CA2849072A1 - Compositions and methods relating to nucleic acid nano-and micro-technology - Google Patents

Compositions and methods relating to nucleic acid nano-and micro-technology Download PDF

Info

Publication number
CA2849072A1
CA2849072A1 CA2849072A CA2849072A CA2849072A1 CA 2849072 A1 CA2849072 A1 CA 2849072A1 CA 2849072 A CA2849072 A CA 2849072A CA 2849072 A CA2849072 A CA 2849072A CA 2849072 A1 CA2849072 A1 CA 2849072A1
Authority
CA
Canada
Prior art keywords
oligonucleotides
nucleic acid
domains
structures
acid structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2849072A
Other languages
English (en)
French (fr)
Inventor
Peng Yin
Diming WEI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of CA2849072A1 publication Critical patent/CA2849072A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2849072A 2011-08-05 2012-08-02 Compositions and methods relating to nucleic acid nano-and micro-technology Pending CA2849072A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161515435P 2011-08-05 2011-08-05
US61/515,435 2011-08-05
US201261612018P 2012-03-16 2012-03-16
US61/612,018 2012-03-16
PCT/US2012/049306 WO2013022694A1 (en) 2011-08-05 2012-08-02 Compositions and methods relating to nucleic acid nano-and micro-technology

Publications (1)

Publication Number Publication Date
CA2849072A1 true CA2849072A1 (en) 2013-02-14

Family

ID=47668817

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2849072A Pending CA2849072A1 (en) 2011-08-05 2012-08-02 Compositions and methods relating to nucleic acid nano-and micro-technology

Country Status (9)

Country Link
US (1) US9796749B2 (cg-RX-API-DMAC10.html)
EP (1) EP2739638B1 (cg-RX-API-DMAC10.html)
JP (1) JP2014525921A (cg-RX-API-DMAC10.html)
KR (1) KR20140054179A (cg-RX-API-DMAC10.html)
CN (2) CN103889998A (cg-RX-API-DMAC10.html)
AU (1) AU2012294724B2 (cg-RX-API-DMAC10.html)
CA (1) CA2849072A1 (cg-RX-API-DMAC10.html)
SG (1) SG10201606482TA (cg-RX-API-DMAC10.html)
WO (1) WO2013022694A1 (cg-RX-API-DMAC10.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103328654B (zh) 2010-10-27 2017-07-11 哈佛学院院长等 立足点引物双链体的组合物及其使用方法
US9796748B2 (en) 2011-05-02 2017-10-24 President And Fellows Of Harvard College Spatial sequestration of dynamic nucleic acid circuits
CN103889998A (zh) 2011-08-05 2014-06-25 哈佛学院院长等 涉及核酸纳米和微米技术的组合物和方法
WO2014012071A1 (en) 2012-07-12 2014-01-16 Massachusetts Institute Of Technology Methods and apparatus for assembly
US10604543B2 (en) 2012-07-24 2020-03-31 President And Fellows Of Harvard College Self-assembly of nucleic acid nanostructures
WO2014074597A1 (en) 2012-11-06 2014-05-15 President And Fellows Of Harvard College Compositions and methods relating to complex nucleic acid nanostructures
CN106661616A (zh) 2014-04-23 2017-05-10 儿童医学中心公司 使用核酸卡尺的高通量结构测定
TWI621584B (zh) 2014-05-22 2018-04-21 President And Fellows Of Harvard College 可縮放核酸奈米製造技術
ES2891085T3 (es) 2015-01-30 2022-01-26 Harvard College Obtención de imágenes sin microscopio
WO2016144755A1 (en) 2015-03-07 2016-09-15 President And Fellows Of Harvard College Single-stranded dna nanostructures
CN105602949A (zh) * 2016-01-29 2016-05-25 同济大学 链间交换由支架dna达成的核酸结构及其合成方法
CA3017945A1 (en) 2016-04-26 2017-11-02 Ultivue, Inc. Super-resolution immunofluorescence with diffraction-limited preview
WO2017216270A1 (de) 2016-06-15 2017-12-21 Grabmayr Heinrich Einzelmolekülnachweis bzw. -quantifizierung durch dna-nanotechnologie
CN106517087B (zh) * 2017-01-06 2018-09-28 中国科学院苏州纳米技术与纳米仿生研究所 纳米颗粒螺旋和纳米棒组合结构及其构建方法
WO2018213372A1 (en) 2017-05-16 2018-11-22 President And Fellows Of Harvard College Nucleic acid-lined nanodiscs
WO2018218646A1 (zh) * 2017-06-02 2018-12-06 清华大学 Dna折纸单元分步组装法
EP3696275B1 (en) * 2017-10-11 2025-12-24 MGI Tech Co., Ltd. Method for improving loading and stability of nucleic acid on solid support
US12142104B2 (en) 2018-03-22 2024-11-12 President And Fellows Of Harvard College Methods and compositions for molecular authentication
CN112236528A (zh) 2018-04-04 2021-01-15 诺迪勒思生物科技公司 产生纳米阵列和微阵列的方法
US12270030B2 (en) 2018-06-05 2025-04-08 Technische Universität München Method for stabilizing nucleic acid nanostructures
AU2020266136B2 (en) 2019-04-29 2026-04-02 Nautilus Subsidiary, Inc. Methods and systems for integrated on-chip single-molecule detection
US10777381B1 (en) * 2019-08-08 2020-09-15 Ut-Battelle, Llc Beam controlled nano-robotic device
WO2021222635A2 (en) * 2020-04-30 2021-11-04 Mpeg La, L.L.C. Multimeric oligonucleotides with divided strands
EP4244382A1 (en) 2020-11-11 2023-09-20 Nautilus Subsidiary, Inc. Affinity reagents having enhanced binding and detection characteristics
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
EP4399528A1 (en) 2021-09-09 2024-07-17 Nautilus Subsidiary, Inc. Characterization and localization of protein modifications
EP4441503A1 (en) 2021-11-30 2024-10-09 Nautilus Subsidiary, Inc. Particle-based isolation of proteins and other analytes
EP4764494A1 (en) * 2024-12-20 2026-06-24 Plectonic Biotech GmbH Conjugates for analyte detection and quantification

