CA2841169C - Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse - Google Patents

Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse Download PDF

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Publication number
CA2841169C
CA2841169C CA2841169A CA2841169A CA2841169C CA 2841169 C CA2841169 C CA 2841169C CA 2841169 A CA2841169 A CA 2841169A CA 2841169 A CA2841169 A CA 2841169A CA 2841169 C CA2841169 C CA 2841169C
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CA
Canada
Prior art keywords
alpha
cyclopropylmethyl
methoxy
epoxy
dihydro
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CA2841169A
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English (en)
French (fr)
Other versions
CA2841169A1 (en
Inventor
John Lewis
Stephen Husbands
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Bath
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University of Bath
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2841169A 2011-07-08 2012-07-05 Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse Active CA2841169C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1111775.1 2011-07-08
GBGB1111775.1A GB201111775D0 (en) 2011-07-08 2011-07-08 Compounds and uses thereof
PCT/GB2012/051575 WO2013007986A1 (en) 2011-07-08 2012-07-05 Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse

Publications (2)

Publication Number Publication Date
CA2841169A1 CA2841169A1 (en) 2013-01-17
CA2841169C true CA2841169C (en) 2019-08-27

Family

ID=44544490

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2841169A Active CA2841169C (en) 2011-07-08 2012-07-05 Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse

Country Status (15)

Country Link
US (5) US9051334B2 (https=)
EP (1) EP2729469B1 (https=)
JP (2) JP6117780B2 (https=)
CA (1) CA2841169C (https=)
CY (1) CY1117674T1 (https=)
DK (1) DK2729469T3 (https=)
ES (1) ES2572508T3 (https=)
GB (1) GB201111775D0 (https=)
HR (1) HRP20160389T1 (https=)
HU (1) HUE028785T2 (https=)
PL (1) PL2729469T3 (https=)
RS (1) RS54830B1 (https=)
SI (1) SI2729469T1 (https=)
SM (1) SMT201600154B (https=)
WO (1) WO2013007986A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201111775D0 (en) * 2011-07-08 2011-08-24 Univ Bath Compounds and uses thereof
EP2763996B1 (en) 2011-10-03 2018-07-25 Johnson Matthey PLC Process for preparing buprenorphine
EP3087078B1 (en) 2013-12-26 2019-05-15 Purdue Pharma LP 7-beta-alkyl analogs of orvinols
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
GB201716830D0 (en) * 2017-10-13 2017-11-29 Cambrex Charles City Inc New Process
CN110117288A (zh) * 2018-02-07 2019-08-13 复旦大学 7β-甲基-奈培酮衍生物及其制备方法和用途
CN114195798B (zh) * 2021-12-31 2023-07-28 复旦大学 7α-甲基稠环吗啡类衍生物及其制备方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB1136214A (en) 1965-06-15 1968-12-11 Reckitt & Sons Ltd Thebaine and oripavine derivatives
GB925723A (en) 1960-09-05 1963-05-08 J F Macfarlan & Company Ltd Novel thebaine derivatives
GB937214A (en) 1961-06-02 1963-09-18 J F Macfarlan & Company Ltd Oripavine derivatives
GB902659A (en) 1961-02-02 1962-08-09 J F Macfarlan & Company Ltd A process for the production of a derivative of thebaine
NL289751A (https=) 1962-03-02
DE1493696A1 (de) 1965-02-17 1969-12-18 Hoechst Ag Verfahren zur Herstellung klarfluessiger,leicht mit Wasser verduennbarer Fettsaeurekondensationsprodukte
WO2004078178A1 (en) 2003-03-03 2004-09-16 Markus Heilig Buprenorphine compounds for treatment of alcohol dependence and excessive alcohol use
GB201111775D0 (en) * 2011-07-08 2011-08-24 Univ Bath Compounds and uses thereof
JP6314571B2 (ja) * 2013-12-16 2018-04-25 ヤマハ株式会社 反力発生装置

Also Published As

Publication number Publication date
US10030031B2 (en) 2018-07-24
SMT201600154B (it) 2016-08-31
US20180030062A1 (en) 2018-02-01
US9480684B2 (en) 2016-11-01
JP2014522854A (ja) 2014-09-08
JP2015172089A (ja) 2015-10-01
RS54830B1 (sr) 2016-10-31
US20170044173A1 (en) 2017-02-16
US20150202200A1 (en) 2015-07-23
CY1117674T1 (el) 2017-05-17
WO2013007986A1 (en) 2013-01-17
PL2729469T3 (pl) 2016-09-30
JP6117780B2 (ja) 2017-04-19
HRP20160389T1 (hr) 2016-07-01
DK2729469T3 (en) 2016-07-18
US20160136151A1 (en) 2016-05-19
GB201111775D0 (en) 2011-08-24
HUE028785T2 (en) 2017-01-30
EP2729469B1 (en) 2016-03-30
SI2729469T1 (sl) 2016-07-29
US9890170B2 (en) 2018-02-13
US20140213603A1 (en) 2014-07-31
US9259422B2 (en) 2016-02-16
JP6117862B2 (ja) 2017-04-19
ES2572508T3 (es) 2016-05-31
US9051334B2 (en) 2015-06-09
CA2841169A1 (en) 2013-01-17
HK1198031A1 (zh) 2015-03-06
EP2729469A1 (en) 2014-05-14

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