Systems and methods for particle analysis
US11524292B2 (en) * 2019-02-21 2022-12-13 International Business Machines Corporation Programmable hydraulic resistor array for microfluidic chips
EP4245140A3 (fr) 2019-04-18 2024-01-17 ABS Global, Inc. Système et procédé d'ajout en continu de cryoprotecteur
US12053569B2 (en) 2019-09-04 2024-08-06 The Regents Of The University Of Michigan Indwelling intravascular aphaeretic system for in vivo enrichment of circulating tumor cells
WO2021080506A1 (fr) * 2019-10-21 2021-04-29 Nanyang Technological University Isolement direct et évolutif de vésicules extracellulaires circulantes à partir de sang total à l'aide de forces centrifuges
US11628439B2 (en) * 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip
US20240094106A1 (en) * 2021-02-03 2024-03-21 University Of Georgia Research Foundation, Inc. Devices, kits, and methods for label-free inertial ferrohydrodynamic cell separation with high throughput and resolution
CN112973815B (zh) * 2021-03-09 2022-06-03 西北大学 一种聚集非球形微游泳体的微流管道及一种过滤方法
CN113769797B (zh) * 2021-09-02 2023-03-14 浙江理工大学 一种流固两相输运中的微尺度颗粒直径测定的方法
CN118067593A (zh) * 2022-11-22 2024-05-24 中国科学院深圳先进技术研究院 微流控分选芯片、控制设备、微流控分选系统及方法

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
WO2008016414A2 (fr) * 2006-06-01 2008-02-07 The Trustees Of Princeton University Appareil et procédé pour une séparation continue de particules
EP2562531A3 (fr) * 2007-04-16 2013-03-06 The General Hospital Corporation d/b/a Massachusetts General Hospital Systèmes et procédés de mise au point de particules dans des micro-canaux
JP5304506B2 (ja) * 2009-07-22 2013-10-02 富士ゼロックス株式会社 分級装置及び分級方法
KR20130000396A (ko) * 2010-03-04 2013-01-02 메사추세츠 인스티튜트 오브 테크놀로지 세포 검출 및 단리를 위한 마이크로유체 선별기
US8590710B2 (en) * 2010-06-10 2013-11-26 Samsung Electronics Co., Ltd. Target particles-separating device and method using multi-orifice flow fractionation channel
US9090865B2 (en) * 2010-10-29 2015-07-28 The Regents Of The University Of California Systems and methods for particle classification and sorting

Also Published As

Publication number Publication date
AU2012352879A1 (en) 2014-04-10
WO2013089883A3 (fr) 2013-08-29
EP2761303B1 (fr) 2017-03-01
AU2012352879B2 (en) 2017-01-05
KR20140084075A (ko) 2014-07-04
EP2761303A4 (fr) 2015-06-03
JP6031109B2 (ja) 2016-11-24
EP2761303A2 (fr) 2014-08-06
ES2626848T3 (es) 2017-07-26
CN103959069B (zh) 2016-02-24
US20140224710A1 (en) 2014-08-14
US9333510B2 (en) 2016-05-10
CN103959069A (zh) 2014-07-30
JP2015501136A (ja) 2015-01-15
WO2013089883A2 (fr) 2013-06-20

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20180927