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6444650B1 (en) 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
US6031098A (en) 1997-08-11 2000-02-29 California Institute Of Technology Detection and treatment of duplex polynucleotide damage
US6255469B1 (en) 1998-05-06 2001-07-03 New York University Periodic two and three dimensional nucleic acid structures
KR20020059727A (ko) 1999-11-13 2002-07-13 플레믹 크리스티안 고차 핵산 기재 구조
JP4340779B2 (ja) 2000-10-05 2009-10-07 独立行政法人理化学研究所 可変突出部位を含むオリゴヌクレオチドリンカー及び前記リンカーを用いたポリヌクレオチドライブラリーの調製方法
US7612184B2 (en) * 2002-02-22 2009-11-03 New York University Polynucleic acid nanomechanical device controlled by hybridization topology
JP4061401B2 (ja) * 2002-03-07 2008-03-19 国立大学法人九州大学 Dnaの自己組織化によるdnaナノケージ及びその製造方法、並びにそれを用いたdnaナノチューブ、分子キャリアー
JPWO2005024018A1 (ja) 2003-09-08 2007-11-08 株式会社モレキュエンス 核酸構築物およびその製造方法
WO2006085921A2 (en) * 2004-06-10 2006-08-17 New York University Polygonal nanostructures of polynucleic acid multi-crossover molecules and assembly of lattices based on double crossover cohesion
WO2006017432A2 (en) 2004-08-02 2006-02-16 New York University A polynucleotide nanomechanical device that acts as an artificial ribosome and translates dna signals into polymer assembly instructions
US7842793B2 (en) 2005-06-14 2010-11-30 The California Institute Of Technology Methods of making nucleic acid nanostructures
US7745594B2 (en) 2005-07-21 2010-06-29 California Institute Of Technology Nucleic acid-based logic circuits
WO2007012807A2 (en) 2005-07-27 2007-02-01 University Of Leeds Dna structures
WO2007103558A2 (en) 2006-03-09 2007-09-13 The Regents Of The University Of California Hybrid energy transfer for nucleic acid detection
CN101541961A (zh) * 2006-10-04 2009-09-23 布鲁克哈文科学协会 Dna指导的纳米颗粒组装体
US20080221315A1 (en) 2006-12-07 2008-09-11 New York University Nucleic acid-based translation system and method for decoding nucleic acid encrypted message
US20100216978A1 (en) 2007-04-17 2010-08-26 Dsna-Farber Cancer Institute Inc. Wireframe nanostructures
WO2009093558A1 (ja) * 2008-01-22 2009-07-30 Tokyo Institute Of Technology 核酸構造体及びその核酸構造体を用いた核酸構造物、並びにその核酸構造物の作製方法
US20100291485A1 (en) 2008-09-14 2010-11-18 Troy Lapsys Nanoscale molecule synthesis
US9732337B2 (en) * 2009-06-16 2017-08-15 The United Stated of America, as represented by the Secretary, Department of Health & Human Services RNA nanoparticles and nanotubes
US20130065777A1 (en) 2009-12-04 2013-03-14 Trustees Of Boston University Nanostructure biosensors and systems and methods of use thereof
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
WO2012058638A2 (en) 2010-10-29 2012-05-03 President And Fellows Of Harvard College Nucleic acid nanostructure barcode probes
US20130316358A1 (en) 2011-01-31 2013-11-28 Yeda Research And Development Co. Ltd. Methods of diagnosing disease using overlap extension pcr
GB201111237D0 (en) 2011-06-30 2011-08-17 Isis Innovation Nanochip
CN103889998A (zh) 2011-08-05 2014-06-25 哈佛学院院长等 涉及核酸纳米和微米技术的组合物和方法
US10604543B2 (en) 2012-07-24 2020-03-31 President And Fellows Of Harvard College Self-assembly of nucleic acid nanostructures
WO2014074597A1 (en) 2012-11-06 2014-05-15 President And Fellows Of Harvard College Compositions and methods relating to complex nucleic acid nanostructures
US20170015698A1 (en) 2014-03-08 2017-01-19 President And Fellows Of Harvard College Nucleic acid polyhedra from self-assembled vertex-containing fixed-angle nucleic acid structures

