CA2836827C - Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases - Google Patents
Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases Download PDFInfo
- Publication number
- CA2836827C CA2836827C CA2836827A CA2836827A CA2836827C CA 2836827 C CA2836827 C CA 2836827C CA 2836827 A CA2836827 A CA 2836827A CA 2836827 A CA2836827 A CA 2836827A CA 2836827 C CA2836827 C CA 2836827C
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- inhibitor
- ester
- conjugate
- acid ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
La conjugaison covalente dun ester aminé alpha à un modulateur de l'activité dune enzyme intracellulaire cible ou dun récepteur, où le groupe ester du conjugué est hydrolysable par une ou plusieurs enzymes carboxylestérases intracellulaires à lacide correspondant, mène à laccumulation du produit dhydrolyse d'acide carboxylique dans la cellule et permet une modulation améliorée ou prolongée de lenzyme ou du récepteur par rapport au modulateur non conjugué.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0509226.7 | 2005-05-05 | ||
GB0509226A GB0509226D0 (en) | 2005-05-05 | 2005-05-05 | Enzyme and receptor modulation |
US68054205P | 2005-05-13 | 2005-05-13 | |
US60/680,542 | 2005-05-13 | ||
CA2607020A CA2607020C (fr) | 2005-05-05 | 2006-05-04 | Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2607020A Division CA2607020C (fr) | 2005-05-05 | 2006-05-04 | Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2836827A1 CA2836827A1 (fr) | 2006-11-09 |
CA2836827C true CA2836827C (fr) | 2016-05-03 |
Family
ID=34685158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2836827A Active CA2836827C (fr) | 2005-05-05 | 2006-05-04 | Conjugues d'ester amine alpha hydrolysables par des coarboxylesterases |
Country Status (10)
Country | Link |
---|---|
CN (1) | CN101171039B (fr) |
CA (1) | CA2836827C (fr) |
DK (1) | DK1877098T3 (fr) |
ES (2) | ES2577433T3 (fr) |
GB (1) | GB0509226D0 (fr) |
NZ (1) | NZ561710A (fr) |
PT (1) | PT1877098E (fr) |
SG (1) | SG2014007512A (fr) |
SI (1) | SI1877098T1 (fr) |
ZA (1) | ZA200708283B (fr) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1378450A (zh) * | 1999-09-08 | 2002-11-06 | 斯隆-凯特林癌症研究院 | 新型细胞分化剂和组蛋白脱乙酰基酶抑制剂及其使用方法 |
WO2005037272A1 (fr) * | 2003-10-22 | 2005-04-28 | Arpida A/S | Derives de benzimidazole et leur application comme inhibiteurs de la peptide-deformylase |
-
2005
- 2005-05-05 GB GB0509226A patent/GB0509226D0/en not_active Ceased
-
2006
- 2006-05-04 PT PT06727008T patent/PT1877098E/pt unknown
- 2006-05-04 DK DK06727008.2T patent/DK1877098T3/da active
- 2006-05-04 CA CA2836827A patent/CA2836827C/fr active Active
- 2006-05-04 ES ES08075300.7T patent/ES2577433T3/es active Active
- 2006-05-04 SG SG2014007512A patent/SG2014007512A/en unknown
- 2006-05-04 CN CN200680014981.9A patent/CN101171039B/zh not_active Expired - Fee Related
- 2006-05-04 NZ NZ561710A patent/NZ561710A/en not_active IP Right Cessation
- 2006-05-04 SI SI200631620T patent/SI1877098T1/sl unknown
- 2006-05-04 ES ES06727008T patent/ES2415244T3/es active Active
-
2007
- 2007-09-27 ZA ZA200708283A patent/ZA200708283B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
SI1877098T1 (sl) | 2013-08-30 |
NZ561710A (en) | 2010-08-27 |
PT1877098E (pt) | 2013-07-31 |
CA2836827A1 (fr) | 2006-11-09 |
ZA200708283B (en) | 2008-10-29 |
DK1877098T3 (da) | 2013-07-08 |
GB0509226D0 (en) | 2005-06-15 |
CN101171039B (zh) | 2013-01-23 |
ES2415244T3 (es) | 2013-07-24 |
SG2014007512A (en) | 2014-03-28 |
CN101171039A (zh) | 2008-04-30 |
ES2577433T3 (es) | 2016-07-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20131217 |