CA2836827C - Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases - Google Patents

Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases Download PDF

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Publication number
CA2836827C
CA2836827C CA2836827A CA2836827A CA2836827C CA 2836827 C CA2836827 C CA 2836827C CA 2836827 A CA2836827 A CA 2836827A CA 2836827 A CA2836827 A CA 2836827A CA 2836827 C CA2836827 C CA 2836827C
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Canada
Prior art keywords
amino acid
inhibitor
ester
conjugate
acid ester
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Active
Application number
CA2836827A
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English (en)
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CA2836827A1 (fr
Inventor
Alan Hornsby Davidson
Alan Hastings Drummond
Lindsey Ann Needham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Macrophage Pharma Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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Priority claimed from CA2607020A external-priority patent/CA2607020C/fr
Publication of CA2836827A1 publication Critical patent/CA2836827A1/fr
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Publication of CA2836827C publication Critical patent/CA2836827C/fr
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La conjugaison covalente dun ester aminé alpha à un modulateur de l'activité dune enzyme intracellulaire cible ou dun récepteur, où le groupe ester du conjugué est hydrolysable par une ou plusieurs enzymes carboxylestérases intracellulaires à lacide correspondant, mène à laccumulation du produit dhydrolyse d'acide carboxylique dans la cellule et permet une modulation améliorée ou prolongée de lenzyme ou du récepteur par rapport au modulateur non conjugué.
CA2836827A 2005-05-05 2006-05-04 Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases Active CA2836827C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0509226.7 2005-05-05
GB0509226A GB0509226D0 (en) 2005-05-05 2005-05-05 Enzyme and receptor modulation
US68054205P 2005-05-13 2005-05-13
US60/680,542 2005-05-13
CA2607020A CA2607020C (fr) 2005-05-05 2006-05-04 Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2607020A Division CA2607020C (fr) 2005-05-05 2006-05-04 Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases

Publications (2)

Publication Number Publication Date
CA2836827A1 CA2836827A1 (fr) 2006-11-09
CA2836827C true CA2836827C (fr) 2016-05-03

Family

ID=34685158

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2836827A Active CA2836827C (fr) 2005-05-05 2006-05-04 Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases

Country Status (10)

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CN (1) CN101171039B (fr)
CA (1) CA2836827C (fr)
DK (1) DK1877098T3 (fr)
ES (2) ES2577433T3 (fr)
GB (1) GB0509226D0 (fr)
NZ (1) NZ561710A (fr)
PT (1) PT1877098E (fr)
SG (1) SG2014007512A (fr)
SI (1) SI1877098T1 (fr)
ZA (1) ZA200708283B (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1378450A (zh) * 1999-09-08 2002-11-06 斯隆-凯特林癌症研究院 新型细胞分化剂和组蛋白脱乙酰基酶抑制剂及其使用方法
WO2005037272A1 (fr) * 2003-10-22 2005-04-28 Arpida A/S Derives de benzimidazole et leur application comme inhibiteurs de la peptide-deformylase

Also Published As

Publication number Publication date
SI1877098T1 (sl) 2013-08-30
NZ561710A (en) 2010-08-27
PT1877098E (pt) 2013-07-31
CA2836827A1 (fr) 2006-11-09
ZA200708283B (en) 2008-10-29
DK1877098T3 (da) 2013-07-08
GB0509226D0 (en) 2005-06-15
CN101171039B (zh) 2013-01-23
ES2415244T3 (es) 2013-07-24
SG2014007512A (en) 2014-03-28
CN101171039A (zh) 2008-04-30
ES2577433T3 (es) 2016-07-14

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Effective date: 20131217