Also Published As

Publication number Publication date
JP2014525921A (ja) 2014-10-02
CN107698640A (zh) 2018-02-16
KR20140054179A (ko) 2014-05-08
EP2739638B1 (en) 2017-10-04
AU2012294724B2 (en) 2017-05-04
WO2013022694A1 (en) 2013-02-14
EP2739638A1 (en) 2014-06-11
US9796749B2 (en) 2017-10-24
EP2739638A4 (en) 2015-04-08
US20140213778A1 (en) 2014-07-31
AU2012294724A1 (en) 2014-03-06
SG10201606482TA (en) 2016-10-28
CN103889998A (zh) 2014-06-25

Similar Documents

Publication Publication Date Title
US9796749B2 (en) Compositions and methods relating to nucleic acid nano- and micro-technology
US9975916B2 (en) Compositions and methods relating to complex nucleic acid nanostructures
EP2877600B1 (en) Self-assembly of nucleic acid nanostructures
US20030045698A1 (en) Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
US20120022244A1 (en) Self-assembled polynucleotide structure
WO2000027859A1 (en) Improved processes for the synthesis of oligomeric compounds
EP3145859A2 (en) Scalable nucleic acid-based nanofabrication
CA2494571C (en) Oligonucleotides containing molecular rods
JP2004501211A5 (cg-RX-API-DMAC10.html)
CN113474633A (zh) 寡核苷酸配制方法
US6312953B1 (en) Bifunctional Crosslinking oligonucleotides adapted for linking to a target sequence of duplex DNA
WO2017049136A1 (en) Nucleic acid frameworks for structural determination
HK1198038A (en) Compositions and methods relating to nucleic acid nano-and micro-technology
EP2630255B1 (en) A conjugate between a thiophilic solid phase and an oligonucleotide comprising a thiooxonucleotide
EP4419710B1 (en) Pre-library target enrichment for nucleic acid sequencing
Ondruš Approaches to the enzymatic synthesis of hypermodified DNA polymers
Zilbershtein-Shklanovsky et al. Development of fluorescent double-strand probes labeled with 8-(p-CF3-cinnamyl)-adenosine for the detection of cyclin D1 breast cancer marker
Keller Generation and regulation of enzyme-catalyzed DNA network growth using branched DNA motives
HK1210628B (en) Self-assembly of nucleic acid nanostructures
HK40060206A (en) Oligonucleotide formulation method
Fillon et al. 3 Oligonucleotide Synthesis
Liu Construction of circular oligodeoxyribonucleotides on the structural basis of i-motif
CN103502452A (zh) 堆积核酸及其使用方法