CA2836769C - The combination of paclitaxel and an mtor inhibitor for the treatment of a proliferative disorder - Google Patents
The combination of paclitaxel and an mtor inhibitor for the treatment of a proliferative disorder Download PDFInfo
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- CA2836769C CA2836769C CA2836769A CA2836769A CA2836769C CA 2836769 C CA2836769 C CA 2836769C CA 2836769 A CA2836769 A CA 2836769A CA 2836769 A CA2836769 A CA 2836769A CA 2836769 C CA2836769 C CA 2836769C
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- aryl
- another embodiment
- substituted
- heteroaryl
- heterocyclyl
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161482568P | 2011-05-04 | 2011-05-04 | |
| US61/482,568 | 2011-05-04 | ||
| PCT/US2012/036688 WO2012151562A1 (en) | 2011-05-04 | 2012-05-04 | Combination pharmaceutical compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2836769A1 CA2836769A1 (en) | 2012-11-08 |
| CA2836769C true CA2836769C (en) | 2018-11-13 |
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| CA2836769A Active CA2836769C (en) | 2011-05-04 | 2012-05-04 | The combination of paclitaxel and an mtor inhibitor for the treatment of a proliferative disorder |
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| EP (1) | EP2705181B1 (enExample) |
| JP (1) | JP6047149B2 (enExample) |
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| CA (1) | CA2836769C (enExample) |
| ES (1) | ES2618489T3 (enExample) |
| WO (1) | WO2012151562A1 (enExample) |
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| WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
| WO2010006072A2 (en) | 2008-07-08 | 2010-01-14 | The Regents Of The University Of California | Mtor modulators and uses thereof |
| JP6047149B2 (ja) | 2011-05-04 | 2016-12-21 | インテリカイン， エルエルシー | 併用の医薬組成物およびその使用 |
| JP6122420B2 (ja) * | 2011-05-06 | 2017-04-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 多発性嚢胞疾患の治療 |
| CN105209042B (zh) | 2013-03-22 | 2019-03-08 | 米伦纽姆医药公司 | 催化性mtorc 1/2抑制剂与选择性极光a激酶抑制剂的组合 |
| US20160367627A1 (en) | 2013-07-02 | 2016-12-22 | Nikolai Khodarev | Anti-tumor therapy |
| JP6725501B2 (ja) * | 2014-07-02 | 2020-07-22 | ザビエル・ユニバーシティ・オブ・ルイジアナＸａｖｉｅｒ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｌｏｕｉｓｉａｎａ | 少なくとも１つのフェノール（または芳香族ヒドロキシル）基を含有する薬物分子に関する増大された生物学的利用能及びより低い必要用量のためのホウ素系プロドラッグ戦略 |
| CA2960992C (en) * | 2014-09-11 | 2024-04-09 | The Regents Of The University Of California | Mtorc1 inhibitors |
| WO2016057931A1 (en) | 2014-10-10 | 2016-04-14 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| ES2749679T3 (es) | 2014-10-22 | 2020-03-23 | Bristol Myers Squibb Co | Compuestos de pirrolotriazina amina sustituidos como inhibidores de PI3k |
| ES2807785T3 (es) | 2014-10-22 | 2021-02-24 | Bristol Myers Squibb Co | Compuestos de heteroarilamina bicíclicos como inhibidores de pi3k |
| WO2016103190A1 (en) * | 2014-12-24 | 2016-06-30 | The University Of North Carolina At Chapel Hill | Combined local delivery of therapeutic agents using interventional devices and radiation |
| HUE064656T2 (hu) | 2016-03-28 | 2024-04-28 | Incyte Corp | Pirrolotriazin vegyületek mint TAM inhibitorok |
| PL3442535T3 (pl) | 2016-04-15 | 2022-10-24 | Cancer Research Technology Limited | Związki heterocykliczne jako inhibitory kinazy ret |
| RU2742115C2 (ru) | 2016-04-15 | 2021-02-02 | Кэнсер Рисерч Текнолоджи Лимитед | Гетероциклические соединения в качестве ингибиторов киназы RET |
| CA3039582A1 (en) * | 2016-10-07 | 2018-04-12 | Abraxis Bioscience, Llc | Methods of treating biliary tract cancer |
| GB201705971D0 (en) | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
| FR3075795A1 (fr) * | 2017-12-21 | 2019-06-28 | Galderma Research & Development | Nouveaux composes inhibiteurs de mtor |
| FR3075794A1 (fr) | 2017-12-21 | 2019-06-28 | Galderma Research & Development | Nouveaux composes inhibiteurs de mtor |
| RS64272B1 (sr) | 2018-05-01 | 2023-07-31 | Revolution Medicines Inc | C40-, c28- i c-32-vezani analozi rapamicina kao inhibitori mtor |
| EP3788050B1 (en) | 2018-05-01 | 2024-08-28 | Revolution Medicines, Inc. | C26-linked rapamycin analogs as mtor inhibitors |
| JP7668536B2 (ja) * | 2020-02-07 | 2025-04-25 | 範行 東 | 細胞周期のｇ１期初期制御剤 |
| US20230084515A1 (en) * | 2020-02-19 | 2023-03-16 | Vanderbilt University | Therapeutic methods and compositions for treating cancer using braf and/or mek inhibitor combination therapy |
| US12014835B2 (en) | 2020-02-19 | 2024-06-18 | Vanderbilt University | Methods for evaluating therapeutic benefit of combination therapies |
| CA3256390A1 (en) | 2022-05-25 | 2023-11-30 | Revolution Medicines, Inc. | CANCER TREATMENT METHODS USING AN MTOR INHIBITOR |
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| WO2001045676A2 (en) * | 1999-12-20 | 2001-06-28 | Schering Corporation | Extended release oral dosage composition |
| WO2009008992A2 (en) * | 2007-07-06 | 2009-01-15 | Osi Pharmaceuticals Inc. | Combination anti-cancer therapy comprising an inhibitor of both mtorc1 and mt0rc2 |
| WO2009114874A2 (en) * | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Benzothiazole kinase inhibitors and methods of use |
| EP2313414B1 (en) | 2008-07-08 | 2015-11-04 | Intellikine, LLC | Kinase inhibitors and methods of use |
| JP5731978B2 (ja) | 2008-09-26 | 2015-06-10 | インテリカイン， エルエルシー | 複素環キナーゼ阻害剤 |
| RU2538683C2 (ru) * | 2008-10-31 | 2015-01-10 | Новартис Аг | КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR |
| US8476431B2 (en) * | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
| JP6047149B2 (ja) | 2011-05-04 | 2016-12-21 | インテリカイン， エルエルシー | 併用の医薬組成物およびその使用 |
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| EP2705181A4 (en) | 2014-10-08 |
| US20160287595A1 (en) | 2016-10-06 |
| JP6047149B2 (ja) | 2016-12-21 |
| ES2618489T3 (es) | 2017-06-21 |
| CN103703174B (zh) | 2017-05-10 |
| EP2705181A1 (en) | 2014-03-12 |
| EP2705181B1 (en) | 2016-12-21 |
| CN103703174A (zh) | 2014-04-02 |
| US10172858B2 (en) | 2019-01-08 |
| CA2836769A1 (en) | 2012-11-08 |
| US20140357651A1 (en) | 2014-12-04 |
| WO2012151562A1 (en) | 2012-11-08 |
| HK1195793A1 (en) | 2014-11-21 |
| JP2014513138A (ja) | 2014-05-29 |
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